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ZEB1 protects skeletal muscle from damage and is required for its regeneration.
Siles L, Ninfali C, Cortés M, Darling DS, Postigo A. Siles L, et al. Nat Commun. 2019 Mar 25;10(1):1364. doi: 10.1038/s41467-019-08983-8. Nat Commun. 2019. PMID: 30910999 Free PMC article.
Macrophages in Zeb1-deficient injured muscles show lower phosphorylation of p38 and its forced activation reverts the enhanced muscle damage and poorer regeneration. ...These data indicate that ZEB1 protects muscle from damage and is required for its r …
Macrophages in Zeb1-deficient injured muscles show lower phosphorylation of p38 and its forced activation reverts the enhanced mus
Regulation of muscle atrophy-related genes by the opposing transcriptional activities of ZEB1/CtBP and FOXO3.
Ninfali C, Siles L, Darling DS, Postigo A. Ninfali C, et al. Nucleic Acids Res. 2018 Nov 16;46(20):10697-10708. doi: 10.1093/nar/gky835. Nucleic Acids Res. 2018. PMID: 30304480 Free PMC article.
ZEB1 bound to the Fbxo32 promoter in undifferentiated myoblasts and atrophic myotubes, but not in non-atrophic myotubes, where it is displaced by MYOD1. ...These results set ZEB1 as a new target in therapeutic approaches to clinical conditions causing musc
ZEB1 bound to the Fbxo32 promoter in undifferentiated myoblasts and atrophic myotubes, but not in non-atrophic myotubes, where
miRNA-223 upregulated by MYOD inhibits myoblast proliferation by repressing IGF2 and facilitates myoblast differentiation by inhibiting ZEB1.
Li G, Luo W, Abdalla BA, Ouyang H, Yu J, Hu F, Nie Q, Zhang X. Li G, et al. Cell Death Dis. 2017 Oct 5;8(10):e3094. doi: 10.1038/cddis.2017.479. Cell Death Dis. 2017. PMID: 28981085 Free PMC article.
Skeletal muscle differentiation can be regulated by various transcription factors and non-coding RNAs. ...The target inhibition of miR-223 on IGF2 and ZEB1 are dynamic from proliferation to differentiation of myoblast. miR-223 inhibits IGF2 expression
Skeletal muscle differentiation can be regulated by various transcription factors and non-coding RNAs. ...The target inhibitio
ZEB1 imposes a temporary stage-dependent inhibition of muscle gene expression and differentiation via CtBP-mediated transcriptional repression.
Siles L, Sánchez-Tilló E, Lim JW, Darling DS, Kroll KL, Postigo A. Siles L, et al. Mol Cell Biol. 2013 Apr;33(7):1368-82. doi: 10.1128/MCB.01259-12. Epub 2013 Jan 22. Mol Cell Biol. 2013. PMID: 23339872 Free PMC article.
Skeletal muscle development is orchestrated by the myogenic regulatory factor MyoD, whose activity is blocked in myoblasts by proteins preventing its nuclear translocation and/or binding to G/C-centered E-boxes in target genes. ...We found that, contrary to M
Skeletal muscle development is orchestrated by the myogenic regulatory factor MyoD, whose activity is blocked in myoblasts
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