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PhnY and PhnZ comprise a new oxidative pathway for enzymatic cleavage of a carbon-phosphorus bond.
McSorley FR, Wyatt PB, Martinez A, DeLong EF, Hove-Jensen B, Zechel DL. McSorley FR, et al. Among authors: zechel dl. J Am Chem Soc. 2012 May 23;134(20):8364-7. doi: 10.1021/ja302072f. Epub 2012 May 11. J Am Chem Soc. 2012. PMID: 22564006
Rebeccamycin and staurosporine biosynthesis: insight into the mechanisms of the flavin-dependent monooxygenases RebC and StaC.
Groom K, Bhattacharya A, Zechel DL. Groom K, et al. Among authors: zechel dl. Chembiochem. 2011 Feb 11;12(3):396-400. doi: 10.1002/cbic.201000580. Epub 2011 Jan 11. Chembiochem. 2011. PMID: 21290541 No abstract available.
New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by Streptomyces asterosporus DSM 41452 and Its Mutant.
Zhang S, Zhu J, Zechel DL, Jessen-Trefzer C, Eastman RT, Paululat T, Bechthold A. Zhang S, et al. Among authors: zechel dl. Chembiochem. 2018 Feb 2;19(3):272-279. doi: 10.1002/cbic.201700428. Epub 2017 Dec 18. Chembiochem. 2018. PMID: 29148157 Free PMC article.
Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA-Specified Leu-tRNA(UUA) Molecule.
Zhu XM, Hackl S, Thaker MN, Kalan L, Weber C, Urgast DS, Krupp EM, Brewer A, Vanner S, Szawiola A, Yim G, Feldmann J, Bechthold A, Wright GD, Zechel DL. Zhu XM, et al. Among authors: zechel dl. Chembiochem. 2015 Nov;16(17):2498-506. doi: 10.1002/cbic.201500402. Epub 2015 Oct 22. Chembiochem. 2015. PMID: 26374477
Changing Biosynthetic Profiles by Expressing bldA in Streptomyces Strains.
Gessner A, Heitzler T, Zhang S, Klaus C, Murillo R, Zhao H, Vanner S, Zechel DL, Bechthold A. Gessner A, et al. Among authors: zechel dl. Chembiochem. 2015 Oct 12;16(15):2244-52. doi: 10.1002/cbic.201500297. Epub 2015 Sep 23. Chembiochem. 2015. PMID: 26255983
Methylphosphonic Acid Biosynthesis and Catabolism in Pelagic Archaea and Bacteria.
Ulrich EC, Kamat SS, Hove-Jensen B, Zechel DL. Ulrich EC, et al. Among authors: zechel dl. Methods Enzymol. 2018;605:351-426. doi: 10.1016/bs.mie.2018.01.039. Epub 2018 May 3. Methods Enzymol. 2018. PMID: 29909833 Review.
Crystal structure of PhnZ in complex with substrate reveals a di-iron oxygenase mechanism for catabolism of organophosphonates.
van Staalduinen LM, McSorley FR, Schiessl K, S├ęguin J, Wyatt PB, Hammerschmidt F, Zechel DL, Jia Z. van Staalduinen LM, et al. Among authors: zechel dl. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5171-6. doi: 10.1073/pnas.1320039111. Epub 2014 Mar 21. Proc Natl Acad Sci U S A. 2014. PMID: 24706911 Free PMC article.
Physiological role of phnP-specified phosphoribosyl cyclic phosphodiesterase in catabolism of organophosphonic acids by the carbon-phosphorus lyase pathway.
Hove-Jensen B, McSorley FR, Zechel DL. Hove-Jensen B, et al. Among authors: zechel dl. J Am Chem Soc. 2011 Mar 16;133(10):3617-24. doi: 10.1021/ja1102713. Epub 2011 Feb 22. J Am Chem Soc. 2011. PMID: 21341651
Phosphonate Biochemistry.
Horsman GP, Zechel DL. Horsman GP, et al. Among authors: zechel dl. Chem Rev. 2017 Apr 26;117(8):5704-5783. doi: 10.1021/acs.chemrev.6b00536. Epub 2016 Oct 27. Chem Rev. 2017. PMID: 27787975 Review.
PhnK: Another Piece of the Carbon-Phosphorus Lyase Puzzle.
Zechel DL. Zechel DL. Structure. 2016 Jan 5;24(1):3-4. doi: 10.1016/j.str.2015.12.004. Structure. 2016. PMID: 26745526
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