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Mitochondrial STAT3 contributes to transformation of Barrett's epithelial cells that express oncogenic Ras in a p53-independent fashion.
Yu C, Huo X, Agoston AT, Zhang X, Theiss AL, Cheng E, Zhang Q, Zaika A, Pham TH, Wang DH, Lobie PE, Odze RD, Spechler SJ, Souza RF. Yu C, et al. Among authors: zaika a. Am J Physiol Gastrointest Liver Physiol. 2015 Aug 1;309(3):G146-61. doi: 10.1152/ajpgi.00462.2014. Epub 2015 Jun 4. Am J Physiol Gastrointest Liver Physiol. 2015. PMID: 26045618 Free PMC article.
p53 has a direct apoptogenic role at the mitochondria.
Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM. Mihara M, et al. Among authors: zaika a. Mol Cell. 2003 Mar;11(3):577-90. doi: 10.1016/s1097-2765(03)00050-9. Mol Cell. 2003. PMID: 12667443
deltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo.
Petrenko O, Zaika A, Moll UM. Petrenko O, et al. Among authors: zaika a. Mol Cell Biol. 2003 Aug;23(16):5540-55. doi: 10.1128/MCB.23.16.5540-5555.2003. Mol Cell Biol. 2003. PMID: 12897129 Free PMC article.
TP73, despite significant homology to TP53, is not a classic tumor suppressor gene, since it exhibits upregulation of nonmutated products in human tumors and lacks a tumor phenotype in p73-deficient mice. We recently reported that an N-terminally truncated isoform, …
TP73, despite significant homology to TP53, is not a classic tumor suppressor gene, since it exhibits upregulation of nonmutated prod …
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