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Page 1
Clinical Risk Score for Persistent Postconcussion Symptoms Among Children With Acute Concussion in the ED.
Zemek R, Barrowman N, Freedman SB, Gravel J, Gagnon I, McGahern C, Aglipay M, Sangha G, Boutis K, Beer D, Craig W, Burns E, Farion KJ, Mikrogianakis A, Barlow K, Dubrovsky AS, Meeuwisse W, Gioia G, Meehan WP 3rd, Beauchamp MH, Kamil Y, Grool AM, Hoshizaki B, Anderson P, Brooks BL, Yeates KO, Vassilyadi M, Klassen T, Keightley M, Richer L, DeMatteo C, Osmond MH; Pediatric Emergency Research Canada (PERC) Concussion Team. Zemek R, et al. JAMA. 2016 Mar 8;315(10):1014-25. doi: 10.1001/jama.2016.1203. JAMA. 2016. PMID: 26954410
DESIGN, SETTING, AND PARTICIPANTS: Prospective, multicenter cohort study (Predicting and Preventing Postconcussive Problems in Pediatrics [5P]) enrolled young patients (aged 5-<18 years) who presented within 48 hours of an acute head injury at 1 of 9 pediatric emergency …
DESIGN, SETTING, AND PARTICIPANTS: Prospective, multicenter cohort study (Predicting and Preventing Postconcussive Problems in Pediatrics [ …
Association of Persistent Postconcussion Symptoms With Pediatric Quality of Life.
Novak Z, Aglipay M, Barrowman N, Yeates KO, Beauchamp MH, Gravel J, Freedman SB, Gagnon I, Gioia G, Boutis K, Burns E, Ledoux AA, Osmond MH, Zemek RL; Pediatric Emergency Research Canada Predicting Persistent Postconcussive Problems in Pediatrics (PERC 5P) Concussion Team. Novak Z, et al. Among authors: zemek rl. JAMA Pediatr. 2016 Dec 5;170(12):e162900. doi: 10.1001/jamapediatrics.2016.2900. Epub 2016 Dec 5. JAMA Pediatr. 2016. PMID: 27775762
DESIGN, SETTING, AND PARTICIPANTS: In a prospective, multicenter cohort study (Predicting Persistent Postconcussive Problems in Pediatrics [5P]) from August 14, 2013, to September 30, 2014, children aged 5 to 18 years who presented to the emergency department within 48 hou …
DESIGN, SETTING, AND PARTICIPANTS: In a prospective, multicenter cohort study (Predicting Persistent Postconcussive Problems in Pediatrics [ …
Balance Markers in Adolescents at 1 Month Postconcussion.
Rochefort C, Walters-Stewart C, Aglipay M, Barrowman N, Zemek R, Sveistrup H. Rochefort C, et al. Among authors: zemek r. Orthop J Sports Med. 2017 Mar 17;5(3):2325967117695507. doi: 10.1177/2325967117695507. eCollection 2017 Mar. Orthop J Sports Med. 2017. PMID: 28451603 Free PMC article.
Identifying Persistent Postconcussion Symptom Risk in a Pediatric Sports Medicine Clinic.
Howell DR, Zemek R, Brilliant AN, Mannix RC, Master CL, Meehan WP 3rd. Howell DR, et al. Among authors: zemek r. Am J Sports Med. 2018 Nov;46(13):3254-3261. doi: 10.1177/0363546518796830. Epub 2018 Sep 28. Am J Sports Med. 2018. PMID: 30265817
Nine variables were used to calculate the 5P clinical risk score, and we assessed the association between the 5P clinical risk score and PPCS occurrence. ...Among the individual participants who received a high 5P clinical risk score (9-12), the majority (82% …
Nine variables were used to calculate the 5P clinical risk score, and we assessed the association between the 5P clinical risk …
Association between ondansetron use and symptom persistence in children with concussions: A 5P substudy.
