Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2015 1
2017 1
2018 3
2019 2
2022 1
2024 1
2025 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

9 results

Results by year

Filters applied: . Clear all
Page 1
Transcriptome Analysis of Canine Histiocytic Sarcoma Tumors and Cell Lines Reveals Multiple Targets for Therapy.
Engleberg AI, Yang YT, Schall PZ, Takada M, Thaiwong-Nebelung T, Evans JM, Ostrander EA, Yuzbasiyan-Gurkan V. Engleberg AI, et al. Among authors: yuzbasiyan gurkan v. Cancers (Basel). 2025 Mar 12;17(6):954. doi: 10.3390/cancers17060954. Cancers (Basel). 2025. PMID: 40149290 Free PMC article.
Background: Histiocytic sarcoma (HS) is a highly aggressive malignancy characterized by the excessive proliferation of histiocytes in dogs and humans. ...
Background: Histiocytic sarcoma (HS) is a highly aggressive malignancy characterized by the excessive proliferation of histioc …
Canine Histiocytic and Hemophagocytic Histiocytic Sarcomas Display KRAS and Extensive PTPN11/SHP2 Mutations and Respond In Vitro to MEK Inhibition by Cobimetinib.
Yang YT, Engleberg AI, Kapoor I, Kitagawa K, Hilburger SA, Thaiwong-Nebelung T, Yuzbasiyan-Gurkan V. Yang YT, et al. Among authors: yuzbasiyan gurkan v. Genes (Basel). 2024 Aug 9;15(8):1050. doi: 10.3390/genes15081050. Genes (Basel). 2024. PMID: 39202410 Free PMC article.
Histiocytic sarcoma (HS) is a rare and highly aggressive cancer in humans and dogs. In dogs, it has a high prevalence in certain breeds, such as Bernese mountain dogs (BMDs) and flat-coated retrievers. Hemophagocytic histiocytic sarcoma (HHS) is a uniq …
Histiocytic sarcoma (HS) is a rare and highly aggressive cancer in humans and dogs. In dogs, it has a high prevalence in certa …
Identification of a Hypomorphic FANCG Variant in Bernese Mountain Dogs.
Meek K, Yang YT, Takada M, Parys M, Richter M, Engleberg AI, Thaiwong T, Griffin RL, Schall PZ, Kramer AJ, Yuzbasiyan-Gurkan V. Meek K, et al. Among authors: yuzbasiyan gurkan v. Genes (Basel). 2022 Sep 21;13(10):1693. doi: 10.3390/genes13101693. Genes (Basel). 2022. PMID: 36292578 Free PMC article.
Bernese mountain dogs (BMDs), have an overall cancer incidence of 50%, half of which is comprised of an otherwise rare tumor, histiocytic sarcoma (HS). While recent studies have identified driver mutations in the MAPK pathway, identification of key predisposing gene …
Bernese mountain dogs (BMDs), have an overall cancer incidence of 50%, half of which is comprised of an otherwise rare tumor, histiocytic …
Activating Mutations in PTPN11 and KRAS in Canine Histiocytic Sarcomas.
Takada M, Smyth LA, Thaiwong T, Richter M, Corner SM, Schall PZ, Kiupel M, Yuzbasiyan-Gurkan V. Takada M, et al. Among authors: yuzbasiyan gurkan v. Genes (Basel). 2019 Jul 4;10(7):505. doi: 10.3390/genes10070505. Genes (Basel). 2019. PMID: 31277422 Free PMC article.
While the genetic contributions to the predisposition of Bernese mountain dogs (BMDs) to histiocytic sarcoma (HS) remains unclear, some insights into key genetic drivers have been gained. ...
While the genetic contributions to the predisposition of Bernese mountain dogs (BMDs) to histiocytic sarcoma (HS) remains uncl …
Development of an Orthotopic Intrasplenic Xenograft Mouse Model of Canine Histiocytic Sarcoma and Its Use in Evaluating the Efficacy of Treatment with Dasatinib.
