The pathogenesis of amiodarone-induced pigmentation and photosensitivity

Br J Dermatol. 1984 Apr;110(4):451-6. doi: 10.1111/j.1365-2133.1984.tb04660.x.

Abstract

A new method has been used to measure tissue levels of amiodarone and its major metabolite desethylamiodarone. Amiodarone-pigmented skin has a drug and metabolite concentration ten times that of non-pigmented skin. Iodine-rich amiodarone and its metabolite have been detected in secondary lysosomes by energy dispersive analysis of X-rays. Amiodarone induces a phototoxic reaction with an action spectrum in both the UV-B and UV-A wavelengths.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amiodarone / adverse effects*
  • Amiodarone / analogs & derivatives
  • Amiodarone / metabolism
  • Benzofurans / adverse effects*
  • Chromatography, High Pressure Liquid
  • Electron Probe Microanalysis
  • Humans
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Photosensitivity Disorders / chemically induced*
  • Photosensitivity Disorders / metabolism
  • Photosensitivity Disorders / pathology
  • Skin / metabolism
  • Skin / pathology
  • Skin Pigmentation*

Substances

  • Benzofurans
  • desethylamiodarone
  • Amiodarone