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Obesity and cancer: a gut microbial connection.
Ohtani N, Yoshimoto S, Hara E. Ohtani N, et al. Among authors: yoshimoto s. Cancer Res. 2014 Apr 1;74(7):1885-9. doi: 10.1158/0008-5472.CAN-13-3501. Epub 2014 Mar 17. Cancer Res. 2014. PMID: 24638983 Review.
Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.
Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N. Loo TM, et al. Among authors: yoshimoto s. Cancer Discov. 2017 May;7(5):522-538. doi: 10.1158/2159-8290.CD-16-0932. Epub 2017 Feb 15. Cancer Discov. 2017. PMID: 28202625
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.
Takahashi A, Okada R, Nagao K, Kawamata Y, Hanyu A, Yoshimoto S, Takasugi M, Watanabe S, Kanemaki MT, Obuse C, Hara E. Takahashi A, et al. Among authors: yoshimoto s. Nat Commun. 2017 May 16;8:15287. doi: 10.1038/ncomms15287. Nat Commun. 2017. PMID: 28508895 Free PMC article.
Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion.
Okumura S, Konishi Y, Narukawa M, Sugiura Y, Yoshimoto S, Arai Y, Sato S, Yoshida Y, Tsuji S, Uemura K, Wakita M, Matsudaira T, Matsumoto T, Kawamoto S, Takahashi A, Itatani Y, Miki H, Takamatsu M, Obama K, Takeuchi K, Suematsu M, Ohtani N, Fukunaga Y, Ueno M, Sakai Y, Nagayama S, Hara E. Okumura S, et al. Among authors: yoshimoto s. Nat Commun. 2021 Sep 28;12(1):5674. doi: 10.1038/s41467-021-25965-x. Nat Commun. 2021. PMID: 34584098 Free PMC article.
Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma.
Yamagishi R, Kamachi F, Nakamura M, Yamazaki S, Kamiya T, Takasugi M, Cheng Y, Nonaka Y, Yukawa-Muto Y, Thuy LTT, Harada Y, Arai T, Loo TM, Yoshimoto S, Ando T, Nakajima M, Taguchi H, Ishikawa T, Akiba H, Miyake S, Kubo M, Iwakura Y, Fukuda S, Chen WY, Kawada N, Rudensky A, Nakae S, Hara E, Ohtani N. Yamagishi R, et al. Among authors: yoshimoto s. Sci Immunol. 2022 Jun 24;7(72):eabl7209. doi: 10.1126/sciimmunol.abl7209. Epub 2022 Jun 24. Sci Immunol. 2022. PMID: 35749514
697 results