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The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.
Vu LP, Pickering BF, Cheng Y, Zaccara S, Nguyen D, Minuesa G, Chou T, Chow A, Saletore Y, MacKay M, Schulman J, Famulare C, Patel M, Klimek VM, Garrett-Bakelman FE, Melnick A, Carroll M, Mason CE, Jaffrey SR, Kharas MG. Vu LP, et al. Among authors: zaccara s. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18. Nat Med. 2017. PMID: 28920958 Free PMC article.
m6A enhances the phase separation potential of mRNA.
Ries RJ, Zaccara S, Klein P, Olarerin-George A, Namkoong S, Pickering BF, Patil DP, Kwak H, Lee JH, Jaffrey SR. Ries RJ, et al. Among authors: zaccara s. Nature. 2019 Jul;571(7765):424-428. doi: 10.1038/s41586-019-1374-1. Epub 2019 Jul 10. Nature. 2019. PMID: 31292544 Free PMC article.
Live imaging of mRNA using RNA-stabilized fluorogenic proteins.
Wu J, Zaccara S, Khuperkar D, Kim H, Tanenbaum ME, Jaffrey SR. Wu J, et al. Among authors: zaccara s. Nat Methods. 2019 Sep;16(9):862-865. doi: 10.1038/s41592-019-0531-7. Epub 2019 Aug 30. Nat Methods. 2019. PMID: 31471614 Free PMC article.
Reading, writing and erasing mRNA methylation.
Zaccara S, Ries RJ, Jaffrey SR. Zaccara S, et al. Nat Rev Mol Cell Biol. 2019 Oct;20(10):608-624. doi: 10.1038/s41580-019-0168-5. Epub 2019 Sep 13. Nat Rev Mol Cell Biol. 2019. PMID: 31520073 Review.
Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6-Methyladenosine-Modified RNAs.
Micaelli M, Dalle Vedove A, Cerofolini L, Vigna J, Sighel D, Zaccara S, Bonomo I, Poulentzas G, Rosatti EF, Cazzanelli G, Alunno L, Belli R, Peroni D, Dassi E, Murakami S, Jaffrey SR, Fragai M, Mancini I, Lolli G, Quattrone A, Provenzani A. Micaelli M, et al. Among authors: zaccara s. ACS Pharmacol Transl Sci. 2022 Sep 14;5(10):872-891. doi: 10.1021/acsptsci.2c00008. eCollection 2022 Oct 14. ACS Pharmacol Transl Sci. 2022. PMID: 36268123 Free PMC article.
Translation control can shape TP53-dependent cell fate.
Rizzotto D, Zaccara S, Rossi A, Dassi E, Inga A. Rizzotto D, et al. Among authors: zaccara s. Mol Cell Oncol. 2020 Jun 23;7(5):1767483. doi: 10.1080/23723556.2020.1767483. eCollection 2020. Mol Cell Oncol. 2020. PMID: 32944629 Free PMC article.
32 results