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Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development.
Kanatani N, Fujita T, Fukuyama R, Liu W, Yoshida CA, Moriishi T, Yamana K, Miyazaki T, Toyosawa S, Komori T. Kanatani N, et al. Dev Biol. 2006 Aug 1;296(1):48-61. doi: 10.1016/j.ydbio.2006.03.039. Epub 2006 Apr 4. Dev Biol. 2006. PMID: 16797526
Akt regulates skeletal development through GSK3, mTOR, and FoxOs.
Rokutanda S, Fujita T, Kanatani N, Yoshida CA, Komori H, Liu W, Mizuno A, Komori T. Rokutanda S, et al. Dev Biol. 2009 Apr 1;328(1):78-93. doi: 10.1016/j.ydbio.2009.01.009. Epub 2009 Jan 14. Dev Biol. 2009. PMID: 19389373
Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells.
Tanaka T, Sato H, Doi H, Yoshida CA, Shimizu T, Matsui H, Yamazaki M, Akiyama H, Kawai-Kowase K, Iso T, Komori T, Arai M, Kurabayashi M. Tanaka T, et al. Mol Cell Biol. 2008 Feb;28(3):1147-60. doi: 10.1128/MCB.01771-07. Epub 2007 Nov 26. Mol Cell Biol. 2008. PMID: 18039851 Free PMC article.
Role of Runx proteins in chondrogenesis.
Yoshida CA, Komori T. Yoshida CA, et al. Crit Rev Eukaryot Gene Expr. 2005;15(3):243-54. doi: 10.1615/critreveukargeneexpr.v15.i3.60. Crit Rev Eukaryot Gene Expr. 2005. PMID: 16390320 Review.
Galnt3 deficiency disrupts acrosome formation and leads to oligoasthenoteratozoospermia.
Miyazaki T, Mori M, Yoshida CA, Ito C, Yamatoya K, Moriishi T, Kawai Y, Komori H, Kawane T, Izumi S, Toshimori K, Komori T. Miyazaki T, et al. Histochem Cell Biol. 2013 Feb;139(2):339-54. doi: 10.1007/s00418-012-1031-3. Epub 2012 Sep 28. Histochem Cell Biol. 2013. PMID: 23052838
Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling.
Fujita T, Azuma Y, Fukuyama R, Hattori Y, Yoshida C, Koida M, Ogita K, Komori T. Fujita T, et al. J Cell Biol. 2004 Jul 5;166(1):85-95. doi: 10.1083/jcb.200401138. Epub 2004 Jun 28. J Cell Biol. 2004. PMID: 15226309 Free PMC article.
Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes.
Ueta C, Iwamoto M, Kanatani N, Yoshida C, Liu Y, Enomoto-Iwamoto M, Ohmori T, Enomoto H, Nakata K, Takada K, Kurisu K, Komori T. Ueta C, et al. J Cell Biol. 2001 Apr 2;153(1):87-100. doi: 10.1083/jcb.153.1.87. J Cell Biol. 2001. PMID: 11285276 Free PMC article.
Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3.
Kawane T, Qin X, Jiang Q, Miyazaki T, Komori H, Yoshida CA, Matsuura-Kawata VKDS, Sakane C, Matsuo Y, Nagai K, Maeno T, Date Y, Nishimura R, Komori T. Kawane T, et al. Sci Rep. 2018 Sep 10;8(1):13551. doi: 10.1038/s41598-018-31853-0. Sci Rep. 2018. PMID: 30202094 Free PMC article.
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