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Page 1
The X-Age Project to construct a Chinese aging clock.
Li J, Jiang M, Wang Q, Zheng Z, Shen J, Li J, Xiong M, Zheng Y, Lu X, Cai Y, Fan Y, Geng L, Ji Q, Peng Q, Sun S, Wang Y, Xin Z, Yan K, Yang Y, Yu J, Yan H, Ai D, Bai Y, Bi Y, Bian XW, Bu P, Cai JP, Cao CM, Cao F, Cao Z, Chai R, Chan P, Chen C, Chen CS, Chen C, Chen D, Chen HZ, Chen L, Chen Q, Chen X, Chen X, Chen Y, Chen ZJ, Ci W, Dai Z, Ding Q, Dong B, Dong J, Fan JG, Feng S, Feng X, Feng Y, Fu X, Fu X, Gao F, Gao J, Gao Q, Gao S, Gu Y, Guan Y, Guo F, Han JJ, Hao H, Hao J, He F, He J, He M, He M, He Q, He Z, He Z, Hong H, Hong J, Hou S, Hu C, Hu P, Hu Z, Huang C, Huang J, Huang K, Huang P, Ji X, Ji Y, Jia S, Jiang H, Jiang W, Jin L, Jin ZB, Ju S, Ju Z, Kong QP, Kong W, Kong WJ, Kong X, Lei G, Li GL, Li J, Li J, Li M, Li R, Li W, Li W, Li XJ, Li X, Liang Q, Liang Z, Lin H, Liu B, Liu CY, Liu C, Liu F, Liu J, Liu JP, Liu K, Liu L, Liu P, Liu Q, Liu Q, Liu T, Liu W, Liu X, Liu Y, Liu Y, Liu Y, Liu Y, Liu Z, Long X, Lu Y, Luo J, Luo X, Ma C, Ma S, Ma X, Mao J, Mao Z, Ng SC, Nie G, Niu Y, Peng Y, Pu J, Qi J, Qiang L, Qiao J, Qin Y, Qu A, Qu J, Ren J, Ren R, Ruan XZ, Shi A, Shi H, Shi J, So KF, Song M, Song W, Songyang Z, Su J, Sun A, Sun L, Sun Q, Sun YE, S… See abstract for full author list ➔ Li J, et al. Among authors: liu y. Nat Aging. 2025 Sep;5(9):1669-1685. doi: 10.1038/s43587-025-00935-w. Epub 2025 Sep 9. Nat Aging. 2025. PMID: 40926127 Review.
To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks tha …
To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging eva …
The extracellular matrix glycoprotein fibrillin-1 in health and disease.
Li L, Huang J, Liu Y. Li L, et al. Among authors: liu y. Front Cell Dev Biol. 2024 Jan 10;11:1302285. doi: 10.3389/fcell.2023.1302285. eCollection 2023. Front Cell Dev Biol. 2024. PMID: 38269088 Free PMC article. Review.
As such, mutations in the FBN1 gene can cause a wide variety of genetic diseases such as Marfan syndrome, an autosomal dominant disorder characterized by ocular, skeletal and cardiovascular abnormalities. FBN1 also interacts with numerous microfibril-associated proteins, g …
As such, mutations in the FBN1 gene can cause a wide variety of genetic diseases such as Marfan syndrome, an autosomal dominant disorder cha …
Multiple genes of the renin-angiotensin system are novel targets of Wnt/beta-catenin signaling.
Zhou L, Li Y, Hao S, Zhou D, Tan RJ, Nie J, Hou FF, Kahn M, Liu Y. Zhou L, et al. Among authors: liu y. J Am Soc Nephrol. 2015 Jan;26(1):107-20. doi: 10.1681/ASN.2014010085. Epub 2014 Jul 10. J Am Soc Nephrol. 2015. PMID: 25012166 Free PMC article.
Activation of the renin-angiotensin system (RAS) plays an essential role in the pathogenesis of CKD and cardiovascular disease. ...
