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Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes.
Nielsen LL, Young AA, Parkes DG. Nielsen LL, et al. Among authors: young aa. Regul Pept. 2004 Feb 15;117(2):77-88. doi: 10.1016/j.regpep.2003.10.028. Regul Pept. 2004. PMID: 14700743 Review.
Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187.
Gedulin BR, Jodka CM, Herrmann K, Young AA. Gedulin BR, et al. Among authors: young aa. Regul Pept. 2006 Dec 10;137(3):121-7. doi: 10.1016/j.regpep.2006.06.004. Epub 2006 Aug 17. Regul Pept. 2006. PMID: 16914214
Dose-response for inhibition by amylin of cholecystokinin-stimulated secretion of amylase and lipase in rats.
Young AA, Jodka C, Pittner R, Parkes D, Gedulin BR. Young AA, et al. Regul Pept. 2005 Aug 15;130(1-2):19-26. doi: 10.1016/j.regpep.2005.02.010. Regul Pept. 2005. PMID: 15982756
Exenatide (exendin-4) improves insulin sensitivity and {beta}-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight.
Gedulin BR, Nikoulina SE, Smith PA, Gedulin G, Nielsen LL, Baron AD, Parkes DG, Young AA. Gedulin BR, et al. Among authors: young aa. Endocrinology. 2005 Apr;146(4):2069-76. doi: 10.1210/en.2004-1349. Epub 2004 Dec 23. Endocrinology. 2005. PMID: 15618356
Pharmacokinetics and pharmacodynamics of exenatide following alternate routes of administration.
Gedulin BR, Smith PA, Jodka CM, Chen K, Bhavsar S, Nielsen LL, Parkes DG, Young AA. Gedulin BR, et al. Among authors: young aa. Int J Pharm. 2008 May 22;356(1-2):231-8. doi: 10.1016/j.ijpharm.2008.01.015. Epub 2008 Jan 17. Int J Pharm. 2008. PMID: 18291606
Obesity: a peptide YY-deficient, but not peptide YY- resistant, state.
Young AA. Young AA. Endocrinology. 2006 Jan;147(1):1-2. doi: 10.1210/en.2005-1217. Endocrinology. 2006. PMID: 16365139 No abstract available.
Boc5, a non-peptidic glucagon-like Peptide-1 receptor agonist, invokes sustained glycemic control and weight loss in diabetic mice.
Su H, He M, Li H, Liu Q, Wang J, Wang Y, Gao W, Zhou L, Liao J, Young AA, Wang MW. Su H, et al. Among authors: young aa. PLoS One. 2008 Aug 6;3(8):e2892. doi: 10.1371/journal.pone.0002892. PLoS One. 2008. PMID: 18682834 Free PMC article.
A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice.
Chen D, Liao J, Li N, Zhou C, Liu Q, Wang G, Zhang R, Zhang S, Lin L, Chen K, Xie X, Nan F, Young AA, Wang MW. Chen D, et al. Among authors: young aa. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):943-8. doi: 10.1073/pnas.0610173104. Epub 2007 Jan 9. Proc Natl Acad Sci U S A. 2007. PMID: 17213311 Free PMC article.
Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes.
Chen L, Yao X, Young A, McNulty J, Anderson D, Liu Y, Nystrom C, Croom D, Ross S, Collins J, Rajpal D, Hamlet K, Smith C, Gedulin B. Chen L, et al. Am J Physiol Endocrinol Metab. 2012 Jan 1;302(1):E68-76. doi: 10.1152/ajpendo.00323.2011. Epub 2011 Sep 20. Am J Physiol Endocrinol Metab. 2012. PMID: 21934041
Cholestyramine reverses hyperglycemia and enhances glucose-stimulated glucagon-like peptide 1 release in Zucker diabetic fatty rats.
Chen L, McNulty J, Anderson D, Liu Y, Nystrom C, Bullard S, Collins J, Handlon AL, Klein R, Grimes A, Murray D, Brown R, Krull D, Benson B, Kleymenova E, Remlinger K, Young A, Yao X. Chen L, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):164-70. doi: 10.1124/jpet.110.166892. Epub 2010 Apr 22. J Pharmacol Exp Ther. 2010. PMID: 20413600
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