Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1987 1
1988 1
1990 1
1991 4
1993 1
1994 1
1995 1
1997 1
1998 2
2000 2
2001 1
2002 4
2003 4
2004 10
2005 3
2006 7
2007 8
2008 9
2009 17
2010 10
2011 20
2012 13
2013 17
2014 13
2015 19
2016 17
2017 20
2018 22
2019 25
2020 27
2021 31
2022 33
2023 39
2024 27
2025 29

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

368 results

Results by year

Filters applied: . Clear all
Page 1
Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity.
Zhao C, Ma Y, Zhang M, Gao X, Liang W, Qin Y, Fu Y, Jia M, Song H, Gao C, Zhao W. Zhao C, et al. Among authors: zhang m. Immunity. 2023 Nov 14;56(11):2508-2522.e6. doi: 10.1016/j.immuni.2023.09.012. Epub 2023 Oct 16. Immunity. 2023. PMID: 37848037 Free article.
Mechanistically, spermine and spermidine induced the transition of B-form DNA to Z-form DNA (Z-DNA), thereby decreasing its binding affinity with cGAS. Spermidine/spermine N1-acetyltransferase 1 (SAT1), the rate-limiting enzyme in polyamine catabolism that decreases …
Mechanistically, spermine and spermidine induced the transition of B-form DNA to Z-form DNA (Z-DNA), thereby decreasing its bi …
Role of histone H3 lysine 27 methylation in Polycomb-group silencing.
Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y. Cao R, et al. Among authors: zhang y. Science. 2002 Nov 1;298(5595):1039-43. doi: 10.1126/science.1076997. Epub 2002 Sep 26. Science. 2002. PMID: 12351676
Here we report the purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex. We demonstrate that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27). Using chromatin immunoprecipitation …
Here we report the purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex …
ZBP1 senses splicing aberration through Z-RNA to promote cell death.
Yang ZH, Wu P, Zhang BX, Yang CR, Huang J, Wu L, Guo SH, Zhou Y, Mao Y, Yin Y, Wu X, Cheng P, Li B, Zhou R, Shen HM, Nie S, Cai ZY, Mo W. Yang ZH, et al. Among authors: zhang bx. Mol Cell. 2025 May 1;85(9):1775-1789.e5. doi: 10.1016/j.molcel.2025.03.023. Epub 2025 Apr 22. Mol Cell. 2025. PMID: 40267920
Here, we demonstrate that spliceosome inhibition induces the widespread formation of left-handed Z-form double-stranded RNA (Z-RNA), predominantly derived from mis-spliced exonic and intronic RNA transcripts in the nucleus. These Z-RNAs are exported to the cy …
Here, we demonstrate that spliceosome inhibition induces the widespread formation of left-handed Z-form double-stranded RNA (Z …
H2A.Z facilitates licensing and activation of early replication origins.
Long H, Zhang L, Lv M, Wen Z, Zhang W, Chen X, Zhang P, Li T, Chang L, Jin C, Wu G, Wang X, Yang F, Pei J, Chen P, Margueron R, Deng H, Zhu M, Li G. Long H, et al. Among authors: zhang l, zhang p, zhang w. Nature. 2020 Jan;577(7791):576-581. doi: 10.1038/s41586-019-1877-9. Epub 2019 Dec 25. Nature. 2020. PMID: 31875854
Genome-wide studies show that signals from H4K20me2, ORC1 and nascent DNA strands co-localize with H2A.Z, and that depletion of H2A.Z results in decreased H4K20me2, ORC1 and nascent-strand signals throughout the genome. H2A.Z-regulated replication origins hav …
Genome-wide studies show that signals from H4K20me2, ORC1 and nascent DNA strands co-localize with H2A.Z, and that depletion of H2A. …
Spliceosome inhibition induces Z-RNA and ZBP1-driven cell death in small cell lung cancer.
Jiang X, Ma X, Zhou Y, Liu X, Zhang T, Kim W, Balachandran S, Cañadas I. Jiang X, et al. Among authors: zhang t. Cell Rep. 2025 Oct 28;44(10):116384. doi: 10.1016/j.celrep.2025.116384. Epub 2025 Oct 4. Cell Rep. 2025. PMID: 41046514 Free article.
Here, we show that spliceosome inhibition by pharmacological or genetic neutralization of SF3B1 activity induces the accumulation of endogenous left-handed dsRNAs (Z-RNAs) derived from intron-retained RNAs. These Z-RNAs activate the Z-form nucleic acid-sensor …
Here, we show that spliceosome inhibition by pharmacological or genetic neutralization of SF3B1 activity induces the accumulation of endogen …
Characterization of Z-DNA by Infrared Spectroscopy.
Zhang F, Huang Q. Zhang F, et al. Methods Mol Biol. 2023;2651:53-58. doi: 10.1007/978-1-0716-3084-6_3. Methods Mol Biol. 2023. PMID: 36892758
Here we describe the method of application of infrared spectroscopy in the investigation of Z-DNA in cells, as infrared spectroscopy can distinguish DNA secondary structures sensitively and the band at 930 cm(-1) is specifically attributed to the Z-form DNA. Based o …
Here we describe the method of application of infrared spectroscopy in the investigation of Z-DNA in cells, as infrared spectroscopy …
Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1.
Wang Z, Zhang D, Qiu X, Inuzuka H, Xiong Y, Liu J, Chen L, Chen H, Xie L, Kaniskan HÜ, Chen X, Jin J, Wei W. Wang Z, et al. Among authors: zhang d. J Am Chem Soc. 2024 Mar 20;146(11):7584-7593. doi: 10.1021/jacs.3c13646. Epub 2024 Mar 12. J Am Chem Soc. 2024. PMID: 38469801 Free PMC article.
The core of our innovation lies in the strategic engagement of Z-form DNA with ADAR1 and its degradation is achieved by leveraging a VHL ligand conjugated to Z-form DNA to recruit the E3 ligase. ...In summary, the Z-DNA-based PROTAC (Z-PROTAC) approach …
The core of our innovation lies in the strategic engagement of Z-form DNA with ADAR1 and its degradation is achieved by leveraging a …
Detecting Z-RNA and Z-DNA in Mammalian Cells.
Yin C, Zhang T, Balachandran S. Yin C, et al. Among authors: zhang t. Methods Mol Biol. 2023;2651:277-284. doi: 10.1007/978-1-0716-3084-6_19. Methods Mol Biol. 2023. PMID: 36892774
Z-RNA is detected by Zalpha domain containing PRRs, including Z-form nucleic acid binding protein 1 (ZBP1) and the p150 subunit of adenosine deaminase RNA specific 1 (ADAR1). ...In this chapter, we describe our procedure for detecting Z-RNA in influenza A vir …
Z-RNA is detected by Zalpha domain containing PRRs, including Z-form nucleic acid binding protein 1 (ZBP1) and the p150 subuni …
368 results