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Yokukansan-induced reduction of ethanol preference is associated with antagonism of 5-HT3 receptors.
Nakamura Y, Kondo M, Koyama Y, Shimada S. Nakamura Y, et al. Phytomedicine. 2019 Jun;59:152897. doi: 10.1016/j.phymed.2019.152897. Epub 2019 Mar 20. Phytomedicine. 2019. PMID: 30974311
However, the effect of yokukansan on alcohol preference is not clear. PURPOSE: This study was performed to investigate the direct effect of yokukansan on alcohol preference and the effect of 5-HT(3) receptors on the preference. STUDY DESIGN: We examined ethanol pref …
However, the effect of yokukansan on alcohol preference is not clear. PURPOSE: This study was performed to investigate the direct eff …
Potential Application of Yokukansan as a Remedy for Parkinson's Disease.
Jang JH, Jung K, Kim JS, Jung I, Yoo H, Moon C. Jang JH, et al. Evid Based Complement Alternat Med. 2018 Dec 20;2018:1875928. doi: 10.1155/2018/1875928. eCollection 2018. Evid Based Complement Alternat Med. 2018. PMID: 30671124 Free PMC article. Review.
There have been efforts to develop complementary and alternative therapies for incurable PD. Yokukansan (YKS) is a traditional herbal medicine that is widely used for treating neurosis, insomnia, and night crying in children. ...
There have been efforts to develop complementary and alternative therapies for incurable PD. Yokukansan (YKS) is a traditional herbal …
Yokukansan in the treatment of behavioral and psychological symptoms of dementia: a systematic review and meta-analysis of randomized controlled trials.
Matsuda Y, Kishi T, Shibayama H, Iwata N. Matsuda Y, et al. Hum Psychopharmacol. 2013 Jan;28(1):80-6. doi: 10.1002/hup.2286. Hum Psychopharmacol. 2013. PMID: 23359469 Review.
Mini-mental state examination scores did not differ between the Yokukansan and UC treatment groups. Yokukansan was not different from UC regarding discontinuation due to any cause. CONCLUSION: Our results suggest that Yokukansan has a beneficial effect on NPI …
Mini-mental state examination scores did not differ between the Yokukansan and UC treatment groups. Yokukansan was not differe …
Yokukansan, a Japanese Herbal Medicine, Suppresses Substance PInduced Production of Interleukin-6 and Interleukin-8 by Human U373 MG Glioblastoma Astrocytoma Cells.
Yamaguchi K, Yamazaki S, Kumakura S, Someya A, Iseki M, Inada E, Nagaoka I. Yamaguchi K, et al. Endocr Metab Immune Disord Drug Targets. 2020;20(7):1073-1080. doi: 10.2174/1871530320666200131103733. Endocr Metab Immune Disord Drug Targets. 2020. PMID: 32003704
BACKGROUND: Yokukansan is a traditional Japanese herbal medicine that has an antiallodynic effect in patients with chronic pain. ...Yokukansan also inhibited phosphorylation of ERK1/2 and p38 MAPK, as well as nuclear translocation of NF-kappaB, induced by SP stimula …
BACKGROUND: Yokukansan is a traditional Japanese herbal medicine that has an antiallodynic effect in patients with chronic pain. ... …
Effect of Yokukansan on Nitric Oxide Production and Hydroxyl Radical Metabolism During Cerebral Ischemia and Reperfusion in Mice.
Kitabayashi C, Ito Y, Kawasaki H, Tanaka A, Nishioka R, Yamazato M, Ishizawa K, Nagai T, Hirayama M, Takahashi K, Yamamoto T, Araki N. Kitabayashi C, et al. J Stroke Cerebrovasc Dis. 2019 May;28(5):1151-1159. doi: 10.1016/j.jstrokecerebrovasdis.2018.12.047. Epub 2019 Jan 14. J Stroke Cerebrovasc Dis. 2019. PMID: 30655039
BACKGROUND: The purpose of this study was to investigate the effects of yokukansan on forebrain ischemia. Because we can measure nitric oxide production and hydroxyl radical metabolism continuously, we investigated the effect of yokukansan on nitric oxide production …
BACKGROUND: The purpose of this study was to investigate the effects of yokukansan on forebrain ischemia. Because we can measure nitr …
Yokukansan Reduces Cuprizone-Induced Demyelination in the Corpus Callosum Through Anti-inflammatory Effects on Microglia.
