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Year Number of Results
1998 1
2005 3
2006 1
2007 4
2008 14
2009 22
2010 21
2011 18
2012 20
2013 29
2014 22
2015 23
2016 16
2017 15
2018 18
2019 16
2020 14
2021 16
2022 15
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Yokukansan-induced reduction of ethanol preference is associated with antagonism of 5-HT3 receptors.
Nakamura Y, Kondo M, Koyama Y, Shimada S. Nakamura Y, et al. Phytomedicine. 2019 Jun;59:152897. doi: 10.1016/j.phymed.2019.152897. Epub 2019 Mar 20. Phytomedicine. 2019. PMID: 30974311
However, the effect of yokukansan on alcohol preference is not clear. PURPOSE: This study was performed to investigate the direct effect of yokukansan on alcohol preference and the effect of 5-HT(3) receptors on the preference. STUDY DESIGN: We examined ethanol pref …
However, the effect of yokukansan on alcohol preference is not clear. PURPOSE: This study was performed to investigate the direct eff …
Potential Application of Yokukansan as a Remedy for Parkinson's Disease.
Jang JH, Jung K, Kim JS, Jung I, Yoo H, Moon C. Jang JH, et al. Evid Based Complement Alternat Med. 2018 Dec 20;2018:1875928. doi: 10.1155/2018/1875928. eCollection 2018. Evid Based Complement Alternat Med. 2018. PMID: 30671124 Free PMC article. Review.
There have been efforts to develop complementary and alternative therapies for incurable PD. Yokukansan (YKS) is a traditional herbal medicine that is widely used for treating neurosis, insomnia, and night crying in children. ...
There have been efforts to develop complementary and alternative therapies for incurable PD. Yokukansan (YKS) is a traditional herbal …
Yokukansan in the treatment of behavioral and psychological symptoms of dementia: a systematic review and meta-analysis of randomized controlled trials.
Matsuda Y, Kishi T, Shibayama H, Iwata N. Matsuda Y, et al. Hum Psychopharmacol. 2013 Jan;28(1):80-6. doi: 10.1002/hup.2286. Hum Psychopharmacol. 2013. PMID: 23359469 Review.
Mini-mental state examination scores did not differ between the Yokukansan and UC treatment groups. Yokukansan was not different from UC regarding discontinuation due to any cause. CONCLUSION: Our results suggest that Yokukansan has a beneficial effect on NPI …
Mini-mental state examination scores did not differ between the Yokukansan and UC treatment groups. Yokukansan was not differe …
Yokukansan, a Japanese Herbal Medicine, Suppresses Substance PInduced Production of Interleukin-6 and Interleukin-8 by Human U373 MG Glioblastoma Astrocytoma Cells.
Yamaguchi K, Yamazaki S, Kumakura S, Someya A, Iseki M, Inada E, Nagaoka I. Yamaguchi K, et al. Endocr Metab Immune Disord Drug Targets. 2020;20(7):1073-1080. doi: 10.2174/1871530320666200131103733. Endocr Metab Immune Disord Drug Targets. 2020. PMID: 32003704
BACKGROUND: Yokukansan is a traditional Japanese herbal medicine that has an antiallodynic effect in patients with chronic pain. ...Yokukansan also inhibited phosphorylation of ERK1/2 and p38 MAPK, as well as nuclear translocation of NF-kappaB, induced by SP stimula …
BACKGROUND: Yokukansan is a traditional Japanese herbal medicine that has an antiallodynic effect in patients with chronic pain. ... …
Yokukansan enhances the proliferation of B65 neuroblastoma.
Nakatani Y, Amano T, Yamamoto H, Sakai N, Tsuji M, Takeda H. Nakatani Y, et al. J Tradit Complement Med. 2016 Feb 22;7(1):34-44. doi: 10.1016/j.jtcme.2016.01.006. eCollection 2017 Jan. J Tradit Complement Med. 2016. PMID: 28053886 Free PMC article.
Moreover, it has been shown that yokukansan has antidepressant-like and pain-relieving effects in animal models. ...We assessed the effect of yokukansan on p44/42 mitogen-activated protein kinase (MAPK) phosphorylation in B65 neuroblastoma cells, and found that y …
Moreover, it has been shown that yokukansan has antidepressant-like and pain-relieving effects in animal models. ...We assessed the e …
Yokukansan and its ingredients as possible treatment options for schizophrenia.
