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How honey kills bacteria.
Kwakman PH, te Velde AA, de Boer L, Speijer D, Vandenbroucke-Grauls CM, Zaat SA. Kwakman PH, et al. Among authors: zaat sa. FASEB J. 2010 Jul;24(7):2576-82. doi: 10.1096/fj.09-150789. Epub 2010 Mar 12. FASEB J. 2010. PMID: 20228250
Treatment and prevention of Staphylococcus epidermidis experimental biomaterial-associated infection by bactericidal peptide 2.
Kwakman PH, te Velde AA, Vandenbroucke-Grauls CM, van Deventer SJ, Zaat SA. Kwakman PH, et al. Among authors: zaat sa. Antimicrob Agents Chemother. 2006 Dec;50(12):3977-83. doi: 10.1128/AAC.00575-06. Epub 2006 Sep 25. Antimicrob Agents Chemother. 2006. PMID: 17000746 Free PMC article.
Staphylococcus epidermidis is cleared from biomaterial implants but persists in peri-implant tissue in mice despite rifampicin/vancomycin treatment.
Broekhuizen CA, de Boer L, Schipper K, Jones CD, Quadir S, Vandenbroucke-Grauls CM, Zaat SA. Broekhuizen CA, et al. Among authors: zaat sa. J Biomed Mater Res A. 2008 May;85(2):498-505. doi: 10.1002/jbm.a.31528. J Biomed Mater Res A. 2008. PMID: 17729261
Medical-grade honey kills antibiotic-resistant bacteria in vitro and eradicates skin colonization.
Kwakman PH, Van den Akker JP, Güçlü A, Aslami H, Binnekade JM, de Boer L, Boszhard L, Paulus F, Middelhoek P, te Velde AA, Vandenbroucke-Grauls CM, Schultz MJ, Zaat SA. Kwakman PH, et al. Among authors: zaat sa. Clin Infect Dis. 2008 Jun 1;46(11):1677-82. doi: 10.1086/587892. Clin Infect Dis. 2008. PMID: 18433338
Tissue around catheters is a niche for bacteria associated with medical device infection.
Broekhuizen CA, Schultz MJ, van der Wal AC, Boszhard L, de Boer L, Vandenbroucke-Grauls CM, Zaat SA. Broekhuizen CA, et al. Among authors: zaat sa. Crit Care Med. 2008 Aug;36(8):2395-402. doi: 10.1097/CCM.0b013e3181818268. Crit Care Med. 2008. PMID: 18664789
Two major medicinal honeys have different mechanisms of bactericidal activity.
Kwakman PH, Te Velde AA, de Boer L, Vandenbroucke-Grauls CM, Zaat SA. Kwakman PH, et al. Among authors: zaat sa. PLoS One. 2011 Mar 4;6(3):e17709. doi: 10.1371/journal.pone.0017709. PLoS One. 2011. PMID: 21394213 Free PMC article.
Native thrombocidin-1 and unfolded thrombocidin-1 exert antimicrobial activity via distinct structural elements.
Kwakman PH, Krijgsveld J, de Boer L, Nguyen LT, Boszhard L, Vreede J, Dekker HL, Speijer D, Drijfhout JW, te Velde AA, Crielaard W, Vogel HJ, Vandenbroucke-Grauls CM, Zaat SA. Kwakman PH, et al. Among authors: zaat sa. J Biol Chem. 2011 Dec 16;286(50):43506-14. doi: 10.1074/jbc.M111.248641. Epub 2011 Oct 24. J Biol Chem. 2011. PMID: 22025617 Free PMC article.
Antibacterial components of honey.
Kwakman PH, Zaat SA. Kwakman PH, et al. Among authors: zaat sa. IUBMB Life. 2012 Jan;64(1):48-55. doi: 10.1002/iub.578. Epub 2011 Nov 17. IUBMB Life. 2012. PMID: 22095907
Antibiotic prophylaxis in (sub)normothermic organ preservation: in vitro efficacy and toxicity of cephalosporins.
Bruinsma BG, Post IC, van Rijssen LB, de Boer L, Heger M, Zaat SA, van Gulik TM. Bruinsma BG, et al. Among authors: zaat sa. Transplantation. 2013 Apr 27;95(8):1064-9. doi: 10.1097/TP.0b013e318284c17a. Transplantation. 2013. PMID: 23411744
A doxycycline-loaded polymer-lipid encapsulation matrix coating for the prevention of implant-related osteomyelitis due to doxycycline-resistant methicillin-resistant Staphylococcus aureus.
Metsemakers WJ, Emanuel N, Cohen O, Reichart M, Potapova I, Schmid T, Segal D, Riool M, Kwakman PH, de Boer L, de Breij A, Nibbering PH, Richards RG, Zaat SA, Moriarty TF. Metsemakers WJ, et al. Among authors: zaat sa. J Control Release. 2015 Jul 10;209:47-56. doi: 10.1016/j.jconrel.2015.04.022. Epub 2015 Apr 21. J Control Release. 2015. PMID: 25910578
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