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Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway.
Jiang YM, Wang Y, Tan HS, Yu T, Fan XM, Chen P, Zeng H, Huang M, Bi HC. Jiang YM, et al. Acta Pharmacol Sin. 2016 Mar;37(3):382-9. doi: 10.1038/aps.2015.120. Epub 2016 Jan 25. Acta Pharmacol Sin. 2016. PMID: 26806302 Free PMC article.
PPARĪ± regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C.
Chen Y, Wang Y, Huang Y, Zeng H, Hu B, Guan L, Zhang H, Yu AM, Johnson CH, Gonzalez FJ, Huang M, Bi H. Chen Y, et al. Carcinogenesis. 2017 Apr 1;38(4):474-483. doi: 10.1093/carcin/bgx023. Carcinogenesis. 2017. PMID: 28334197 Free PMC article.
SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells.
Tan H, Xu C, Zeng H, Wang Y, Li Y, Fan X, Chen P, Jiang Y, Chen X, Huang M, Bi H. Tan H, et al. J Pharmacol Sci. 2016 Feb;130(2):66-71. doi: 10.1016/j.jphs.2015.11.006. Epub 2015 Dec 12. J Pharmacol Sci. 2016. PMID: 26782648
Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism.
Chen P, Li J, Fan X, Zeng H, Deng R, Li D, Huang M, Bi H. Chen P, et al. Eur J Pharmacol. 2015 Oct 15;765:131-9. doi: 10.1016/j.ejphar.2015.08.029. Epub 2015 Aug 20. Eur J Pharmacol. 2015. PMID: 26297978
3',4',5',5,7-pentamethoxyflavone sensitizes Cisplatin-resistant A549 cells to Cisplatin by inhibition of Nrf2 pathway.
Hou X, Bai X, Gou X, Zeng H, Xia C, Zhuang W, Chen X, Zhao Z, Huang M, Jin J. Hou X, et al. Mol Cells. 2015 May;38(5):396-401. doi: 10.14348/molcells.2015.2183. Epub 2015 Mar 31. Mol Cells. 2015. PMID: 25843086 Free PMC article.
Effects of nicotinamide N-methyltransferase on PANC-1 cells proliferation, metastatic potential and survival under metabolic stress.
Yu T, Wang YT, Chen P, Li YH, Chen YX, Zeng H, Yu AM, Huang M, Bi HC. Yu T, et al. Cell Physiol Biochem. 2015;35(2):710-21. doi: 10.1159/000369731. Epub 2015 Jan 28. Cell Physiol Biochem. 2015. PMID: 25592232
Dynamic and coordinated regulation of KEAP1-NRF2-ARE and p53/p21 signaling pathways is associated with acetaminophen injury responsive liver regeneration.
Fan X, Chen P, Tan H, Zeng H, Jiang Y, Wang Y, Wang Y, Hou X, Bi H, Huang M. Fan X, et al. Drug Metab Dispos. 2014 Sep;42(9):1532-9. doi: 10.1124/dmd.114.059394. Epub 2014 Jul 7. Drug Metab Dispos. 2014. PMID: 25002747
Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways.
Fan X, Jiang Y, Wang Y, Tan H, Zeng H, Wang Y, Chen P, Qu A, Gonzalez FJ, Huang M, Bi H. Fan X, et al. Drug Metab Dispos. 2014 Dec;42(12):1982-90. doi: 10.1124/dmd.114.059535. Epub 2014 Sep 12. Drug Metab Dispos. 2014. PMID: 25217484 Free PMC article.
Schisandrol B protects against cholestatic liver injury through pregnane X receptors.
Zeng H, Jiang Y, Chen P, Fan X, Li D, Liu A, Ma X, Xie W, Liu P, Gonzalez FJ, Huang M, Bi H. Zeng H, et al. Br J Pharmacol. 2017 Apr;174(8):672-688. doi: 10.1111/bph.13729. Epub 2017 Mar 16. Br J Pharmacol. 2017. PMID: 28128437 Free PMC article.
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