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Year Number of Results
1984 2
1985 2
1987 1
1988 5
1989 1
1990 5
1991 6
1992 9
1993 9
1994 18
1995 12
1996 22
1997 19
1998 32
1999 31
2000 50
2001 37
2002 88
2003 99
2004 126
2005 119
2006 179
2007 210
2008 266
2009 336
2010 310
2011 394
2012 434
2013 597
2014 929
2015 1150
2016 1122
2017 1202
2018 1438
2019 1738
2020 2013
2021 2348
2022 2682
2023 2868
2024 2571
2025 3

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21,128 results

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Page 1
Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts.
Jin J, Gao L, Zou X, Zhang Y, Zheng Z, Zhang X, Li J, Tian Z, Wang X, Gu J, Zhang C, Wu T, Wang Z, Zhang Q. Jin J, et al. Among authors: zhang c, zhang q, zhang x, zhang y. Circ Res. 2022 Sep 2;131(6):492-506. doi: 10.1161/CIRCRESAHA.122.320771. Epub 2022 Aug 11. Circ Res. 2022. PMID: 35950704 Free article.
Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity.
Zhao C, Ma Y, Zhang M, Gao X, Liang W, Qin Y, Fu Y, Jia M, Song H, Gao C, Zhao W. Zhao C, et al. Among authors: zhang m. Immunity. 2023 Nov 14;56(11):2508-2522.e6. doi: 10.1016/j.immuni.2023.09.012. Epub 2023 Oct 16. Immunity. 2023. PMID: 37848037
Mechanistically, spermine and spermidine induced the transition of B-form DNA to Z-form DNA (Z-DNA), thereby decreasing its binding affinity with cGAS. Spermidine/spermine N1-acetyltransferase 1 (SAT1), the rate-limiting enzyme in polyamine catabolism that decreases …
Mechanistically, spermine and spermidine induced the transition of B-form DNA to Z-form DNA (Z-DNA), thereby decreasing its bi …
Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis.
Yang T, Wang G, Zhang M, Hu X, Li Q, Yun F, Xing Y, Song X, Zhang H, Hu G, Qian Y. Yang T, et al. Among authors: zhang m, zhang h. Cell Rep. 2023 Nov 28;42(11):113377. doi: 10.1016/j.celrep.2023.113377. Epub 2023 Nov 3. Cell Rep. 2023. PMID: 37922310 Free article.
However, it remains unknown how the host-derived Z-RNAs are formed and how these endogenous Z-RNAs are sensed by ZBP1. Here, we report that oxidative stress strongly induces host cell endogenous Z-RNAs, and the Z-RNAs then localize to stress granules f …
However, it remains unknown how the host-derived Z-RNAs are formed and how these endogenous Z-RNAs are sensed by ZBP1. Here, w …
Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis.
Koehler H, Cotsmire S, Zhang T, Balachandran S, Upton JW, Langland J, Kalman D, Jacobs BL, Mocarski ES. Koehler H, et al. Among authors: zhang t. Cell Host Microbe. 2021 Aug 11;29(8):1266-1276.e5. doi: 10.1016/j.chom.2021.05.009. Epub 2021 Jun 29. Cell Host Microbe. 2021. PMID: 34192517 Free PMC article.
Necroptosis mediated by Z-nucleic-acid-binding protein (ZBP)1 (also called DAI or DLM1) contributes to innate host defense against viruses by triggering cell death to eliminate infected cells. During infection, vaccinia virus (VACV) protein E3 prevents death signaling by c …
Necroptosis mediated by Z-nucleic-acid-binding protein (ZBP)1 (also called DAI or DLM1) contributes to innate host defense against vi …
Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1.
Huang L, Wang Y, Long H, Zhu H, Wen Z, Zhang L, Zhang W, Guo Z, Wang L, Tang F, Hu J, Bao K, Zhu P, Li G, Zhou Z. Huang L, et al. Among authors: zhang l, zhang w. Mol Cell. 2023 Aug 17;83(16):2884-2895.e7. doi: 10.1016/j.molcel.2023.07.001. Epub 2023 Aug 2. Mol Cell. 2023. PMID: 37536340 Free article.