Takada M, Smyth LA, Hix JM, Corner SM, Kiupel M, Yuzbasiyan-Gurkan V. Takada M, et al. Among authors: yuzbasiyan gurkan v. Comp Med. 2019 Feb 1;69(1):22-28. doi: 10.30802/AALAS-CM-18-000065. Epub 2019 Feb 4. Comp Med. 2019. PMID: 30717820 Free PMC article.
Canine histiocytic sarcoma is a highly aggressive and metastatic hematopoietic neoplasm that responds poorly to currently available treatment regimens. ...Our findings indicate the potential of dasatinib for the treatment of histiocytic sarcoma in dogs …
Canine histiocytic sarcoma is a highly aggressive and metastatic hematopoietic neoplasm that responds poorly to currently avai …
Targeting MEK in a Translational Model of Histiocytic Sarcoma.
Takada M, Hix JML, Corner S, Schall PZ, Kiupel M, Yuzbasiyan-Gurkan V. Takada M, et al. Among authors: yuzbasiyan gurkan v. Mol Cancer Ther. 2018 Nov;17(11):2439-2450. doi: 10.1158/1535-7163.MCT-17-1273. Epub 2018 Aug 22. Mol Cancer Ther. 2018. PMID: 30135215
Histiocytic sarcoma in humans is an aggressive orphan disease with a poor prognosis as treatment options are limited. ...Furthermore, in vitro findings were successfully recapitulated in an intrasplenic orthotopic xenograft mouse model, which represents a disseminat …
Histiocytic sarcoma in humans is an aggressive orphan disease with a poor prognosis as treatment options are limited. ...Furth …
A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies.
Takada M, Parys M, Gregory-Bryson E, Vilar Saavedra P, Kiupel M, Yuzbasiyan-Gurkan V. Takada M, et al. Among authors: yuzbasiyan gurkan v. BMC Cancer. 2018 Mar 1;18(1):237. doi: 10.1186/s12885-018-4132-0. BMC Cancer. 2018. PMID: 29490634 Free PMC article.
BACKGROUND: Histiocytic sarcoma is a rare disorder in humans, however it is seen with appreciable frequency in certain breeds of dogs, such as Bernese mountain dog. The purpose of this study was to fully characterize a novel canine histiocytic sarcoma …
BACKGROUND: Histiocytic sarcoma is a rare disorder in humans, however it is seen with appreciable frequency in certain breeds …
Gain-of-function mutation in PTPN11 in histiocytic sarcomas of Bernese Mountain Dogs.
Thaiwong T, Sirivisoot S, Takada M, Yuzbasiyan-Gurkan V, Kiupel M. Thaiwong T, et al. Among authors: yuzbasiyan gurkan v. Vet Comp Oncol. 2018 Jun;16(2):220-228. doi: 10.1111/vco.12357. Epub 2017 Sep 20. Vet Comp Oncol. 2018. PMID: 28929581
Histiocytic sarcoma (HS) is an aggressive malignant neoplasm of dendritic cell origin that is common in certain breeds of dogs. ...Recently, E76K gain-of-function mutation in SHP2 encoded by the PTPN11 gene has been described in human histiocytic malignancies …
Histiocytic sarcoma (HS) is an aggressive malignant neoplasm of dendritic cell origin that is common in certain breeds of dogs …
Comparison of FTIR transmission and transfection substrates for canine liver cancer detection.
Kochan K, Heraud P, Kiupel M, Yuzbasiyan-Gurkan V, McNaughton D, Baranska M, Wood BR. Kochan K, et al. Among authors: yuzbasiyan gurkan v. Analyst. 2015 Apr 7;140(7):2402-11. doi: 10.1039/c4an01901f. Analyst. 2015. PMID: 25502543
In this paper we present a comparison of the two most common FT-IR measurement modes: transmission and transfection using healthy and pathologically altered tissue (histiocytic sarcoma). We found that the major differences between normal and cancerous tissue were as …
In this paper we present a comparison of the two most common FT-IR measurement modes: transmission and transfection using healthy and pathol …