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Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.
Liby KT, Yore MM, Sporn MB. Liby KT, et al. Among authors: yore mm. Nat Rev Cancer. 2007 May;7(5):357-69. doi: 10.1038/nrc2129. Epub 2007 Apr 19. Nat Rev Cancer. 2007. PMID: 17446857 Review.
The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice.
Liby K, Royce DB, Williams CR, Risingsong R, Yore MM, Honda T, Gribble GW, Dmitrovsky E, Sporn TA, Sporn MB. Liby K, et al. Among authors: yore mm. Cancer Res. 2007 Mar 15;67(6):2414-9. doi: 10.1158/0008-5472.CAN-06-4534. Cancer Res. 2007. PMID: 17363558
The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.
Liby K, Hock T, Yore MM, Suh N, Place AE, Risingsong R, Williams CR, Royce DB, Honda T, Honda Y, Gribble GW, Hill-Kapturczak N, Agarwal A, Sporn MB. Liby K, et al. Among authors: yore mm. Cancer Res. 2005 Jun 1;65(11):4789-98. doi: 10.1158/0008-5472.CAN-04-4539. Cancer Res. 2005. PMID: 15930299
Limiting effects of RIP140 in estrogen signaling: potential mediation of anti-estrogenic effects of retinoic acid.
White KA, Yore MM, Deng D, Spinella MJ. White KA, et al. Among authors: yore mm. J Biol Chem. 2005 Mar 4;280(9):7829-35. doi: 10.1074/jbc.M412707200. Epub 2005 Jan 4. J Biol Chem. 2005. PMID: 15632153
New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress.
Sporn MB, Liby KT, Yore MM, Fu L, Lopchuk JM, Gribble GW. Sporn MB, et al. Among authors: yore mm. J Nat Prod. 2011 Mar 25;74(3):537-45. doi: 10.1021/np100826q. Epub 2011 Feb 10. J Nat Prod. 2011. PMID: 21309592 Free PMC article. Review.
Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR.
Yore MM, Kettenbach AN, Sporn MB, Gerber SA, Liby KT. Yore MM, et al. PLoS One. 2011;6(7):e22862. doi: 10.1371/journal.pone.0022862. Epub 2011 Jul 27. PLoS One. 2011. PMID: 21818401 Free PMC article.
Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice.
Liby K, Risingsong R, Royce DB, Williams CR, Ma T, Yore MM, Sporn MB. Liby K, et al. Among authors: yore mm. Cancer Prev Res (Phila). 2009 Dec;2(12):1050-8. doi: 10.1158/1940-6207.CAPR-09-0085. Epub 2009 Dec 1. Cancer Prev Res (Phila). 2009. PMID: 19952361 Free PMC article.
A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin.
Liby K, Yore MM, Roebuck BD, Baumgartner KJ, Honda T, Sundararajan C, Yoshizawa H, Gribble GW, Williams CR, Risingsong R, Royce DB, Dinkova-Kostova AT, Stephenson KK, Egner PA, Yates MS, Groopman JD, Kensler TW, Sporn MB. Liby K, et al. Among authors: yore mm. Cancer Res. 2008 Aug 15;68(16):6727-33. doi: 10.1158/0008-5472.CAN-08-1123. Cancer Res. 2008. PMID: 18701497 Free PMC article.
Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.
Liby K, Risingsong R, Royce DB, Williams CR, Yore MM, Honda T, Gribble GW, Lamph WW, Vannini N, Sogno I, Albini A, Sporn MB. Liby K, et al. Among authors: yore mm. Clin Cancer Res. 2008 Jul 15;14(14):4556-63. doi: 10.1158/1078-0432.CCR-08-0040. Clin Cancer Res. 2008. PMID: 18628471 Free PMC article.
For treatment, mice with established tumors at least 4 mm in diameter were fed control diet, CDDO-Me (100 mg/kg diet), 268 (60 mg/kg diet), or the combination for 4 weeks. ...
For treatment, mice with established tumors at least 4 mm in diameter were fed control diet, CDDO-Me (100 mg/kg diet), 268 (60 mg/kg …
The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis.
Liby K, Black CC, Royce DB, Williams CR, Risingsong R, Yore MM, Liu X, Honda T, Gribble GW, Lamph WW, Sporn TA, Dmitrovsky E, Sporn MB. Liby K, et al. Among authors: yore mm. Mol Cancer Ther. 2008 May;7(5):1251-7. doi: 10.1158/1535-7163.MCT-08-0023. Mol Cancer Ther. 2008. PMID: 18483313 Free PMC article.
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