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Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation.
Yuen CK, Chan CP, Fung SY, Wang PH, Wong WM, Tang HV, Yuen KS, Chan CP, Jin DY, Kok KH. Yuen CK, et al. J Virol. 2016 Mar 28;90(8):3902-3912. doi: 10.1128/JVI.00129-16. Print 2016 Apr. J Virol. 2016. PMID: 26819312 Free PMC article.
The expression of Tax alone sufficiently repressed the induction of IFN production by RIG-I plus PACT, cGAMP synthase plus STING, TBK1, IKKepsilon, IRF3, and IRF7, but not by IRF3-5D, a dominant-active phosphomimetic mutant. This suggests that Tax perturbs IFN production a …
The expression of Tax alone sufficiently repressed the induction of IFN production by RIG-I plus PACT, cGAMP synthase plus STING, TBK1, IKKe …