Young SG - Search Results

1

Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect.

Verstraeten VL, Peckham LA, Olive M, Capell BC, Collins FS, Nabel EG, Young SG, Fong LG, Lammerding J. Verstraeten VL, et al. Among authors: young sg. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4997-5002. doi: 10.1073/pnas.1019532108. Epub 2011 Mar 7. Proc Natl Acad Sci U S A. 2011. PMID: 21383178 Free PMC article.

2

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice.

Fong LG, Ng JK, Meta M, Coté N, Yang SH, Stewart CL, Sullivan T, Burghardt A, Majumdar S, Reue K, Bergo MO, Young SG. Fong LG, et al. Among authors: young sg. Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18111-6. doi: 10.1073/pnas.0408558102. Epub 2004 Dec 17. Proc Natl Acad Sci U S A. 2004. PMID: 15608054 Free PMC article.

3

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

Yang SH, Bergo MO, Toth JI, Qiao X, Hu Y, Sandoval S, Meta M, Bendale P, Gelb MH, Young SG, Fong LG. Yang SH, et al. Among authors: young sg. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10291-6. doi: 10.1073/pnas.0504641102. Epub 2005 Jul 12. Proc Natl Acad Sci U S A. 2005. PMID: 16014412 Free PMC article.

4

Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes.

Toth JI, Yang SH, Qiao X, Beigneux AP, Gelb MH, Moulson CL, Miner JH, Young SG, Fong LG. Toth JI, et al. Among authors: young sg. Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12873-8. doi: 10.1073/pnas.0505767102. Epub 2005 Aug 29. Proc Natl Acad Sci U S A. 2005. PMID: 16129834 Free PMC article.

5

Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis.

Young SG, Fong LG, Michaelis S. Young SG, et al. J Lipid Res. 2005 Dec;46(12):2531-58. doi: 10.1194/jlr.R500011-JLR200. Epub 2005 Oct 5. J Lipid Res. 2005. PMID: 16207929 Free article. Review.

6

A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, Young SG. Fong LG, et al. Among authors: young sg. Science. 2006 Mar 17;311(5767):1621-3. doi: 10.1126/science.1124875. Epub 2006 Feb 16. Science. 2006. PMID: 16484451

7

Prelamin A and lamin A appear to be dispensable in the nuclear lamina.

Fong LG, Ng JK, Lammerding J, Vickers TA, Meta M, Coté N, Gavino B, Qiao X, Chang SY, Young SR, Yang SH, Stewart CL, Lee RT, Bennett CF, Bergo MO, Young SG. Fong LG, et al. Among authors: young sr, young sg. J Clin Invest. 2006 Mar;116(3):743-52. doi: 10.1172/JCI27125. J Clin Invest. 2006. PMID: 16511604 Free PMC article.

8

Lamins A and C but not lamin B1 regulate nuclear mechanics.

Lammerding J, Fong LG, Ji JY, Reue K, Stewart CL, Young SG, Lee RT. Lammerding J, et al. Among authors: young sg. J Biol Chem. 2006 Sep 1;281(35):25768-80. doi: 10.1074/jbc.M513511200. Epub 2006 Jul 5. J Biol Chem. 2006. PMID: 16825190 Free article.

9

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

Yang SH, Meta M, Qiao X, Frost D, Bauch J, Coffinier C, Majumdar S, Bergo MO, Young SG, Fong LG. Yang SH, et al. Among authors: young sg. J Clin Invest. 2006 Aug;116(8):2115-21. doi: 10.1172/JCI28968. J Clin Invest. 2006. PMID: 16862216 Free PMC article.

10

Protein farnesyltransferase inhibitors and progeria.

Meta M, Yang SH, Bergo MO, Fong LG, Young SG. Meta M, et al. Among authors: young sg. Trends Mol Med. 2006 Oct;12(10):480-7. doi: 10.1016/j.molmed.2006.08.006. Epub 2006 Aug 30. Trends Mol Med. 2006. PMID: 16942914 Review.

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