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VEGF 165 b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy.
Varey AH, Rennel ES, Qiu Y, Bevan HS, Perrin RM, Raffy S, Dixon AR, Paraskeva C, Zaccheo O, Hassan AB, Harper SJ, Bates DO. Varey AH, et al. Among authors: zaccheo o. Br J Cancer. 2008 Apr 22;98(8):1366-79. doi: 10.1038/sj.bjc.6604308. Epub 2008 Mar 18. Br J Cancer. 2008. PMID: 18349829 Free PMC article.
Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.
Frago S, Nicholls RD, Strickland M, Hughes J, Williams C, Garner L, Surakhy M, Maclean R, Rezgui D, Prince SN, Zaccheo OJ, Ebner D, Sanegre S, Yu S, Buffa FM, Crump MP, Hassan AB. Frago S, et al. Among authors: zaccheo oj. Proc Natl Acad Sci U S A. 2016 May 17;113(20):E2766-75. doi: 10.1073/pnas.1513023113. Epub 2016 May 2. Proc Natl Acad Sci U S A. 2016. PMID: 27140600 Free PMC article.
An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Williams C, Hoppe HJ, Rezgui D, Strickland M, Forbes BE, Grutzner F, Frago S, Ellis RZ, Wattana-Amorn P, Prince SN, Zaccheo OJ, Nolan CM, Mungall AJ, Jones EY, Crump MP, Hassan AB. Williams C, et al. Among authors: zaccheo oj. Science. 2012 Nov 30;338(6111):1209-13. doi: 10.1126/science.1228633. Science. 2012. PMID: 23197533 Free PMC article.
Structure and functional analysis of the IGF-II/IGF2R interaction.
Brown J, Delaine C, Zaccheo OJ, Siebold C, Gilbert RJ, van Boxel G, Denley A, Wallace JC, Hassan AB, Forbes BE, Jones EY. Brown J, et al. Among authors: zaccheo oj. EMBO J. 2008 Jan 9;27(1):265-76. doi: 10.1038/sj.emboj.7601938. Epub 2007 Nov 29. EMBO J. 2008. PMID: 18046459 Free PMC article.
Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions.
Rowley TF, Peters SJ, Aylott M, Griffin R, Davies NL, Healy LJ, Cutler RM, Eddleston A, Pither TL, Sopp JM, Zaccheo O, Fossati G, Cain K, Ventom AM, Hailu H, Ward EJ, Sherington J, Brennan FR, Fallah-Arani F, Humphreys DP. Rowley TF, et al. Among authors: zaccheo o. Commun Biol. 2018 Sep 14;1:146. doi: 10.1038/s42003-018-0149-9. eCollection 2018. Commun Biol. 2018. PMID: 30272022 Free PMC article.
14 results