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Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes.
Sin YY, Edwards HV, Li X, Day JP, Christian F, Dunlop AJ, Adams DR, Zaccolo M, Houslay MD, Baillie GS. Sin YY, et al. J Mol Cell Cardiol. 2011 May;50(5):872-83. doi: 10.1016/j.yjmcc.2011.02.006. Epub 2011 Feb 18. J Mol Cell Cardiol. 2011. PMID: 21334344
A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells.
Wilson LS, Baillie GS, Pritchard LM, Umana B, Terrin A, Zaccolo M, Houslay MD, Maurice DH. Wilson LS, et al. J Biol Chem. 2011 May 6;286(18):16285-96. doi: 10.1074/jbc.M110.217026. Epub 2011 Mar 10. J Biol Chem. 2011. PMID: 21393242 Free PMC article.
Improvement of a FRET-based indicator for cAMP by linker design and stabilization of donor-acceptor interaction.
Lissandron V, Terrin A, Collini M, D'alfonso L, Chirico G, Pantano S, Zaccolo M. Lissandron V, et al. J Mol Biol. 2005 Dec 2;354(3):546-55. doi: 10.1016/j.jmb.2005.09.089. Epub 2005 Oct 21. J Mol Biol. 2005. PMID: 16257413
Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.
Miller CL, Cai Y, Oikawa M, Thomas T, Dostmann WR, Zaccolo M, Fujiwara K, Yan C. Miller CL, et al. Basic Res Cardiol. 2011 Nov;106(6):1023-39. doi: 10.1007/s00395-011-0228-2. Epub 2011 Oct 20. Basic Res Cardiol. 2011. PMID: 22012077 Free PMC article.
Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.
Mongillo M, Tocchetti CG, Terrin A, Lissandron V, Cheung YF, Dostmann WR, Pozzan T, Kass DA, Paolocci N, Houslay MD, Zaccolo M. Mongillo M, et al. Circ Res. 2006 Feb 3;98(2):226-34. doi: 10.1161/01.RES.0000200178.34179.93. Epub 2005 Dec 15. Circ Res. 2006. PMID: 16357307
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