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Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells.
Shimizu H, Yisireyili M, Higashiyama Y, Nishijima F, Niwa T. Shimizu H, et al. Among authors: yisireyili m. Life Sci. 2013 Feb 7;92(2):143-8. doi: 10.1016/j.lfs.2012.11.012. Epub 2012 Nov 28. Life Sci. 2013. PMID: 23201429
Stat3 contributes to indoxyl sulfate-induced inflammatory and fibrotic gene expression and cellular senescence.
Shimizu H, Yisireyili M, Nishijima F, Niwa T. Shimizu H, et al. Among authors: yisireyili m. Am J Nephrol. 2012;36(2):184-9. doi: 10.1159/000341515. Epub 2012 Aug 8. Am J Nephrol. 2012. PMID: 22889746
Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells.
Shimizu H, Yisireyili M, Nishijima F, Niwa T. Shimizu H, et al. Among authors: yisireyili m. Am J Nephrol. 2013;37(2):97-103. doi: 10.1159/000346420. Epub 2013 Jan 25. Am J Nephrol. 2013. PMID: 23363842
Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB.
Bolati D, Shimizu H, Yisireyili M, Nishijima F, Niwa T. Bolati D, et al. Among authors: yisireyili m. BMC Nephrol. 2013 Mar 4;14:56. doi: 10.1186/1471-2369-14-56. BMC Nephrol. 2013. PMID: 23496811 Free PMC article.
Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats.
Yisireyili M, Shimizu H, Saito S, Enomoto A, Nishijima F, Niwa T. Yisireyili M, et al. Life Sci. 2013 Jul 10;92(24-26):1180-5. doi: 10.1016/j.lfs.2013.05.008. Epub 2013 May 21. Life Sci. 2013. PMID: 23702423
Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of TGF-β1 and α-smooth muscle actin in proximal tubular cells.
Saito S, Shimizu H, Yisireyili M, Nishijima F, Enomoto A, Niwa T. Saito S, et al. Among authors: yisireyili m. Endocrinology. 2014 May;155(5):1899-907. doi: 10.1210/en.2013-1937. Epub 2014 Mar 6. Endocrinology. 2014. PMID: 24601883
Indoxyl sulfate downregulates expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells.
Ng HY, Yisireyili M, Saito S, Lee CT, Adelibieke Y, Nishijima F, Niwa T. Ng HY, et al. Among authors: yisireyili m. PLoS One. 2014 Mar 10;9(3):e91517. doi: 10.1371/journal.pone.0091517. eCollection 2014. PLoS One. 2014. PMID: 24614509 Free PMC article.
Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells.
Yisireyili M, Saito S, Abudureyimu S, Adelibieke Y, Ng HY, Nishijima F, Takeshita K, Murohara T, Niwa T. Yisireyili M, et al. PLoS One. 2014 Oct 24;9(10):e109268. doi: 10.1371/journal.pone.0109268. eCollection 2014. PLoS One. 2014. PMID: 25343458 Free PMC article.
Indoxyl sulfate induces IL-6 expression in vascular endothelial and smooth muscle cells through OAT3-mediated uptake and activation of AhR/NF-κB pathway.
Adelibieke Y, Yisireyili M, Ng HY, Saito S, Nishijima F, Niwa T. Adelibieke Y, et al. Among authors: yisireyili m. Nephron Exp Nephrol. 2014;128(1-2):1-8. doi: 10.1159/000365217. Epub 2014 Nov 5. Nephron Exp Nephrol. 2014. PMID: 25376195
Indoxyl sulfate upregulates prorenin expression via nuclear factor-κB p65, signal transducer and activator of transcription 3, and reactive oxygen species in proximal tubular cells.
Saito S, Yisireyili M, Shimizu H, Ng HY, Niwa T. Saito S, et al. Among authors: yisireyili m. J Ren Nutr. 2015 Mar;25(2):145-8. doi: 10.1053/j.jrn.2014.10.008. Epub 2014 Dec 31. J Ren Nutr. 2015. PMID: 25556305
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