Abstract
A new method has been used to measure tissue levels of amiodarone and its major metabolite desethylamiodarone. Amiodarone-pigmented skin has a drug and metabolite concentration ten times that of non-pigmented skin. Iodine-rich amiodarone and its metabolite have been detected in secondary lysosomes by energy dispersive analysis of X-rays. Amiodarone induces a phototoxic reaction with an action spectrum in both the UV-B and UV-A wavelengths.
MeSH terms
-
Adult
-
Amiodarone / adverse effects*
-
Amiodarone / analogs & derivatives
-
Amiodarone / metabolism
-
Benzofurans / adverse effects*
-
Chromatography, High Pressure Liquid
-
Electron Probe Microanalysis
-
Humans
-
Male
-
Microscopy, Electron
-
Middle Aged
-
Photosensitivity Disorders / chemically induced*
-
Photosensitivity Disorders / metabolism
-
Photosensitivity Disorders / pathology
-
Skin / metabolism
-
Skin / pathology
-
Skin Pigmentation*
Substances
-
Benzofurans
-
desethylamiodarone
-
Amiodarone