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Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors.
Landry LG, Anderson AM, Russ HA, Yu L, Kent SC, Atkinson MA, Mathews CE, Michels AW, Nakayama M. Landry LG, et al. Among authors: yu l. Front Endocrinol (Lausanne). 2021 Mar 25;12:622647. doi: 10.3389/fendo.2021.622647. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 33841327 Free PMC article.
Conserved T cell receptor alpha-chain induces insulin autoantibodies.
Kobayashi M, Jasinski J, Liu E, Li M, Miao D, Zhang L, Yu L, Nakayama M, Eisenbarth GS. Kobayashi M, et al. Among authors: yu l. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10090-4. doi: 10.1073/pnas.0801648105. Epub 2008 Jul 14. Proc Natl Acad Sci U S A. 2008. PMID: 18626021 Free PMC article.
Type 1 diabetes: chronic progressive autoimmune disease.
Zhang L, Gianani R, Nakayama M, Liu E, Kobayashi M, Baschal E, Yu L, Babu S, Dawson A, Johnson K, Jahromi M, Aly T, Fain P, Barker J, Rewers M, Eisenbarth GS. Zhang L, et al. Among authors: yu l. Novartis Found Symp. 2008;292:85-94; discussion 94-8, 122-9, 202-3. doi: 10.1002/9780470697405.ch7. Novartis Found Symp. 2008. PMID: 19203094
Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial.
Orban T, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JB, Monzavi R, Moran A, Raskin P, Rodriguez H, Russell WE, Schatz D, Wherrett D, Wilson DM, Krischer JP, Skyler JS; Type 1 Diabetes TrialNet Abatacept Study Group. Orban T, et al. Lancet. 2011 Jul 30;378(9789):412-9. doi: 10.1016/S0140-6736(11)60886-6. Epub 2011 Jun 28. Lancet. 2011. PMID: 21719096 Free PMC article. Clinical Trial.
Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies.
Yu L, Boulware DC, Beam CA, Hutton JC, Wenzlau JM, Greenbaum CJ, Bingley PJ, Krischer JP, Sosenko JM, Skyler JS, Eisenbarth GS, Mahon JL; Type 1 Diabetes TrialNet Study Group. Yu L, et al. Diabetes Care. 2012 Jun;35(6):1213-8. doi: 10.2337/dc11-2081. Epub 2012 Mar 23. Diabetes Care. 2012. PMID: 22446173 Free PMC article.
Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes.
Roep BO, Solvason N, Gottlieb PA, Abreu JRF, Harrison LC, Eisenbarth GS, Yu L, Leviten M, Hagopian WA, Buse JB, von Herrath M, Quan J, King RS, Robinson WH, Utz PJ, Garren H; BHT-3021 Investigators; Steinman L. Roep BO, et al. Among authors: yu l. Sci Transl Med. 2013 Jun 26;5(191):191ra82. doi: 10.1126/scitranslmed.3006103. Sci Transl Med. 2013. PMID: 23803704 Free PMC article. Clinical Trial.
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