Zahler R - Search Results

1

Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells.

Manne V, Yan N, Carboni JM, Tuomari AV, Ricca CS, Brown JG, Andahazy ML, Schmidt RJ, Patel D, Zahler R, et al. Manne V, et al. Among authors: zahler r. Oncogene. 1995 May 4;10(9):1763-79. Oncogene. 1995. PMID: 7753553

2

Phosphinyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase.

Patel DV, Gordon EM, Schmidt RJ, Weller HN, Young MG, Zahler R, Barbacid M, Carboni JM, Gullo-Brown JL, Hunihan L, et al. Patel DV, et al. Among authors: zahler r. J Med Chem. 1995 Feb 3;38(3):435-42. doi: 10.1021/jm00003a006. J Med Chem. 1995. PMID: 7853336

3

Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.

Leftheris K, Kline T, Vite GD, Cho YH, Bhide RS, Patel DV, Patel MM, Schmidt RJ, Weller HN, Andahazy ML, Carboni JM, Gullo-Brown JL, Lee FY, Ricca C, Rose WC, Yan N, Barbacid M, Hunt JT, Meyers CA, Seizinger BR, Zahler R, Manne V. Leftheris K, et al. Among authors: zahler r. J Med Chem. 1996 Jan 5;39(1):224-36. doi: 10.1021/jm950642a. J Med Chem. 1996. PMID: 8568812

4

Broad-spectrum antiviral activity of the acyclic guanosine phosphonate (R,S)-HPMPG.

Terry BJ, Mazina KE, Tuomari AV, Haffey ML, Hagen M, Feldman A, Slusarchyk WA, Young MG, Zahler R, Field AK. Terry BJ, et al. Among authors: zahler r. Antiviral Res. 1988 Dec 1;10(4-5):235-51. doi: 10.1016/0166-3542(88)90034-4. Antiviral Res. 1988. PMID: 2852486

5

Antiviral properties of aminodiol inhibitors against human immunodeficiency virus and protease.

Bechtold CM, Patick AK, Alam M, Greytok J, Tino JA, Chen P, Gordon E, Ahmad S, Barrish JC, Zahler R, et al. Bechtold CM, et al. Among authors: zahler r. Antimicrob Agents Chemother. 1995 Feb;39(2):374-9. doi: 10.1128/AAC.39.2.374. Antimicrob Agents Chemother. 1995. PMID: 7726501 Free PMC article.

6

Aminodiol HIV protease inhibitors. Synthesis and structure-activity relationships of P1/P1' compounds: correlation between lipophilicity and cytotoxicity.

Chen P, Cheng PT, Alam M, Beyer BD, Bisacchi GS, Dejneka T, Evans AJ, Greytok JA, Hermsmeier MA, Humphreys WG, Jacobs GA, Kocy O, Lin PF, Lis KA, Marella MA, Ryono DE, Sheaffer AK, Spergel SH, Sun CQ, Tino JA, Vite G, Colonno RJ, Zahler R, Barrish JC. Chen P, et al. Among authors: zahler r. J Med Chem. 1996 May 10;39(10):1991-2007. doi: 10.1021/jm950717a. J Med Chem. 1996. PMID: 8642558

7

Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase.

Bisacchi GS, Slusarchyk WA, Bolton SA, Hartl KS, Jacobs G, Mathur A, Meng W, Ogletree ML, Pi Z, Sutton JC, Treuner U, Zahler R, Zhao G, Seiler SM. Bisacchi GS, et al. Among authors: zahler r. Bioorg Med Chem Lett. 2004 May 3;14(9):2227-31. doi: 10.1016/j.bmcl.2004.02.011. Bioorg Med Chem Lett. 2004. PMID: 15081014

8

Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus.

Innaimo SF, Seifer M, Bisacchi GS, Standring DN, Zahler R, Colonno RJ. Innaimo SF, et al. Among authors: zahler r. Antimicrob Agents Chemother. 1997 Jul;41(7):1444-8. doi: 10.1128/AAC.41.7.1444. Antimicrob Agents Chemother. 1997. PMID: 9210663 Free PMC article.

9

Amino(methyl) pyrrolidines as novel scaffolds for factor Xa inhibitors.

Shi Y, Sitkoff D, Zhang J, Han W, Hu Z, Stein PD, Wang Y, Kennedy LJ, O'Connor SP, Ahmad S, Liu EC, Seiler SM, Lam PY, Robl JA, Macor JE, Atwal KS, Zahler R. Shi Y, et al. Among authors: zahler r. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5952-8. doi: 10.1016/j.bmcl.2007.07.063. Epub 2007 Aug 21. Bioorg Med Chem Lett. 2007. PMID: 17855089

10

Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors.

Shi Y, Zhang J, Stein PD, Shi M, O'Connor SP, Bisaha SN, Li C, Atwal KS, Bisacchi GS, Sitkoff D, Pudzianowski AT, Liu EC, Hartl KS, Seiler SM, Youssef S, Steinbacher TE, Schumacher WA, Rendina AR, Bozarth JM, Peterson TL, Zhang G, Zahler R. Shi Y, et al. Among authors: zahler r. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5453-8. doi: 10.1016/j.bmcl.2005.08.107. Epub 2005 Oct 5. Bioorg Med Chem Lett. 2005. PMID: 16213711

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