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Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells.
Yuan L, Wei S, Wang J, Liu X. Yuan L, et al. J Agric Food Chem. 2014 Jun 11;62(23):5390-400. doi: 10.1021/jf500903g. Epub 2014 Jun 3. J Agric Food Chem. 2014. PMID: 24841907
Also, the reactive oxygen species (ROS) inhibitor N-acetyl-L-cysteine (NAC), the JNK inhibitor SP600125, and the p38 inhibitor SB203580 efficiently downregulated the levels of these proteins. ...
Also, the reactive oxygen species (ROS) inhibitor N-acetyl-L-cysteine (NAC), the JNK inhibitor SP600125, and the p38 inhibitor SB2035 …
Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells.
Yuan L, Wang J, Xiao H, Xiao C, Wang Y, Liu X. Yuan L, et al. Toxicol Appl Pharmacol. 2012 Nov 15;265(1):83-92. doi: 10.1016/j.taap.2012.09.022. Epub 2012 Sep 28. Toxicol Appl Pharmacol. 2012. PMID: 23026832
Herbacetin induces apoptosis in HepG2 cells: Involvements of ROS and PI3K/Akt pathway.
Qiao Y, Xiang Q, Yuan L, Xu L, Liu Z, Liu X. Qiao Y, et al. Food Chem Toxicol. 2013 Jan;51:426-33. doi: 10.1016/j.fct.2012.09.036. Epub 2012 Oct 12. Food Chem Toxicol. 2013. PMID: 23063593
Furthermore, the addition of a ROS inhibitor (N-Acetyl-l-cysteine, NAC) significantly attenuated the apoptosis induced by HER and also blocked the expression of PGC-1α protein. ...
Furthermore, the addition of a ROS inhibitor (N-Acetyl-l-cysteine, NAC) significantly attenuated the apoptosis induced by HER and als …
Momordin Ic induces HepG2 cell apoptosis through MAPK and PI3K/Akt-mediated mitochondrial pathways.
Wang J, Yuan L, Xiao H, Xiao C, Wang Y, Liu X. Wang J, et al. Apoptosis. 2013 Jun;18(6):751-65. doi: 10.1007/s10495-013-0820-z. Apoptosis. 2013. PMID: 23417763
Momordin Ic is a natural triterpenoid saponin enriched in various Chinese and Japanese natural medicines such as the fruit of Kochia scoparia (L.) ...
Momordin Ic is a natural triterpenoid saponin enriched in various Chinese and Japanese natural medicines such as the fruit of Kochia scopari …
Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-κB signaling pathway in BV-2 microglia.
Yuan L, Wu Y, Ren X, Liu Q, Wang J, Liu X. Yuan L, et al. Mol Cell Biochem. 2014 Jan;386(1-2):153-65. doi: 10.1007/s11010-013-1854-9. Epub 2013 Oct 11. Mol Cell Biochem. 2014. PMID: 24114663
A novel mechanism for momordin Ic-induced HepG2 apoptosis: involvement of PI3K- and MAPK-dependent PPARγ activation.
Wang J, Yuan L, Xiao H, Wang C, Xiao C, Wang Y, Liu X. Wang J, et al. Food Funct. 2014 May;5(5):859-68. doi: 10.1039/c3fo60558b. Food Funct. 2014. PMID: 24584198
Momordin Ic is a natural triterpenoid saponin found in various Chinese and Japanese natural medicines such as the fruit of Kochia scoparia (L.) ...
Momordin Ic is a natural triterpenoid saponin found in various Chinese and Japanese natural medicines such as the fruit of Kochia scoparia ( …
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