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Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me).
Yue P, Zhou Z, Khuri FR, Sun SY. Yue P, et al. Cancer Biol Ther. 2006 May;5(5):492-7. doi: 10.4161/cbt.5.5.2565. Epub 2006 May 2. Cancer Biol Ther. 2006. PMID: 16582599
DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion.
Oh YT, Yue P, Sun SY. Oh YT, et al. Among authors: yue p. Cell Commun Signal. 2017 May 8;15(1):18. doi: 10.1186/s12964-017-0174-1. Cell Commun Signal. 2017. PMID: 28482915 Free PMC article.
Expression of Death Receptor 4 Is Positively Regulated by MEK/ERK/AP-1 Signaling and Suppressed upon MEK Inhibition.
Yao W, Oh YT, Deng J, Yue P, Deng L, Huang H, Zhou W, Sun SY. Yao W, et al. Among authors: yue p. J Biol Chem. 2016 Oct 7;291(41):21694-21702. doi: 10.1074/jbc.M116.738302. Epub 2016 Aug 30. J Biol Chem. 2016. PMID: 27576686 Free PMC article.
Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling.
Oh YT, Yue P, Zhou W, Balko JM, Black EP, Owonikoko TK, Khuri FR, Sun SY. Oh YT, et al. Among authors: yue p. J Biol Chem. 2012 Jan 2;287(1):257-67. doi: 10.1074/jbc.M111.304006. Epub 2011 Nov 7. J Biol Chem. 2012. PMID: 22065586 Free PMC article.
Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.
Li Y, Yue P, Deng X, Ueda T, Fukunaga R, Khuri FR, Sun SY. Li Y, et al. Among authors: yue p. Neoplasia. 2010 Oct;12(10):848-55. doi: 10.1593/neo.10704. Neoplasia. 2010. PMID: 20927323 Free PMC article.
Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation.
Wang X, Yue P, Chan CB, Ye K, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Fu H, Khuri FR, Sun SY. Wang X, et al. Among authors: yue p. Mol Cell Biol. 2007 Nov;27(21):7405-13. doi: 10.1128/MCB.00760-07. Epub 2007 Aug 27. Mol Cell Biol. 2007. PMID: 17724079 Free PMC article.
c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells.
Zou W, Chen S, Liu X, Yue P, Sporn MB, Khuri FR, Sun SY. Zou W, et al. Among authors: yue p. Cancer Biol Ther. 2007 Oct;6(10):1614-20. doi: 10.4161/cbt.6.10.4763. Epub 2007 Jul 19. Cancer Biol Ther. 2007. PMID: 18253090
The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosis.
Ren H, Zhao L, Li Y, Yue P, Deng X, Owonikoko TK, Chen M, Khuri FR, Sun SY. Ren H, et al. Among authors: yue p. Cancer Lett. 2013 Sep 28;338(2):229-38. doi: 10.1016/j.canlet.2013.03.032. Epub 2013 Apr 2. Cancer Lett. 2013. PMID: 23562472 Free PMC article.
mTOR complex 2 is involved in regulation of Cbl-dependent c-FLIP degradation and sensitivity of TRAIL-induced apoptosis.
Zhao L, Yue P, Khuri FR, Sun SY. Zhao L, et al. Among authors: yue p. Cancer Res. 2013 Mar 15;73(6):1946-57. doi: 10.1158/0008-5472.CAN-12-3710. Epub 2013 Jan 14. Cancer Res. 2013. PMID: 23319802 Free PMC article.
Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells.
Liu X, Yue P, Schönthal AH, Khuri FR, Sun SY. Liu X, et al. Among authors: yue p. Cancer Res. 2006 Dec 1;66(23):11115-9. doi: 10.1158/0008-5472.CAN-06-2471. Cancer Res. 2006. PMID: 17145853
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