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Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2'-deoxyguanosine.
Goodenough AK, Kozekov ID, Zang H, Choi JY, Guengerich FP, Harris TM, Rizzo CJ. Goodenough AK, et al. Among authors: zang h. Chem Res Toxicol. 2005 Nov;18(11):1701-14. doi: 10.1021/tx050141k. Chem Res Toxicol. 2005. PMID: 16300379 Free PMC article.
DNA adduct bypass polymerization by Sulfolobus solfataricus DNA polymerase Dpo4: analysis and crystal structures of multiple base pair substitution and frameshift products with the adduct 1,N2-ethenoguanine.
Zang H, Goodenough AK, Choi JY, Irimia A, Loukachevitch LV, Kozekov ID, Angel KC, Rizzo CJ, Egli M, Guengerich FP. Zang H, et al. J Biol Chem. 2005 Aug 19;280(33):29750-64. doi: 10.1074/jbc.M504756200. Epub 2005 Jun 17. J Biol Chem. 2005. PMID: 15965231
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