DNA replication ensures the accurate transmission of genetic information during the cell cycle. Histone variant H2A.Z is crucial for early replication origins licensing and activation in which SUV420H1 preferentially recognizes H2A.Z-nucleosome and deposits H4 lysin …
DNA replication ensures the accurate transmission of genetic information during the cell cycle. Histone variant H2A.Z is crucial for …
Detecting Z-RNA and Z-DNA in Mammalian Cells.
Yin C, Zhang T, Balachandran S. Yin C, et al. Among authors: zhang t. Methods Mol Biol. 2023;2651:277-284. doi: 10.1007/978-1-0716-3084-6_19. Methods Mol Biol. 2023. PMID: 36892774
Z-RNA is detected by Zalpha domain containing PRRs, including Z-form nucleic acid binding protein 1 (ZBP1) and the p150 subunit of adenosine deaminase RNA specific 1 (ADAR1). ...In this chapter, we describe our procedure for detecting Z-RNA in influenza A vir …
Z-RNA is detected by Zalpha domain containing PRRs, including Z-form nucleic acid binding protein 1 (ZBP1) and the p150 subuni …
Isoliquiritigenin suppresses the progression of malignant melanoma via targeting H2A.Z.1-E2F1 pathway.
Xiang S, Jian L, Zeng H, Wu H, Ge B, Zhang P, Lin J, Guo A, Zhou B. Xiang S, et al. Among authors: zhang p. Biochem Pharmacol. 2023 Dec;218:115859. doi: 10.1016/j.bcp.2023.115859. Epub 2023 Oct 18. Biochem Pharmacol. 2023. PMID: 37863326 Free article.
In this study, differentiallyexpressedproteins were identified bylabel-free quantitative mass spectrometry. Two isoforms of the histone variant H2A.Z, including H2A.Z.1 and H2A.Z.2, were significantly down regulated after administration of ISL in melanoma. .. …
In this study, differentiallyexpressedproteins were identified bylabel-free quantitative mass spectrometry. Two isoforms of the histone vari …
Manipulating Radiation-Sensitive Z-DNA Conformation for Enhanced Radiotherapy.
Wang D, Liao Y, Zeng H, Gu C, Wang X, Zhu S, Guo X, Zhang J, Zheng Z, Yan J, Zhang F, Hou L, Gu Z, Sun B. Wang D, et al. Among authors: zhang f, zhang j. Adv Mater. 2024 Jul;36(29):e2313991. doi: 10.1002/adma.202313991. Epub 2024 May 9. Adv Mater. 2024. PMID: 38692575
Thereout, a radiosensitization strategy focused on inducing Z-DNA conformation, utilizing CBL@HfO(2) nanocapsules loaded with a Z-DNA inducer CBL0137, is proposed. ...The approach enables DSBs augmentation by improving the inherent radiosensitivity of DNA. As such, …
Thereout, a radiosensitization strategy focused on inducing Z-DNA conformation, utilizing CBL@HfO(2) nanocapsules loaded with a Z …
Characterization of Z-DNA by Infrared Spectroscopy.
Zhang F, Huang Q. Zhang F, et al. Methods Mol Biol. 2023;2651:53-58. doi: 10.1007/978-1-0716-3084-6_3. Methods Mol Biol. 2023. PMID: 36892758
Here we describe the method of application of infrared spectroscopy in the investigation of Z-DNA in cells, as infrared spectroscopy can distinguish DNA secondary structures sensitively and the band at 930 cm(-1) is specifically attributed to the Z-form DNA. Based o …
Here we describe the method of application of infrared spectroscopy in the investigation of Z-DNA in cells, as infrared spectroscopy …
Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1.
Wang Z, Zhang D, Qiu X, Inuzuka H, Xiong Y, Liu J, Chen L, Chen H, Xie L, Kaniskan HÜ, Chen X, Jin J, Wei W. Wang Z, et al. Among authors: zhang d. J Am Chem Soc. 2024 Mar 20;146(11):7584-7593. doi: 10.1021/jacs.3c13646. Epub 2024 Mar 12. J Am Chem Soc. 2024. PMID: 38469801 Free PMC article.
The core of our innovation lies in the strategic engagement of Z-form DNA with ADAR1 and its degradation is achieved by leveraging a VHL ligand conjugated to Z-form DNA to recruit the E3 ligase. ...In summary, the Z-DNA-based PROTAC (Z-PROTAC) approach …
The core of our innovation lies in the strategic engagement of Z-form DNA with ADAR1 and its degradation is achieved by leveraging a …
21,128 results
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