Gravel J, Boutis K, Tang K, Beauchamp MH, Freedman SB, Dubrovsky AS, Gagnon I, Momoli F, Zemek R. Gravel J, et al. Among authors: zemek r. CJEM. 2019 Mar;21(2):204-210. doi: 10.1017/cem.2018.384. Epub 2018 Jun 7. CJEM. 2019. PMID: 29877168
For the current study, only 5P participants who reported nausea and/or vomiting in the ED were eligible. The exposure of interest was ondansetron administration; the comparison group included all other participants. ...RESULTS: Among the 3,063 children included in the 5 …
For the current study, only 5P participants who reported nausea and/or vomiting in the ED were eligible. The exposure of interest was …
Predicting Wellness After Pediatric Concussion.
Beauchamp MH, Tang K, Yeates KO, Anderson P, Brooks BL, Keightley M, Désiré N, Boutis K, Gagnon I, Gravel J, Dubrovsky AS, Zemek R; 5P PERC Concussion Team. Beauchamp MH, et al. Among authors: zemek r. J Int Neuropsychol Soc. 2019 Apr;25(4):375-389. doi: 10.1017/S1355617719000286. J Int Neuropsychol Soc. 2019. PMID: 31050335
Derivation and Initial Validation of Clinical Phenotypes of Children Presenting with Concussion Acutely in the Emergency Department: Latent Class Analysis of a Multi-Center, Prospective Cohort, Observational Study.
Yeates KO, Tang K, Barrowman N, Freedman SB, Gravel J, Gagnon I, Sangha G, Boutis K, Beer D, Craig W, Burns E, Farion KJ, Mikrogianakis A, Barlow K, Dubrovsky AS, Meeuwisse W, Gioia G, Meehan WP 3rd, Beauchamp MH, Kamil Y, Grool AM, Hoshizaki B, Anderson P, Brooks BL, Vassilyadi M, Klassen T, Keightley M, Richer L, DeMatteo C, Osmond MH, Zemek R; Pediatric Emergency Research Canada (PERC) Predicting Persistent Postconcussive Problems in Pediatrics (5P) Concussion Team. Yeates KO, et al. Among authors: zemek r. J Neurotrauma. 2019 Jun;36(11):1758-1767. doi: 10.1089/neu.2018.6009. Epub 2019 Mar 6. J Neurotrauma. 2019. PMID: 30618356
Early versus delayed emergency department presentation following mild Traumatic Brain Injury and the presence of symptom at 1, 4 and 12 weeks in children.
Gravel J, Ledoux AA, Tang K, Yeates KO, Craig W, Osmond M, Boutis K, Burns E, Sangha G, Dubrovsky AS, Beer D, Zemek R. Gravel J, et al. Among authors: zemek r. Emerg Med J. 2020 Jun;37(6):338-343. doi: 10.1136/emermed-2019-209054. Epub 2020 Mar 5. Emerg Med J. 2020. PMID: 32139516
METHODS: This was a secondary analysis of a prospective cohort study conducted in nine Canadian paediatric EDs in 2013-2015 (5P study). Participants were children who suffered a head injury within the preceding 48 hours and met Zurich consensus concussion diagnostic criter …
METHODS: This was a secondary analysis of a prospective cohort study conducted in nine Canadian paediatric EDs in 2013-2015 (5P study …
Post-concussion symptom burden in children following motor vehicle collisions.
Lumba-Brown A, Tang K, Yeates KO, Zemek R; Pediatric Emergency Research Canada (PERC) 5P Concussion Team. Lumba-Brown A, et al. Among authors: zemek r. J Am Coll Emerg Physicians Open. 2020 Apr 24;1(5):938-946. doi: 10.1002/emp2.12056. eCollection 2020 Oct. J Am Coll Emerg Physicians Open. 2020. PMID: 33145544 Free PMC article.
Association Between Preinjury Symptoms and Postconcussion Symptoms at 4 Weeks in Youth.
