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DT56a stimulates gender-specific human cultured bone cells in vitro.
Somjen D, Katzburg S, Lieberherr M, Hendel D, Yoles I. Somjen D, et al. Among authors: yoles i. J Steroid Biochem Mol Biol. 2006 Jan;98(1):90-6. doi: 10.1016/j.jsbmb.2005.08.002. Epub 2005 Oct 21. J Steroid Biochem Mol Biol. 2006. PMID: 16243521
The selective estrogen receptor modulator DT56a (Femarelle) does not affect platelet reactivity in normal or thrombophilic postmenopausal women.
Nachtigall MJ, Jessel RH, Flaumenhaft R, Nachtigall R, Yoles I, Naftolin F, Nachtigall LE. Nachtigall MJ, et al. Among authors: yoles i. Menopause. 2011 Mar;18(3):285-8. doi: 10.1097/gme.0b013e3181f2f01a. Menopause. 2011. PMID: 21037489
DT56a (Femarelle): a natural selective estrogen receptor modulator (SERM).
Somjen D, Katzburg S, Knoll E, Hendel D, Stern N, Kaye AM, Yoles I. Somjen D, et al. Among authors: yoles i. J Steroid Biochem Mol Biol. 2007 May;104(3-5):252-8. doi: 10.1016/j.jsbmb.2007.03.004. Epub 2007 Mar 14. J Steroid Biochem Mol Biol. 2007. PMID: 17428655
DT56a (Femarelle) stimulates bone formation in female rats.
Somjen D, Katzburg S, Livne E, Yoles I. Somjen D, et al. Among authors: yoles i. BJOG. 2005 Jul;112(7):981-5. doi: 10.1111/j.1471-0528.2005.00573.x. BJOG. 2005. PMID: 15958004
DT56a (Tofupill/Femarelle) selectively stimulates creatine kinase specific activity in skeletal tissues of rats but not in the uterus.
Somjen D, Yoles I. Somjen D, et al. Among authors: yoles i. J Steroid Biochem Mol Biol. 2003 Jul;86(1):93-8. doi: 10.1016/s0960-0760(03)00252-8. J Steroid Biochem Mol Biol. 2003. PMID: 12943748
Tofupill/Femarelle (DT56a): a new phyto-selective estrogen receptor modulator-like substance for the treatment of postmenopausal bone loss.
Yoles I, Yogev Y, Frenkel Y, Nahum R, Hirsch M, Kaplan B. Yoles I, et al. Menopause. 2003 Nov-Dec;10(6):522-5. doi: 10.1097/01.GME.0000064864.58809.77. Menopause. 2003. PMID: 14627860 Clinical Trial.
DT56a stimulates creatine kinase specific activity in vascular tissues of rats.
Somjen D, Yoles I. Somjen D, et al. Among authors: yoles i. J Endocrinol Invest. 2003 Oct;26(10):966-71. doi: 10.1007/BF03348193. J Endocrinol Invest. 2003. PMID: 14759068
Efficacy and safety of standard versus low-dose Femarelle (DT56a) for the treatment of menopausal symptoms.
Yoles I, Yogev Y, Frenkel Y, Hirsch M, Nahum R, Kaplan B. Yoles I, et al. Clin Exp Obstet Gynecol. 2004;31(2):123-6. Clin Exp Obstet Gynecol. 2004. PMID: 15266766 Clinical Trial.
The effects of native and synthetic estrogenic compounds as well as vitamin D less-calcemic analogs on adipocytes content in rat bone marrow.
Somjen D, Katzburg S, Kohen F, Gayer B, Posner GH, Yoles I, Livne E. Somjen D, et al. Among authors: yoles i. J Endocrinol Invest. 2011 Feb;34(2):106-10. doi: 10.1007/BF03347039. Epub 2010 Jun 11. J Endocrinol Invest. 2011. PMID: 20543554
DT56a (Femarelle), contrary to estradiol-17β, is effective in human derived female osteoblasts in hyperglycemic condition.
Somjen D, Katzburg S, Sharon O, Hendel D, Yoles I. Somjen D, et al. Among authors: yoles i. J Steroid Biochem Mol Biol. 2011 Jan;123(1-2):25-9. doi: 10.1016/j.jsbmb.2010.10.001. Epub 2010 Oct 14. J Steroid Biochem Mol Biol. 2011. PMID: 20951203
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