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248 results

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Page 1
ZBTB20 Regulates SERCA2a Activity and Myocardial Contractility Through Phospholamban.
Ren AJ, Wei C, Liu YJ, Liu M, Wang P, Fan J, Wang K, Zhang S, Qin Z, Ren QX, Zheng Y, Chen YX, Xie Z, Gao L, Zhu Y, Zhang Y, Yang HT, Zhang WJ. Ren AJ, et al. Circ Res. 2024 Feb 2;134(3):252-265. doi: 10.1161/CIRCRESAHA.123.323798. Epub 2024 Jan 3. Circ Res. 2024. PMID: 38166470 Free article.
Mechanistically, PLN expression was dramatically reduced in cardiomyocytes at the mRNA and protein levels by ZBTB20 deletion or silencing, and PLN overexpression could largely restore the basal contractility in ZBTB20-deficient cardiomyocytes. CONCLUSIONS: These dat …
Mechanistically, PLN expression was dramatically reduced in cardiomyocytes at the mRNA and protein levels by ZBTB20 deletion or silen …
LATS1-modulated ZBTB20 perturbing cartilage matrix homeostasis contributes to early-stage osteoarthritis.
Hao X, Zhao J, Jia L, Ding G, Liang X, Su F, Yang S, Yang Y, Fan J, Zhang WJ, Yang L, Jie Q. Hao X, et al. Bone Res. 2025 Mar 12;13(1):33. doi: 10.1038/s41413-025-00414-3. Bone Res. 2025. PMID: 40069162 Free PMC article.
The NF-kappaB signaling mediated disturbance of ECM maintenance by ZBTB20 requires its suppression of Pten and consequent PI3K-Akt signaling activation. Furthermore, the subcellular localization of ZBTB20 was modulated by the kinase LATS1. ...The compounds TRULI and …
The NF-kappaB signaling mediated disturbance of ECM maintenance by ZBTB20 requires its suppression of Pten and consequent PI3K-Akt si …
ZBTB20 is essential for cochlear maturation and hearing in mice.
Xie Z, Ma XH, Bai QF, Tang J, Sun JH, Jiang F, Guo W, Wang CM, Yang R, Wen YC, Wang FY, Chen YX, Zhang H, He DZ, Kelley MW, Yang S, Zhang WJ. Xie Z, et al. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120. doi: 10.1073/pnas.2220867120. Epub 2023 Jun 6. Proc Natl Acad Sci U S A. 2023. PMID: 37279265 Free PMC article.
ZBTB20 is abundantly expressed in the developing and mature cochlear nonsensory epithelial cells, with transient expression in immature hair cells and spiral ganglion neurons. ...Our results point to ZBTB20 as an essential regulator for postnatal cochlear maturation …
ZBTB20 is abundantly expressed in the developing and mature cochlear nonsensory epithelial cells, with transient expression in immatu …
Transcription Factor Zbtb20 as a Regulator of Malignancy and Its Practical Applications.
Stoyanov D, Stoyanov GS, Ivanov MN, Spasov RH, Tonchev AB. Stoyanov D, et al. Int J Mol Sci. 2023 Sep 6;24(18):13763. doi: 10.3390/ijms241813763. Int J Mol Sci. 2023. PMID: 37762065 Free PMC article. Review.
Zbtb20 (zinc finger and BTB domain-containing protein 20) is a transcription factor with a zinc finger DNA binding domain and a BTB domain responsible for protein-protein interaction. ...Here we review the current data connecting Zbtb20 with malignant tumors....
Zbtb20 (zinc finger and BTB domain-containing protein 20) is a transcription factor with a zinc finger DNA binding domain and a BTB d …
ZBTB20 Regulates Prolactin Expression and Lactotrope Function in Adult Mice.
Han Q, Yan X, Ye Y, Han L, Ma X, Wang T, Cao D, Zhang WJ. Han Q, et al. Endocrinology. 2022 Oct 23;163(12):bqac181. doi: 10.1210/endocr/bqac181. Endocrinology. 2022. PMID: 36288554
However, the potential role of ZBTB20 in mature lactotropes remains unclear. Here we demonstrate that ZBTB20 acts as a critical cell-autonomous regulator for PRL expression in mature lactotropes in adult mice. ...Thus, our data point to an important role of ZBTB2 …
However, the potential role of ZBTB20 in mature lactotropes remains unclear. Here we demonstrate that ZBTB20 acts as a critica …
ZBTB20-AS1 promoted Alzheimer's disease progression through ZBTB20/GSK-3beta/Tau pathway.