Ledoux AA, Tang K, Gagnon I, Osmond MH, Yeates KO, Healey K, Gioia GA, Zemek RL; Pediatric Emergency Research Canada (PERC) Concussion Team. Ledoux AA, et al. Among authors: zemek rl. J Head Trauma Rehabil. 2022 Mar-Apr 01;37(2):E90-E101. doi: 10.1097/HTR.0000000000000681. J Head Trauma Rehabil. 2022. PMID: 33935222
DESIGN: A planned secondary analysis of a prospective, multicenter cohort study (Predicting Persistent Post-concussive Problems in Pediatrics or 5P). Primary outcome was PPCS at 4 weeks, defined as 3 or more new or worsening individual symptoms compared with the preinjury …
DESIGN: A planned secondary analysis of a prospective, multicenter cohort study (Predicting Persistent Post-concussive Problems in Pediatric …
Paediatric post-concussive symptoms: symptom clusters and clinical phenotypes.
Lyons TW, Mannix R, Tang K, Yeates KO, Sangha G, Burns EC, Beer D, Dubrovsky AS, Gagnon I, Gravel J, Freedman SB, Craig W, Boutis K, Osmond MH, Gioia G, Zemek R; Pediatric Emergency Research Canada (PERC) 5P Concussion Team. Lyons TW, et al. Among authors: zemek r. Br J Sports Med. 2022 Jul;56(14):785-791. doi: 10.1136/bjsports-2021-105193. Epub 2022 Mar 10. Br J Sports Med. 2022. PMID: 35273038
METHODS: We performed a secondary analysis of the prospective, multicentre Predicting and Preventing Post-concussive Problems in Pediatrics (5P) cohort study, evaluating children 5-17 years of age presenting within 48 hours of an acute concussion. ...Analyses of symptom an …
METHODS: We performed a secondary analysis of the prospective, multicentre Predicting and Preventing Post-concussive Problems in Pediatrics …
Early analgesic administration and headache presence 7 days post-concussion in children.
Ledoux A-, Tang K, Freedman SB, Gravel J, Boutis K, Yeates KO, Mannix RC, Richer LR, Bell MJ, Zemek RL; Pediatric Emergency Research Canada 5P Study Group. Ledoux A-, et al. Among authors: zemek rl. CJEM. 2022 Dec;24(8):876-884. doi: 10.1007/s43678-022-00367-0. Epub 2022 Sep 15. CJEM. 2022. PMID: 36107402
METHODS: A secondary analysis of the Predicting and Preventing Post-concussive Problems in Pediatrics (5P) prospective cohort study was conducted. Individuals aged 5-18 years with acute concussion presenting to nine Canadian pediatric emergency departments (ED) were enroll …
METHODS: A secondary analysis of the Predicting and Preventing Post-concussive Problems in Pediatrics (5P) prospective cohort study w …
Association Between Early Return to School Following Acute Concussion and Symptom Burden at 2 Weeks Postinjury.
Vaughan CG, Ledoux AA, Sady MD, Tang K, Yeates KO, Sangha G, Osmond MH, Freedman SB, Gravel J, Gagnon I, Craig W, Burns E, Boutis K, Beer D, Gioia G, Zemek R; PERC 5P Concussion Team. Vaughan CG, et al. Among authors: zemek r. JAMA Netw Open. 2023 Jan 3;6(1):e2251839. doi: 10.1001/jamanetworkopen.2022.51839. JAMA Netw Open. 2023. PMID: 36662524 Free PMC article.
Can quantitative susceptibility mapping help diagnose and predict recovery of concussion in children? An A-CAP study.
Sader N, Gobbi D, Goodyear B, Frayne R, Ware AL, Beauchamp MH, Craig WR, Doan Q, Zemek R, Riva-Cambrin J, Yeates KO; Pediatric Emergency Research Canada A-CAP study team. Sader N, et al. Among authors: zemek r. J Neurol Neurosurg Psychiatry. 2023 Mar;94(3):227-235. doi: 10.1136/jnnp-2022-329487. Epub 2022 Dec 14. J Neurol Neurosurg Psychiatry. 2023. PMID: 36517039
QSM Z-scores were also compared with the 5P score, the current clinical benchmark for predicting persistent postconcussion symptoms (PPCS), at 4 weeks postinjury, with PPCS defined using reliable change methods based on both participant and parent reports. ...The combinati …
QSM Z-scores were also compared with the 5P score, the current clinical benchmark for predicting persistent postconcussion symptoms ( …
Association of Posttraumatic Headache With Symptom Burden After Concussion in Children.
