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Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.
Jacobsen JS, Comery TA, Martone RL, Elokdah H, Crandall DL, Oganesian A, Aschmies S, Kirksey Y, Gonzales C, Xu J, Zhou H, Atchison K, Wagner E, Zaleska MM, Das I, Arias RL, Bard J, Riddell D, Gardell SJ, Abou-Gharbia M, Robichaud A, Magolda R, Vlasuk GP, Bjornsson T, Reinhart PH, Pangalos MN. Jacobsen JS, et al. Among authors: zaleska mm. Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8754-9. doi: 10.1073/pnas.0710823105. Epub 2008 Jun 16. Proc Natl Acad Sci U S A. 2008. PMID: 18559859 Free PMC article.
Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke.
Feuerstein GZ, Zaleska MM, Krams M, Wang X, Day M, Rutkowski JL, Finklestein SP, Pangalos MN, Poole M, Stiles GL, Ruffolo RR, Walsh FL. Feuerstein GZ, et al. Among authors: zaleska mm. J Cereb Blood Flow Metab. 2008 Jan;28(1):217-9. doi: 10.1038/sj.jcbfm.9600516. Epub 2007 Jun 20. J Cereb Blood Flow Metab. 2008. PMID: 17579658 Review.
Multimodal magnetic resonance imaging for assessing evolution of ischemic penumbra: a key translational medicine strategy to manage the risk of developing novel therapies for acute ischemic stroke.
Chavez JC, Zaleska MM, Wang X, Wood A, Hurko O, Pangalos MN, Feuerstein GZ. Chavez JC, et al. Among authors: zaleska mm. J Cereb Blood Flow Metab. 2009 Jan;29(1):217-9. doi: 10.1038/jcbfm.2008.103. Epub 2008 Sep 3. J Cereb Blood Flow Metab. 2009. PMID: 18766199
Neuroprotective profile of novel SRC kinase inhibitors in rodent models of cerebral ischemia.
Liang S, Pong K, Gonzales C, Chen Y, Ling HP, Mark RJ, Boschelli F, Boschelli DH, Ye F, Barrios Sosa AC, Mansour TS, Frost P, Wood A, Pangalos MN, Zaleska MM. Liang S, et al. Among authors: zaleska mm. J Pharmacol Exp Ther. 2009 Dec;331(3):827-35. doi: 10.1124/jpet.109.156562. Epub 2009 Sep 9. J Pharmacol Exp Ther. 2009. PMID: 19741150
Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
Mayer SC, Kreft AF, Harrison B, Abou-Gharbia M, Antane M, Aschmies S, Atchison K, Chlenov M, Cole DC, Comery T, Diamantidis G, Ellingboe J, Fan K, Galante R, Gonzales C, Ho DM, Hoke ME, Hu Y, Huryn D, Jain U, Jin M, Kremer K, Kubrak D, Lin M, Lu P, Magolda R, Martone R, Moore W, Oganesian A, Pangalos MN, Porte A, Reinhart P, Resnick L, Riddell DR, Sonnenberg-Reines J, Stock JR, Sun SC, Wagner E, Wang T, Woller K, Xu Z, Zaleska MM, Zeldis J, Zhang M, Zhou H, Jacobsen JS. Mayer SC, et al. Among authors: zaleska mm. J Med Chem. 2008 Dec 11;51(23):7348-51. doi: 10.1021/jm801252w. J Med Chem. 2008. PMID: 19012391
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