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Venous angioplasty in multiple sclerosis: neurological outcome at two years in a cohort of relapsing-remitting patients.
Salvi F, Bartolomei I, Buccellato E, Galeotti R, Zamboni P. Salvi F, et al. Funct Neurol. 2012 Jan-Mar;27(1):55-9. Funct Neurol. 2012. PMID: 22687168 Free PMC article. Clinical Trial.
The annual relapse rate of MS was significantly lower post-procedure (0.45±0.62 vs 0.76±0.99; p=0.021), although it increased in four patients. The EDSS score two years after treatment was significantly lower compared to the EDSS score recorded at the examination two years …
The annual relapse rate of MS was significantly lower post-procedure (0.45±0.62 vs 0.76±0.99; p=0.021), although it increased in four …
Reflux elimination without any ablation or disconnection of the saphenous vein. A haemodynamic model for venous surgery.
Zamboni P, Cisno C, Marchetti F, Quaglio D, Mazza P, Liboni A. Zamboni P, et al. Eur J Vasc Endovasc Surg. 2001 Apr;21(4):361-9. doi: 10.1053/ejvs.2001.1338. Eur J Vasc Endovasc Surg. 2001. PMID: 11359339
All air-plethysmographic parameters, with the exception of Ejection Fraction, improved significantly: Venous Volume changed from 150+/-9 ml to 114+/-7 ml (p <0.0001), Venous Filling Index from 4.9+/-0.5 ml/s to 2.3+/-0.2 ml/s ( p <0.0001), and Residual Volume …
All air-plethysmographic parameters, with the exception of Ejection Fraction, improved significantly: Venous Volume changed from 150+/-9 ml …
Intracranial venous haemodynamics in multiple sclerosis.
Zamboni P, Menegatti E, Bartolomei I, Galeotti R, Malagoni AM, Tacconi G, Salvi F. Zamboni P, et al. Curr Neurovasc Res. 2007 Nov;4(4):252-8. doi: 10.2174/156720207782446298. Curr Neurovasc Res. 2007. PMID: 18045150
. -1.3 +/-2.6 cm/sec in MS, respectively, p<0.0001). Consequently, RI was dramatically increased in the MS group, affecting impedance of cerebral venous drainage (0.48+/-0.04 in controls vs. 1.1 +/-0.08 in MS, respectively p<0.0001). Therefore, the detection o …
. -1.3 +/-2.6 cm/sec in MS, respectively, p<0.0001). Consequently, RI was dramatically increased in the MS group, affecting impeda …
Soluble receptor for advanced glycation end products in multiple sclerosis: a potential marker of disease severity.
Sternberg Z, Weinstock-Guttman B, Hojnacki D, Zamboni P, Zivadinov R, Chadha K, Lieberman A, Kazim L, Drake A, Rocco P, Grazioli E, Munschauer F. Sternberg Z, et al. Mult Scler. 2008 Jul;14(6):759-63. doi: 10.1177/1352458507088105. Epub 2008 May 27. Mult Scler. 2008. PMID: 18505774
RESULTS: Serum levels of sRAGE were found to be significantly lower in MS patients compared to levels in healthy controls (p = 0.005). A trend toward lower levels of serum sRAGE was observed in female MS patients compared to their male counterparts (p = 0.05). ...
RESULTS: Serum levels of sRAGE were found to be significantly lower in MS patients compared to levels in healthy controls (p = 0.005) …
Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis.
Zamboni P, Galeotti R, Menegatti E, Malagoni AM, Tacconi G, Dall'Ara S, Bartolomei I, Salvi F. Zamboni P, et al. J Neurol Neurosurg Psychiatry. 2009 Apr;80(4):392-9. doi: 10.1136/jnnp.2008.157164. Epub 2008 Dec 5. J Neurol Neurosurg Psychiatry. 2009. PMID: 19060024 Free PMC article.
RESULTS: CDMS and TCCS-ECD venous outflow anomalies were dramatically associated (OR 43, 95% CI 29 to 65, p<0.0001). Subsequently, venography demonstrated in CDMS, and not in controls, the presence of multiple severe extracranial stenosis, affecting the principal cerebr …
RESULTS: CDMS and TCCS-ECD venous outflow anomalies were dramatically associated (OR 43, 95% CI 29 to 65, p<0.0001). Subsequently, …
The value of cerebral Doppler venous haemodynamics in the assessment of multiple sclerosis.
Zamboni P, Menegatti E, Galeotti R, Malagoni AM, Tacconi G, Dall'Ara S, Bartolomei I, Salvi F. Zamboni P, et al. J Neurol Sci. 2009 Jul 15;282(1-2):21-7. doi: 10.1016/j.jns.2008.11.027. Epub 2009 Jan 13. J Neurol Sci. 2009. PMID: 19144359
However, the detection >or=2 parameters in the same subject, never observed in controls, perfectly overlapped the diagnosis of MS (value, 95%CI: sensitivity 100%, 97-100; specificity 100%, 98-100; positive predictive value 100%, 97-100, negative predictive value 100%, 98-100; …
However, the detection >or=2 parameters in the same subject, never observed in controls, perfectly overlapped the diagnosis of MS (value, …
Anomalous venous blood flow and iron deposition in multiple sclerosis.
Singh AV, Zamboni P. Singh AV, et al. J Cereb Blood Flow Metab. 2009 Dec;29(12):1867-78. doi: 10.1038/jcbfm.2009.180. Epub 2009 Sep 2. J Cereb Blood Flow Metab. 2009. PMID: 19724286 Review.
A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiency.
Zamboni P, Galeotti R, Menegatti E, Malagoni AM, Gianesini S, Bartolomei I, Mascoli F, Salvi F. Zamboni P, et al. J Vasc Surg. 2009 Dec;50(6):1348-58.e1-3. doi: 10.1016/j.jvs.2009.07.096. J Vasc Surg. 2009. PMID: 19958985

CCSVI endovascular treatment significantly improved MS clinical outcome measures, especially in the RR group: the rate of relapse-free patients changed from 27% to 50% postoperatively (P < .001) and of MR Gad+ lesions from 50% to 12% (P < .0001). The Multiple

CCSVI endovascular treatment significantly improved MS clinical outcome measures, especially in the RR group: the rate of relapse-free patie …
The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics.
Zamboni P, Menegatti E, Weinstock-Guttman B, Schirda C, Cox JL, Malagoni AM, Hojanacki D, Kennedy C, Carl E, Dwyer MG, Bergsland N, Galeotti R, Hussein S, Bartolomei I, Salvi F, Zivadinov R. Zamboni P, et al. Funct Neurol. 2009 Jul-Sep;24(3):133-8. Funct Neurol. 2009. PMID: 20018140 Clinical Trial.
Compared with the HCs, the CCSVI-MS patients showed a significantly lower net CSF flow (p=0.027) which was highly associated with the VHISS (r=0.8280, r2=0.6855; p=0.0001). ...
Compared with the HCs, the CCSVI-MS patients showed a significantly lower net CSF flow (p=0.027) which was highly associated with the …
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