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The once-daily human GLP-1 analogue liraglutide impacts appetite and energy intake in patients with type 2 diabetes after short-term treatment.
Flint A, Kapitza C, Zdravkovic M. Flint A, et al. Diabetes Obes Metab. 2013 Oct;15(10):958-62. doi: 10.1111/dom.12108. Epub 2013 Apr 23. Diabetes Obes Metab. 2013. PMID: 23551925 Clinical Trial.
GLP-1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide.
Hegedüs L, Moses AC, Zdravkovic M, Le Thi T, Daniels GH. Hegedüs L, et al. J Clin Endocrinol Metab. 2011 Mar;96(3):853-60. doi: 10.1210/jc.2010-2318. Epub 2011 Jan 5. J Clin Endocrinol Metab. 2011. PMID: 21209033 Clinical Trial.
Effect of three different injection sites on the pharmacokinetics of the once-daily human GLP-1 analogue liraglutide.
Kapitza C, Zdravkovic M, Zijlstra E, Segel S, Heise T, Flint A. Kapitza C, et al. J Clin Pharmacol. 2011 Jun;51(6):951-5. doi: 10.1177/0091270010374474. Epub 2010 Jul 29. J Clin Pharmacol. 2011. PMID: 20671294 Clinical Trial. No abstract available.
Metabolism and excretion of the once-daily human glucagon-like peptide-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase.
Malm-Erjefält M, Bjørnsdottir I, Vanggaard J, Helleberg H, Larsen U, Oosterhuis B, van Lier JJ, Zdravkovic M, Olsen AK. Malm-Erjefält M, et al. Drug Metab Dispos. 2010 Nov;38(11):1944-53. doi: 10.1124/dmd.110.034066. Epub 2010 Aug 13. Drug Metab Dispos. 2010. PMID: 20709939 Clinical Trial.
Effect on the Gastrointestinal Absorption of Drugs from Different Classes in the Biopharmaceutics Classification System, When Treating with Liraglutide.
Malm-Erjefält M, Ekblom M, Vouis J, Zdravkovic M, Lennernäs H. Malm-Erjefält M, et al. Mol Pharm. 2015 Nov 2;12(11):4166-73. doi: 10.1021/acs.molpharmaceut.5b00278. Epub 2015 Oct 12. Mol Pharm. 2015. PMID: 26426736 Clinical Trial.
The once-daily human glucagon-like peptide-1 (GLP-1) analog liraglutide improves postprandial glucose levels in type 2 diabetes patients.
Flint A, Kapitza C, Hindsberger C, Zdravkovic M. Flint A, et al. Adv Ther. 2011 Mar;28(3):213-26. doi: 10.1007/s12325-010-0110-x. Epub 2011 Feb 17. Adv Ther. 2011. PMID: 21340616 Clinical Trial.
METHODS: Eighteen subjects with type 2 diabetes, aged 18-70 years, with a body mass index of 18.5-40 kg/m(2) and HbA(1c) of 7.0%-9.5% were included in this single-centre, randomized, placebo-controlled, double-blind, two-period, cross over trial. ...
METHODS: Eighteen subjects with type 2 diabetes, aged 18-70 years, with a body mass index of 18.5-40 kg/m(2) and HbA(1c) of 7.0%-9.5% …
Treatment with liraglutide--a once-daily GLP-1 analog--does not reduce the bioavailability of ethinyl estradiol/levonorgestrel taken as an oral combination contraceptive drug.
Jacobsen LV, Vouis J, Hindsberger C, Zdravkovic M. Jacobsen LV, et al. J Clin Pharmacol. 2011 Dec;51(12):1696-703. doi: 10.1177/0091270010389471. Epub 2011 Jan 12. J Clin Pharmacol. 2011. PMID: 21228406 Clinical Trial.
Influence of hepatic impairment on pharmacokinetics of the human GLP-1 analogue, liraglutide.
Flint A, Nazzal K, Jagielski P, Hindsberger C, Zdravkovic M. Flint A, et al. Br J Clin Pharmacol. 2010 Dec;70(6):807-14. doi: 10.1111/j.1365-2125.2010.03762.x. Br J Clin Pharmacol. 2010. PMID: 21175436 Free PMC article. Clinical Trial.
Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation.
Bjerre Knudsen L, Madsen LW, Andersen S, Almholt K, de Boer AS, Drucker DJ, Gotfredsen C, Egerod FL, Hegelund AC, Jacobsen H, Jacobsen SD, Moses AC, Mølck AM, Nielsen HS, Nowak J, Solberg H, Thi TD, Zdravkovic M, Moerch U. Bjerre Knudsen L, et al. Endocrinology. 2010 Apr;151(4):1473-86. doi: 10.1210/en.2009-1272. Epub 2010 Mar 4. Endocrinology. 2010. PMID: 20203154 Clinical Trial.
Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide.
Jacobsen LV, Hindsberger C, Robson R, Zdravkovic M. Jacobsen LV, et al. Br J Clin Pharmacol. 2009 Dec;68(6):898-905. doi: 10.1111/j.1365-2125.2009.03536.x. Br J Clin Pharmacol. 2009. PMID: 20002084 Free PMC article. Clinical Trial.
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