Yu CH, Ishii R, Yu SC, Takeda M. Yu CH, et al. Neuropsychiatr Dis Treat. 2014 Sep 1;10:1629-34. doi: 10.2147/NDT.S67607. eCollection 2014. Neuropsychiatr Dis Treat. 2014. PMID: 25210456 Free PMC article. Review.
As a result, searching for comparable treatment options with safer profiles is very important. Yokukansan (TJ-54), also called yi-gan san in Chinese, is a traditional herbal medicine with evident therapeutic effect for neuropsychiatric disorders. There …
As a result, searching for comparable treatment options with safer profiles is very important. Yokukansan (TJ-54), also called yi …
Kampo Formulae for the Treatment of Neuropathic Pain ∼ Especially the Mechanism of Action of Yokukansan ∼.
Sunagawa M, Takayama Y, Kato M, Tanaka M, Fukuoka S, Okumo T, Tsukada M, Yamaguchi K. Sunagawa M, et al. Front Mol Neurosci. 2021 Dec 14;14:705023. doi: 10.3389/fnmol.2021.705023. eCollection 2021. Front Mol Neurosci. 2021. PMID: 34970116 Free PMC article. Review.
This review outlines the Kampo formulae that are frequently used for pain treatment and their crude drugs and the basic usage of each component. In recent years, Yokukansan (YKS) has become one of the most used Kampo formulae for pain treatment with an increasing body of b …
This review outlines the Kampo formulae that are frequently used for pain treatment and their crude drugs and the basic usage of each compon …
Yokukansan for Treatment of Preoperative Anxiety and Prevention of Postoperative Delirium in Cancer Patients Undergoing Highly Invasive Surgery. J-SUPPORT 1605 (ProD Study): A Randomized, Double-Blind, Placebo-Controlled Trial.
Wada S, Sadahiro R, Matsuoka YJ, Uchitomi Y, Yamaguchi T, Sato T, Shimada K, Yoshimoto S, Daiko H, Kanemitsu Y, Kawai A, Kato T, Fujimoto H, Shimizu K. Wada S, et al. J Pain Symptom Manage. 2021 Jan;61(1):71-80. doi: 10.1016/j.jpainsymman.2020.07.009. Epub 2020 Aug 12. J Pain Symptom Manage. 2021. PMID: 32800969 Clinical Trial.
CONCLUSION: In patients with cancer undergoing highly invasive surgeries, yokukansan demonstrated no significant efficacy for the treatment of preoperative anxiety or the prevention of postoperative delirium. Yokukansan is already used in daily practice in Japan, bu …
CONCLUSION: In patients with cancer undergoing highly invasive surgeries, yokukansan demonstrated no significant efficacy for the tre …
Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis.
Stinton C, McKeith I, Taylor JP, Lafortune L, Mioshi E, Mak E, Cambridge V, Mason J, Thomas A, O'Brien JT. Stinton C, et al. Am J Psychiatry. 2015 Aug 1;172(8):731-42. doi: 10.1176/appi.ajp.2015.14121582. Epub 2015 Jun 18. Am J Psychiatry. 2015. PMID: 26085043 Free article. Review.
Descriptive summaries provide some evidence of benefits for galantamine, modafinil, levodopa, rotigotine, clozapine, duloxetine, clonazepam, ramelteon, gabapentin, zonisamide, and yokukansan. Piracetam, amantadine, selegiline, olanzapine, quetiapine, risperidone, and cital …
Descriptive summaries provide some evidence of benefits for galantamine, modafinil, levodopa, rotigotine, clozapine, duloxetine, clonazepam, …
Yokukansan Reduces Cuprizone-Induced Demyelination in the Corpus Callosum Through Anti-inflammatory Effects on Microglia.
Nomura T, Bando Y, You H, Tanaka T, Yoshida S. Nomura T, et al. Neurochem Res. 2017 Dec;42(12):3525-3536. doi: 10.1007/s11064-017-2400-z. Epub 2017 Sep 19. Neurochem Res. 2017. PMID: 28929408
However, whether or not yokukansan reduces demyelination observed in the CNS during MS remains unknown. ...As yokukansan has few adverse effects, yokukansan has the potential to be a novel option to treat MS....
However, whether or not yokukansan reduces demyelination observed in the CNS during MS remains unknown. ...As yokukansan has f …
250 results