Wang Y, Cai M, Lou Y, Zhang S, Liu X. Wang Y, et al. Biochem Biophys Res Commun. 2023 Jan 15;640:88-96. doi: 10.1016/j.bbrc.2022.11.107. Epub 2022 Dec 1. Biochem Biophys Res Commun. 2023. PMID: 36502636
The results showed that expression of LncRNA ZBTB20-AS1 was significantly upregulated, while ZBTB20 was downregulated in SH-SY5Y-AD cells. ZBTB20 was the target gene of LncRNA ZBTB20-AS1. Overexpression of ZBTB20 or knockdown of LncRNA ZBTB20 …
The results showed that expression of LncRNA ZBTB20-AS1 was significantly upregulated, while ZBTB20 was downregulated in SH-SY …
ZBTB20 suppresses tumor growth in glioblastoma through activating the TET1/FAS/caspase-3 pathway.
Duan P, Li B, Zhou Y, Cao H, Chen S, Xing Y. Duan P, et al. Oncol Lett. 2024 Jun 5;28(2):358. doi: 10.3892/ol.2024.14491. eCollection 2024 Aug. Oncol Lett. 2024. PMID: 38881713 Free PMC article.
The results demonstrated that ZBTB20 overexpression decreased GBM cell proliferation, while ZBTB20 knockdown significantly enhanced it. Cell cycle analysis showed the ZBTB20 overexpression may have inhibited proliferation through cell cycle arrest at the G2/M …
The results demonstrated that ZBTB20 overexpression decreased GBM cell proliferation, while ZBTB20 knockdown significantly enh …
Zbtb20 deficiency causes cardiac contractile dysfunction in mice.
Ren AJ, Chen C, Zhang S, Liu M, Wei C, Wang K, Ma X, Song Y, Wang R, Zhang H, Chen YX, Wu H, Xie Z, Zhang Y, Zhang WJ. Ren AJ, et al. FASEB J. 2020 Oct;34(10):13862-13876. doi: 10.1096/fj.202000160RR. Epub 2020 Aug 26. FASEB J. 2020. PMID: 32844471
The zinc-finger protein ZBTB20 regulates development and metabolism in multiple systems, and is essential for postnatal survival in mice. ...Notably, echocardiographic and hemodynamic analyses showed that cardiac contractility was greatly impaired in the absence of ZBTB …
The zinc-finger protein ZBTB20 regulates development and metabolism in multiple systems, and is essential for postnatal survival in m …
ZBTB20 Regulating Postnatal Articular Cartilage Development and Homeostasis: Implications for Early-Onset Osteoarthritis.
Ma X, Jiang F, Qin Z, Zhang Y, Wei C, Han S, Chen Y, Zhang H, Tao J, Xie Z, Zhang WJ. Ma X, et al. Arthritis Rheumatol. 2025 Sep 15. doi: 10.1002/art.43393. Online ahead of print. Arthritis Rheumatol. 2025. PMID: 40948117
METHODS: We assessed the spatiotemporal expression of ZBTB20 in articular cartilage using immunostaining and generated an inducible cartilage-specific Zbtb20 knockout mouse model. ...Moreover, ZBTB20 expression was significantly reduced in aging-related OA ca …
METHODS: We assessed the spatiotemporal expression of ZBTB20 in articular cartilage using immunostaining and generated an inducible c …
Dysfunctional microRNA-144-3p/ZBTB20/ERK/CREB1 signalling pathway is associated with MK-801-induced schizophrenia-like abnormalities.
Pan B, Han B, Zhu X, Wang Y, Ji H, Weng J, Liu Y. Pan B, et al. Brain Res. 2023 Jan 1;1798:148153. doi: 10.1016/j.brainres.2022.148153. Epub 2022 Nov 4. Brain Res. 2023. PMID: 36335997
The RNA-Seq test revealed that ZBTB20 was altered in the model rat HIP. Further experiments confirmed the reduced ZBTB20 mRNA and protein levels in the model rat HIP and caudate putamen (CPu), accompanied by increased miR-144-3p levels. Moreover, the ZBTB20 e …
The RNA-Seq test revealed that ZBTB20 was altered in the model rat HIP. Further experiments confirmed the reduced ZBTB20 mRNA …
248 results