Nomura T, Bando Y, You H, Tanaka T, Yoshida S. Nomura T, et al. Neurochem Res. 2017 Dec;42(12):3525-3536. doi: 10.1007/s11064-017-2400-z. Epub 2017 Sep 19. Neurochem Res. 2017. PMID: 28929408
However, whether or not yokukansan reduces demyelination observed in the CNS during MS remains unknown. ...As yokukansan has few adverse effects, yokukansan has the potential to be a novel option to treat MS....
However, whether or not yokukansan reduces demyelination observed in the CNS during MS remains unknown. ...As yokukansan has f …
Yokukansan and its ingredients as possible treatment options for schizophrenia.
Yu CH, Ishii R, Yu SC, Takeda M. Yu CH, et al. Neuropsychiatr Dis Treat. 2014 Sep 1;10:1629-34. doi: 10.2147/NDT.S67607. eCollection 2014. Neuropsychiatr Dis Treat. 2014. PMID: 25210456 Free PMC article. Review.
As a result, searching for comparable treatment options with safer profiles is very important. Yokukansan (TJ-54), also called yi-gan san in Chinese, is a traditional herbal medicine with evident therapeutic effect for neuropsychiatric disorders. There …
As a result, searching for comparable treatment options with safer profiles is very important. Yokukansan (TJ-54), also called yi …
Yokukansan enhances the proliferation of B65 neuroblastoma.
Nakatani Y, Amano T, Yamamoto H, Sakai N, Tsuji M, Takeda H. Nakatani Y, et al. J Tradit Complement Med. 2016 Feb 22;7(1):34-44. doi: 10.1016/j.jtcme.2016.01.006. eCollection 2017 Jan. J Tradit Complement Med. 2016. PMID: 28053886 Free PMC article.
Moreover, it has been shown that yokukansan has antidepressant-like and pain-relieving effects in animal models. ...We assessed the effect of yokukansan on p44/42 mitogen-activated protein kinase (MAPK) phosphorylation in B65 neuroblastoma cells, and found that y …
Moreover, it has been shown that yokukansan has antidepressant-like and pain-relieving effects in animal models. ...We assessed the e …
Yokukansan, a traditional Japanese herbal medicine, enhances the anxiolytic effect of fluvoxamine and reduces cortical 5-HT(2A) receptor expression in mice.
Ohno R, Miyagishi H, Tsuji M, Saito A, Miyagawa K, Kurokawa K, Takeda H. Ohno R, et al. J Ethnopharmacol. 2018 Apr 24;216:89-96. doi: 10.1016/j.jep.2018.01.032. Epub 2018 Jan 31. J Ethnopharmacol. 2018. PMID: 29382554
ETHNOPHARMACOLOGICAL RELEVANCE: Yokukansan is a traditional Japanese herbal medicine that has been approved in Japan as a remedy for neurosis, insomnia, and irritability in children. ...Therefore, combination therapy with fluvoxamine and yokukansan may be beneficial …
ETHNOPHARMACOLOGICAL RELEVANCE: Yokukansan is a traditional Japanese herbal medicine that has been approved in Japan as a remedy for …
Risk Factors for Pseudoaldosteronism with Yokukansan Use: Analysis Using the Japanese Adverse Drug Report (JADER) Database.
Ishida T, Kawada K, Morisawa S, Jobu K, Morita Y, Miyamura M. Ishida T, et al. Biol Pharm Bull. 2020;43(10):1570-1576. doi: 10.1248/bpb.b20-00424. Biol Pharm Bull. 2020. PMID: 32999167 Free article.
Yokukansan is a Kampo formula that is commonly used by the elderly because it is expected to improve peripheral symptoms of dementia and delirium. ...We also analyzed the risk factors for pseudoaldosteronism in patients taking yokukansan. Yokukansan (ROR 2.4, …
Yokukansan is a Kampo formula that is commonly used by the elderly because it is expected to improve peripheral symptoms of dementia …
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