Young RN - Search Results

1

A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B.

Bosc D, Vezenkov L, Bortnik S, An J, Xu J, Choutka C, Hannigan AM, Kovacic S, Loo S, Clark PGK, Chen G, Guay-Ross RN, Yang K, Dragowska WH, Zhang F, Go NE, Leung A, Honson NS, Pfeifer TA, Gleave M, Bally M, Jones SJ, Gorski SM, Young RN. Bosc D, et al. Among authors: young rn. Sci Rep. 2018 Aug 3;8(1):11653. doi: 10.1038/s41598-018-29900-x. Sci Rep. 2018. PMID: 30076329 Free PMC article.

2

Autophagy: from structure to metabolism to therapeutic regulation.

Jardon MA, Rothe K, Bortnik S, Vezenkov L, Jiang X, Young RN, Lum JJ, Gorski SM. Jardon MA, et al. Among authors: young rn. Autophagy. 2013 Dec;9(12):2180-2. doi: 10.4161/auto.26378. Epub 2013 Sep 30. Autophagy. 2013. PMID: 24201076

3

Development of fluorescent substrates and assays for the key autophagy-related cysteine protease enzyme, ATG4B.

Nguyen TG, Honson NS, Arns S, Davis TL, Dhe-Paganon S, Kovacic S, Kumar NS, Pfeifer TA, Young RN. Nguyen TG, et al. Among authors: young rn. Assay Drug Dev Technol. 2014 Apr;12(3):176-89. doi: 10.1089/adt.2013.561. Assay Drug Dev Technol. 2014. PMID: 24735444 Free PMC article.

4

Determination of the rat in vivo pharmacokinetic profile of a bone-targeting dual-action pro-drug for treatment of osteoporosis.

Chen G, Arns S, Young RN. Chen G, et al. Among authors: young rn. Bioconjug Chem. 2015 Jun 17;26(6):1095-103. doi: 10.1021/acs.bioconjchem.5b00160. Epub 2015 May 15. Bioconjug Chem. 2015. PMID: 25945831

5

Development of fluorescent peptide substrates and assays for the key autophagy-initiating cysteine protease enzyme, ATG4B.

Vezenkov L, Honson NS, Kumar NS, Bosc D, Kovacic S, Nguyen TG, Pfeifer TA, Young RN. Vezenkov L, et al. Among authors: young rn. Bioorg Med Chem. 2015 Jul 1;23(13):3237-47. doi: 10.1016/j.bmc.2015.04.064. Epub 2015 Apr 28. Bioorg Med Chem. 2015. PMID: 25979376

6

In vivo effects of two novel ALN-EP4a conjugate drugs on bone in the ovariectomized rat model for reversing postmenopausal bone loss.

Hu S, Liu CC, Chen G, Willett T, Young RN, Grynpas MD. Hu S, et al. Among authors: young rn. Osteoporos Int. 2016 Feb;27(2):797-808. doi: 10.1007/s00198-015-3284-x. Epub 2015 Aug 14. Osteoporos Int. 2016. PMID: 26272313

7

Precision autophagy: Will the next wave of selective autophagy markers and specific autophagy inhibitors feed clinical pipelines?

Lebovitz CB, DeVorkin L, Bosc D, Rothe K, Singh J, Bally M, Jiang X, Young RN, Lum JJ, Gorski SM. Lebovitz CB, et al. Among authors: young rn. Autophagy. 2015;11(10):1949-52. doi: 10.1080/15548627.2015.1078962. Autophagy. 2015. PMID: 26506897 Free PMC article.

8

Design, Synthesis, and Pharmacokinetics of a Bone-Targeting Dual-Action Prodrug for the Treatment of Osteoporosis.

Xie H, Chen G, Young RN. Xie H, et al. Among authors: young rn. J Med Chem. 2017 Aug 24;60(16):7012-7028. doi: 10.1021/acs.jmedchem.6b00951. Epub 2017 Aug 10. J Med Chem. 2017. PMID: 28699744

9

Effects of treatment with a bone-targeted prostaglandin E2 receptor 4 agonist C3 (Mes-1007) in a mouse model of severe osteogenesis imperfecta.

Boraschi-Diaz I, Chen G, Polak-Nachumow J, Young RN, Rauch F. Boraschi-Diaz I, et al. Among authors: young rn. Bone. 2021 Apr;145:115867. doi: 10.1016/j.bone.2021.115867. Epub 2021 Jan 29. Bone. 2021. PMID: 33524637

10

Development of 2-(5,6,7-Trifluoro-1H-Indol-3-yl)-quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Prostate Cancer.

Leblanc E, Ban F, Cavga AD, Lawn S, Huang CF, Mohan S, Chang MEK, Flory MR, Ghaidi F, Lingadahalli S, Chen G, Yu IPL, Morin H, Lallous N, Gleave ME, Mohammed H, Young RN, Rennie PS, Lack NA, Cherkasov A. Leblanc E, et al. Among authors: young rn. J Med Chem. 2021 Oct 28;64(20):14968-14982. doi: 10.1021/acs.jmedchem.1c00681. Epub 2021 Oct 18. J Med Chem. 2021. PMID: 34661404

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