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83 results

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Page 1
Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer.
Sharma S, Chung CY, Uryu S, Petrovic J, Cao J, Rickard A, Nady N, Greasley S, Johnson E, Brodsky O, Khan S, Wang H, Wang Z, Zhang Y, Tsaparikos K, Chen L, Mazurek A, Lapek J, Kung PP, Sutton S, Richardson PF, Greenwald EC, Yamazaki S, Jones R, Maegley KA, Bingham P, Lam H, Stupple AE, Kamal A, Chueh A, Cuzzupe A, Morrow BJ, Ren B, Carrasco-Pozo C, Tan CW, Bhuva DD, Allan E, Surgenor E, Vaillant F, Pehlivanoglu H, Falk H, Whittle JR, Newman J, Cursons J, Doherty JP, White KL, MacPherson L, Devlin M, Dennis ML, Hattarki MK, De Silva M, Camerino MA, Butler MS, Dolezal O, Pilling P, Foitzik R, Stupple PA, Lagiakos HR, Walker SR, Hediyeh-Zadeh S, Nuttall S, Spall SK, Charman SA, Connor T, Peat TS, Avery VM, Bozikis YE, Yang Y, Zhang M, Monahan BJ, Voss AK, Thomas T, Street IP, Dawson SJ, Dawson MA, Lindeman GJ, Davis MJ, Visvader JE, Paul TA. Sharma S, et al. Cell Chem Biol. 2023 Oct 19;30(10):1191-1210.e20. doi: 10.1016/j.chembiol.2023.07.005. Epub 2023 Aug 8. Cell Chem Biol. 2023. PMID: 37557181 Free article.
Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels.
Murray A, Gough G, Cindrić A, Vučković F, Koschut D, Borelli V, Petrović DJ, Bekavac A, Plećaš A, Hribljan V, Brunmeir R, Jurić J, Pučić-Baković M, Slana A, Deriš H, Frkatović A, Groet J, O'Brien NL, Chen HY, Yeap YJ, Delom F, Havlicek S, Gammon L, Hamburg S, Startin C, D'Souza H, Mitrečić D, Kero M, Odak L, Krušlin B, Krsnik Ž, Kostović I, Foo JN, Loh YH, Dunn NR, de la Luna S, Spector T, Barišić I, Thomas MSC, Strydom A, Franceschi C, Lauc G, Krištić J, Alić I, Nižetić D. Murray A, et al. EBioMedicine. 2023 Aug;94:104692. doi: 10.1016/j.ebiom.2023.104692. Epub 2023 Jul 12. EBioMedicine. 2023. PMID: 37451904 Free PMC article.
FUNDING: Main funding came from the "Research Cooperability" Program of the Croatian Science Foundation funded by the European Union from the European Social Fund under the Operational Programme Efficient Human Resources 2014-2020, Project PZS-2019-02-4277, and the Wellcome Trust …
FUNDING: Main funding came from the "Research Cooperability" Program of the Croatian Science Foundation funded by the European Union from th …
Therapeutic dilemmas with benzodiazepines and Z-drugs: insomnia and anxiety disorders versus increased fall risk: a clinical review.
Capiau A, Huys L, van Poelgeest E, van der Velde N, Petrovic M, Somers A; EuGMS Task, Finish Group on FRIDs. Capiau A, et al. Eur Geriatr Med. 2023 Aug;14(4):697-708. doi: 10.1007/s41999-022-00731-4. Epub 2022 Dec 28. Eur Geriatr Med. 2023. PMID: 36576689 Free PMC article. Review.
We discuss use of BZDs and Z-drugs, potential fall-related adverse reactions, alternatives for and deprescribing of BZDs and Z-drugs in older persons. ...Practical resources, tools and algorithms are available to guide and assist clinicians in deprescribing BZDs and …
We discuss use of BZDs and Z-drugs, potential fall-related adverse reactions, alternatives for and deprescribing of BZDs and Z …
A prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
NIHR Global Health Research Unit on Global Surgery; STARSurg Collaborative. NIHR Global Health Research Unit on Global Surgery, et al. Lancet Digit Health. 2024 Jul;6(7):e507-e519. doi: 10.1016/S2589-7500(24)00065-7. Lancet Digit Health. 2024. PMID: 38906616 Free PMC article.
