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Myeloid-derived suppressor cell inhibition of the IFN response in tumor-bearing mice.
Mundy-Bosse BL, Lesinski GB, Jaime-Ramirez AC, Benninger K, Khan M, Kuppusamy P, Guenterberg K, Kondadasula SV, Chaudhury AR, La Perle KM, Kreiner M, Young G, Guttridge DC, Carson WE 3rd. Mundy-Bosse BL, et al. Among authors: young g. Cancer Res. 2011 Aug 1;71(15):5101-10. doi: 10.1158/0008-5472.CAN-10-2670. Epub 2011 Jun 16. Cancer Res. 2011. PMID: 21680779 Free PMC article.
IFN-alpha and bortezomib overcome Bcl-2 and Mcl-1 overexpression in melanoma cells by stimulating the extrinsic pathway of apoptosis.
Lesinski GB, Raig ET, Guenterberg K, Brown L, Go MR, Shah NN, Lewis A, Quimper M, Hade E, Young G, Chaudhury AR, Ladner KJ, Guttridge DC, Bouchard P, Carson WE 3rd. Lesinski GB, et al. Among authors: young g. Cancer Res. 2008 Oct 15;68(20):8351-60. doi: 10.1158/0008-5472.CAN-08-0426. Cancer Res. 2008. PMID: 18922907 Free PMC article.
The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity.
Bill MA, Fuchs JR, Li C, Yui J, Bakan C, Benson DM Jr, Schwartz EB, Abdelhamid D, Lin J, Hoyt DG, Fossey SL, Young GS, Carson WE 3rd, Li PK, Lesinski GB. Bill MA, et al. Among authors: young gs. Mol Cancer. 2010 Jun 25;9:165. doi: 10.1186/1476-4598-9-165. Mol Cancer. 2010. PMID: 20576164 Free PMC article.
Distinct myeloid suppressor cell subsets correlate with plasma IL-6 and IL-10 and reduced interferon-alpha signaling in CD4⁺ T cells from patients with GI malignancy.
Mundy-Bosse BL, Young GS, Bauer T, Binkley E, Bloomston M, Bill MA, Bekaii-Saab T, Carson WE 3rd, Lesinski GB. Mundy-Bosse BL, et al. Cancer Immunol Immunother. 2011 Sep;60(9):1269-79. doi: 10.1007/s00262-011-1029-z. Epub 2011 May 21. Cancer Immunol Immunother. 2011. PMID: 21604071 Free PMC article.
3,125 results