van Ierssel JJ, Tang K, Beauchamp M, Bresee N, Cortel-LeBlanc A, Craig W, Doan Q, Gravel J, Lyons T, Mannix R, Orr S, Zemek R, Yeates KO; Pediatric Emergency Research Canada A-CAP study team. van Ierssel JJ, et al. Among authors: zemek r. JAMA Netw Open. 2023 Mar 1;6(3):e231993. doi: 10.1001/jamanetworkopen.2023.1993. JAMA Netw Open. 2023. PMID: 36884251 Free PMC article.
Multivariable linear regression evaluated the association between headache phenotype and outcomes compared with the Predicting and Preventing Postconcussive Problems in Pediatrics (5P) clinical risk score and other covariates and confounders. Reliable change analyses exami …
Multivariable linear regression evaluated the association between headache phenotype and outcomes compared with the Predicting and Preventin …
Return to the Emergency Department Within 3 Months Following Pediatric Acute Concussion.
Engel J, van Ierssel JJ, Osmond MH, Tsampalieros A, Webster R, Zemek R. Engel J, et al. Among authors: zemek r. J Head Trauma Rehabil. 2023 Jul-Aug 01;38(4):319-328. doi: 10.1097/HTR.0000000000000852. Epub 2023 Feb 28. J Head Trauma Rehabil. 2023. PMID: 36854112
OBJECTIVE: To determine the proportion of concussed children returning to the emergency department (ED) for a concussion-related reason within 3 months of initial presentation and to determine which clinical composite score (5P or Post-Concussion Symptom Inventory) best pr …
OBJECTIVE: To determine the proportion of concussed children returning to the emergency department (ED) for a concussion-related reason with …
The association between symptom burden and processing speed and executive functioning at 4 and 12 weeks following pediatric concussion.
Sicard V, Ledoux AA, Tang K, Yeates KO, Brooks BL, Anderson P, Keightley M, Desire N, Beauchamp MH, Zemek R; Pediatric Emergency Research Canada (PERC) 5P Neuropsych team. Sicard V, et al. Among authors: zemek r. J Int Neuropsychol Soc. 2024 Jul;30(6):533-545. doi: 10.1017/S1355617724000043. Epub 2024 Jan 26. J Int Neuropsychol Soc. 2024. PMID: 38273645
Symptom Recovery in Children Aged 5 to 12 Years With Sport-Related and Non-Sport-Related Concussion.
Ledoux AA, Sicard V, Bijelic V, Barrowman N, van Ierssel J, Beer D, Boutis K, Burns E, Craig W, Freedman SB, Gagnon I, Gravel J, Sangha G, Yeates KO, Osmond M, Zemek R; Pediatric Emergency Research Canada (PERC) Predicting and Preventing Postconcussive Problems in Pediatrics (5P) Concussion Team. Ledoux AA, et al. Among authors: zemek r. JAMA Netw Open. 2024 Dec 2;7(12):e2448797. doi: 10.1001/jamanetworkopen.2024.48797. JAMA Netw Open. 2024. PMID: 39630449 Free PMC article.
Early Resumption of Physical Activity and Cognitive Outcomes at 4 Week Following Pediatric Concussion.
Sicard V, Zemek R, Bijelic V, Barrowman N, Yeates KO, Beauchamp MH, Brooks BL, Anderson P, Keightley M, Desire N, Ledoux AA; Pediatric Emergency Research Canada (PERC) 5P Neuropsych Team. Sicard V, et al. Among authors: zemek r. J Head Trauma Rehabil. 2025 Mar 13. doi: 10.1097/HTR.0000000000001050. Online ahead of print. J Head Trauma Rehabil. 2025. PMID: 40094546