A multi-country analysis of COVID-19 hospitalizations by vaccination status.
Gonçalves BP, Jassat W, Baruch J, Hashmi M, Rojek A, Dasgupta A, Martin-Loeches I, Reyes LF, Piubelli C, Citarella BW, Kartsonaki C, Lefèvre B, López Revilla JW, Lunn M, Harrison EM, Kraemer MUG, Shrapnel S, Horby P, Bisoffi Z, Olliaro PL, Merson L; ISARIC Clinical Characterisation Group. Gonçalves BP, et al. Med. 2023 Nov 10;4(11):797-812.e2. doi: 10.1016/j.medj.2023.08.005. Epub 2023 Sep 21. Med. 2023. PMID: 37738979 Free PMC article.
FUNDING: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); …
FUNDING: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 22241 …
Z-DNA Hunter tool for straightforward detection of Z-DNA forming regions and a case study in Drosophila.
Petrovič M, Bartas M, Garratt AN, Pečinka P, Dobrovolná M, Koňaříková K, Trenz O, Brázda V, Šťastný J. Petrovič M, et al. NAR Genom Bioinform. 2025 Nov 21;7(4):lqaf166. doi: 10.1093/nargab/lqaf166. eCollection 2025 Dec. NAR Genom Bioinform. 2025. PMID: 41278536 Free PMC article.
Z-DNA is a left-handed DNA conformation linked to gene regulation, chromatin dynamics, and immunity. Despite its importance, genome-wide prediction of Z-DNA forming sequences (ZFS) remains limited by the absence of fast and accessible tools. ...
Z-DNA is a left-handed DNA conformation linked to gene regulation, chromatin dynamics, and immunity. Despite its importance, genome-w …
Enhanced Sweat Biosensing with Thread-Embedded Microfluidic Devices.
Joseph K, Ibrahim F, Qureshi S, Petrović B, Kojić S, Thiha A, Jamaluddin N, Dahlan N, Stojanović G. Joseph K, et al. Med Sci Monit. 2024 Jun 12;30:e943321. doi: 10.12659/MSM.943321. Med Sci Monit. 2024. PMID: 38863180 Free PMC article.
Impedance analysis using HIOKI IM3590 was conducted for saline and artificial sweat solutions on 4 identical CDs, ensuring reliable conductivity and measurements over a 1 kHz to 200 kHz frequency range. RESULTS Significant differences in |Z| values were observed between sa …
Impedance analysis using HIOKI IM3590 was conducted for saline and artificial sweat solutions on 4 identical CDs, ensuring reliable conducti …
A systematic review of interventions to deprescribe benzodiazepines and other hypnotics among older people.
Reeve E, Ong M, Wu A, Jansen J, Petrovic M, Gnjidic D. Reeve E, et al. Eur J Clin Pharmacol. 2017 Aug;73(8):927-935. doi: 10.1007/s00228-017-2257-8. Epub 2017 Apr 30. Eur J Clin Pharmacol. 2017. PMID: 28456823
The aim of this systematic review was to critically evaluate the success of interventions used to reduce benzodiazepines and 'Z-drug' use, and the impact of these interventions on clinical outcomes in older adults. ...RESULTS: Seven studies of benzodiazepines and Z- …
The aim of this systematic review was to critically evaluate the success of interventions used to reduce benzodiazepines and 'Z-drug' …
Hearing aid use and gender differences in the auditory-cognitive cascade in the oldest old.
Vella Azzopardi R, Beyer I, De Raedemaeker K, Foulon I, Vermeiren S, Petrovic M, Van Den Noortgate N, Bautmans I, Gorus E; Gerontopole Brussels Study group. Vella Azzopardi R, et al. Aging Ment Health. 2023 Jan;27(1):184-192. doi: 10.1080/13607863.2021.2007355. Epub 2021 Dec 23. Aging Ment Health. 2023. PMID: 34937465
Pearson and partial correlations (correcting for age and PTA) assessed auditory-cognitive associations within gender and HA subgroups. Fisher's z test compared correlations between HA and non-HA users. RESULTS: 126 participants (age range 80-91 years) were included. ...Sig …
Pearson and partial correlations (correcting for age and PTA) assessed auditory-cognitive associations within gender and HA subgroups. Fishe …
83 results