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Oesophageal motility and bolus transit abnormalities increase in parallel with the severity of gastro-oesophageal reflux disease
Savarino E, et al. Aliment Pharmacol Ther 2011. Among authors: Zentilin P. PMID 21671968
RESULTS: Increasing GERD severity was associated with decreased lower oesophageal sphincter resting pressure (P< 0.05) and distal oesophageal amplitude (P<0.01), higher prevalence of hiatal hernia (P<0.01) and increased prevalence of ineffective oesophageal motility (P<0.01). Patients with EO and BO had a significantly lower percentage of complete bolus transit compared with NERD and FH (P<0.01). Overall, abnormal bolus transit (ABT) for liquid swallows was found in 12% of FH, 20% of NERD, 54% of EO and 56% of BO (P<0.01). ...
RESULTS: Increasing GERD severity was associated with decreased lower oesophageal sphincter resting pressure (P< 0.05) and distal …
Lactulose breath test to assess oro-cecal transit delay and estimate esophageal dysmotility in scleroderma patients
Gemignani L, et al. Semin Arthritis Rheum 2013 - Clinical Trial. Among authors: Zentilin P. PMID 23352249
RESULTS: Thirty-one (63%) SSc patients presented ineffective esophageal motility (IEM) compared with 3 HVs (5%; P<0.01), 37 (74%) had an abnormal OCTT compared with 4 HVs (7%; P <0.01), and 16 (32%) had an altered GE compared with 4 HVs (7%; P <0.01). The median OCTT and gastric t½ were longer in SSc than in HVs (165 min vs. 101 min and 125 min vs. 78 min, respectively; P <0.01). ...
RESULTS: Thirty-one (63%) SSc patients presented ineffective esophageal motility (IEM) compared with 3 HVs (5%; P<0.01), 37 (74%) …
Reassessment of the role of methane production between irritable bowel syndrome and functional constipation
Furnari M, et al. J Gastrointestin Liver Dis 2012. Among authors: Zentilin P. PMID 22720304
Methane excretion was strictly related to chronic constipation (p<0.001). Median CH₄ excretion was higher in constipated patients compared with patients with normal daily stools (p=0.0406) and even more with patients complaining of diarrhea (p=0.0011). ...Mean methane excretion of "methane producers" was 30.3 ppm in functional constipation and 21.5 ppm in constipation-irritable bowel syndrome (C-IBS) (p=0.0458). ...
Methane excretion was strictly related to chronic constipation (p<0.001). Median CH₄ excretion was higher in constipated patients …
Prognostic role of mean platelet volume in patients with cirrhosis
Giannini EG, et al. Dig Liver Dis 2016. Among authors: Zentilin P. PMID 26699823
RESULTS: Median MPV values were not statistically different according to aetiology of liver disease (P=0.485) and disease severity both taking into consideration the Child-Pugh classification (P=0.438) and the Model for End-stage Liver Disease score (P=0.978). Median MPV values were not significantly different in 23 Child-Pugh class C patients who died or survived (9.15fL versus 9.10fL, P=0.794) during a 12-month follow-up. ...
RESULTS: Median MPV values were not statistically different according to aetiology of liver disease (P=0.485) and disease severity bo …
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