Activation of the renin-angiotensin system (RAS) plays an essential role in the pathogenesis of CKD and cardiovascular disease …
Loss of Klotho in CKD Breaks One's Heart.
Fu H, Liu Y. Fu H, et al. Among authors: liu y. J Am Soc Nephrol. 2015 Oct;26(10):2305-7. doi: 10.1681/ASN.2015020200. Epub 2015 Mar 24. J Am Soc Nephrol. 2015. PMID: 25804282 Free PMC article. No abstract available.
Wnt/β-catenin regulates blood pressure and kidney injury in rats.
Xiao L, Xu B, Zhou L, Tan RJ, Zhou D, Fu H, Li A, Hou FF, Liu Y. Xiao L, et al. Among authors: liu y. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1313-1322. doi: 10.1016/j.bbadis.2019.01.027. Epub 2019 Jan 30. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30710617 Free PMC article.
Activation of the renin-angiotensin system (RAS) plays a pivotal role in mediating hypertension, chronic kidney and cardiovascular diseases. ...
Activation of the renin-angiotensin system (RAS) plays a pivotal role in mediating hypertension, chronic kidney and cardiovascular …
Matrix metalloproteinases in kidney homeostasis and diseases.
Tan RJ, Liu Y. Tan RJ, et al. Among authors: liu y. Am J Physiol Renal Physiol. 2012 Jun 1;302(11):F1351-61. doi: 10.1152/ajprenal.00037.2012. Epub 2012 Apr 4. Am J Physiol Renal Physiol. 2012. PMID: 22492945 Free PMC article. Review.
An essential role for Wnt/β-catenin signaling in mediating hypertensive heart disease.
Zhao Y, Wang C, Wang C, Hong X, Miao J, Liao Y, Zhou L, Liu Y. Zhao Y, et al. Among authors: liu y. Sci Rep. 2018 Jun 12;8(1):8996. doi: 10.1038/s41598-018-27064-2. Sci Rep. 2018. PMID: 29895976 Free PMC article.
Activation of the renin-angiotensin system (RAS) is associated with hypertension and heart disease. However, how RAS activation causes cardiac lesions remains elusive. ...
Activation of the renin-angiotensin system (RAS) is associated with hypertension and heart disease. However, how RAS activation cause …
Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome.
Zhao Y, Wang C, Hong X, Miao J, Liao Y, Hou FF, Zhou L, Liu Y. Zhao Y, et al. Among authors: liu y. Kidney Int. 2019 Apr;95(4):815-829. doi: 10.1016/j.kint.2018.11.021. Epub 2019 Feb 12. Kidney Int. 2019. PMID: 30770217 Free PMC article.
The cardiac lesions were accompanied by upregulation of multiple Wnt ligands and activation of beta-catenin, as well as activation of the renin-angiotensin system (RAS). Wnt3a induced multiple components of the RAS in primary cardiomyocytes and cardiac fibroblasts in vitro …
The cardiac lesions were accompanied by upregulation of multiple Wnt ligands and activation of beta-catenin, as well as activation of the re …
Sympathetic Overactivity in CKD Disrupts Buffering of Neurotransmission by Endothelium-Derived Hyperpolarizing Factor and Enhances Vasoconstriction.
Cao W, Wu L, Zhang X, Zhou J, Wang J, Yang Z, Su H, Liu Y, Wilcox CS, Hou FF. Cao W, et al. Among authors: liu y. J Am Soc Nephrol. 2020 Oct;31(10):2312-2325. doi: 10.1681/ASN.2020030234. Epub 2020 Jul 2. J Am Soc Nephrol. 2020. PMID: 32616538 Free PMC article.
Vascular smooth muscle cells (VSMCs) of resistance arteries receive signals from the sympathetic nervous system that induce an endothelial cell (EC)-dependent anticontractile response that moderates vasoconstriction. ...
Vascular smooth muscle cells (VSMCs) of resistance arteries receive signals from the sympathetic nervous system that induce an endoth …
15 results