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Highlighted STAT3 as a potential drug target for cancer therapy.
Lee H, Jeong AJ, Ye SK. Lee H, et al. BMB Rep. 2019 Jul;52(7):415-423. doi: 10.5483/BMBRep.2019.52.7.152. BMB Rep. 2019. PMID: 31186087 Free PMC article. Review.
STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells.
Jung JE, Lee HG, Cho IH, Chung DH, Yoon SH, Yang YM, Lee JW, Choi S, Park JW, Ye SK, Chung MH. Jung JE, et al. FASEB J. 2005 Aug;19(10):1296-8. doi: 10.1096/fj.04-3099fje. Epub 2005 May 26. FASEB J. 2005. PMID: 15919761
Anti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: suppression of STAT3-mediated intercellular adhesion molecule-1 expression.
Kim DH, Cho IH, Kim HS, Jung JE, Kim JE, Lee KH, Park T, Yang YM, Seong SY, Ye SK, Chung MH. Kim DH, et al. Exp Mol Med. 2006 Aug 31;38(4):417-27. doi: 10.1038/emm.2006.49. Exp Mol Med. 2006. PMID: 16953121
Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells.
Jung JE, Kim HS, Lee CS, Park DH, Kim YN, Lee MJ, Lee JW, Park JW, Kim MS, Ye SK, Chung MH. Jung JE, et al. Carcinogenesis. 2007 Aug;28(8):1780-7. doi: 10.1093/carcin/bgm130. Epub 2007 Jun 8. Carcinogenesis. 2007. PMID: 17557905
STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination.
Jung JE, Kim HS, Lee CS, Shin YJ, Kim YN, Kang GH, Kim TY, Juhnn YS, Kim SJ, Park JW, Ye SK, Chung MH. Jung JE, et al. Exp Mol Med. 2008 Oct 31;40(5):479-85. doi: 10.3858/emm.2008.40.5.479. Exp Mol Med. 2008. PMID: 18985005 Free PMC article.
LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression.
Kim JE, Kim HS, Shin YJ, Lee CS, Won C, Lee SA, Lee JW, Kim Y, Kang JS, Ye SK, Chung MH. Kim JE, et al. Exp Mol Med. 2008 Oct 31;40(5):514-22. doi: 10.3858/emm.2008.40.5.514. Exp Mol Med. 2008. PMID: 18985009 Free PMC article.
Zeolite 4A, a synthetic silicate, suppresses melanogenesis through the degradation of microphthalmia-associated transcription factor by extracellular signal-regulated kinase activation in B16F10 melanoma cells.
Shin YJ, Han CS, Lee CS, Kim HS, Ko SH, Hwang SK, Ko SG, Shin JW, Ye SK, Chung MH. Shin YJ, et al. Biol Pharm Bull. 2010;33(1):72-6. doi: 10.1248/bpb.33.72. Biol Pharm Bull. 2010. PMID: 20045939
Hemin inhibits cyclin D1 and IGF-1 expression via STAT5b under hypoxia in ERalpha-negative MDA-MB 231 breast cancer cells.
Lim EJ, Joung YH, Jung SM, Park SH, Park JH, Kim SY, Hwang TS, Hong DY, Chung SC, Ye SK, Moon ES, Park EU, Park T, Chung IM, Yang YM. Lim EJ, et al. Int J Oncol. 2010 May;36(5):1243-51. doi: 10.3892/ijo_00000608. Int J Oncol. 2010. PMID: 20372799
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