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An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee.
Huggins JP, Smart TS, Langman S, Taylor L, Young T. Huggins JP, et al. Among authors: young t. Pain. 2012 Sep;153(9):1837-1846. doi: 10.1016/j.pain.2012.04.020. Epub 2012 Jun 21. Pain. 2012. PMID: 22727500 Clinical Trial.
Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.
Ahn K, Smith SE, Liimatta MB, Beidler D, Sadagopan N, Dudley DT, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stiff C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt BF. Ahn K, et al. Among authors: young t. J Pharmacol Exp Ther. 2011 Jul;338(1):114-24. doi: 10.1124/jpet.111.180257. Epub 2011 Apr 19. J Pharmacol Exp Ther. 2011. PMID: 21505060 Free PMC article.
Optimisation of a novel series of selective CNS penetrant CB(2) agonists.
Watson C, Owen DR, Harding D, Kon-I K, Lewis ML, Mason HJ, Matsumizu M, Mukaiyama T, Rodriguez-Lens M, Shima A, Takeuchi M, Tran I, Young T. Watson C, et al. Among authors: young t. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4284-7. doi: 10.1016/j.bmcl.2011.05.063. Epub 2011 May 25. Bioorg Med Chem Lett. 2011. PMID: 21669533
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