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Recent progress on antifungal drug development.
Zhai B, Lin X. Zhai B, et al. Curr Pharm Biotechnol. 2011 Aug;12(8):1255-62. doi: 10.2174/138920111796117292. Curr Pharm Biotechnol. 2011. PMID: 21470148 Review.
Host Carbon Dioxide Concentration Is an Independent Stress for Cryptococcus neoformans That Affects Virulence and Antifungal Susceptibility.
Krysan DJ, Zhai B, Beattie SR, Misel KM, Wellington M, Lin X. Krysan DJ, et al. Among authors: zhai b. mBio. 2019 Jul 2;10(4):e01410-19. doi: 10.1128/mBio.01410-19. mBio. 2019. PMID: 31266878 Free PMC article.
Development of protective inflammation and cell-mediated immunity against Cryptococcus neoformans after exposure to hyphal mutants.
Zhai B, Wozniak KL, Masso-Silva J, Upadhyay S, Hole C, Rivera A, Wormley FL Jr, Lin X. Zhai B, et al. mBio. 2015 Oct 6;6(5):e01433-15. doi: 10.1128/mBio.01433-15. mBio. 2015. PMID: 26443458 Free PMC article.
Evaluation of the anticryptococcal activity of the antibiotic polymyxin B in vitro and in vivo.
Zhai B, Lin X. Zhai B, et al. Int J Antimicrob Agents. 2013 Mar;41(3):250-4. doi: 10.1016/j.ijantimicag.2012.11.006. Epub 2013 Jan 10. Int J Antimicrob Agents. 2013. PMID: 23313397
Polymyxin B (PMB), a cationic lipid oligopeptide used to treat Gram-negative bacterial infections, was previously identified to possess broad-spectrum antifungal activity and to work synergistically with azole antifungals in vitro. ...
Polymyxin B (PMB), a cationic lipid oligopeptide used to treat Gram-negative bacterial infections, was previously identified to posse …
The antidepressant sertraline provides a promising therapeutic option for neurotropic cryptococcal infections.
Zhai B, Wu C, Wang L, Sachs MS, Lin X. Zhai B, et al. Antimicrob Agents Chemother. 2012 Jul;56(7):3758-66. doi: 10.1128/AAC.00212-12. Epub 2012 Apr 16. Antimicrob Agents Chemother. 2012. PMID: 22508310 Free PMC article.
Polymyxin B, in combination with fluconazole, exerts a potent fungicidal effect.
Zhai B, Zhou H, Yang L, Zhang J, Jung K, Giam CZ, Xiang X, Lin X. Zhai B, et al. J Antimicrob Chemother. 2010 May;65(5):931-8. doi: 10.1093/jac/dkq046. Epub 2010 Feb 18. J Antimicrob Chemother. 2010. PMID: 20167587 Free PMC article.
The toxicity of the drug combination of polymyxin B and fluconazole was compared with that of each drug alone in mammalian cell cultures. ...The drug combination displayed no additional toxicity compared with polymyxin B alone when tested in cell culture. CONCLUSION …
The toxicity of the drug combination of polymyxin B and fluconazole was compared with that of each drug alone in mammalian cell cultu …
Secondary antifungal prophylaxis in hematological malignancy patients with previous invasive fungal disease: a retrospective analysis.
Liu M, Li Y, Zhang Y, Zhao X, Zhai B, Zhang Q, Wang L, Zhao Y, Li H, Wang Q, Gao C, Huang W, Yu L. Liu M, et al. Among authors: zhai b. PLoS One. 2014 Dec 22;9(12):e115461. doi: 10.1371/journal.pone.0115461. eCollection 2014. PLoS One. 2014. PMID: 25531544 Free PMC article.
Congenic strains for genetic analysis of virulence traits in Cryptococcus gattii.
Zhu P, Zhai B, Lin X, Idnurm A. Zhu P, et al. Among authors: zhai b. Infect Immun. 2013 Jul;81(7):2616-25. doi: 10.1128/IAI.00018-13. Epub 2013 May 13. Infect Immun. 2013. PMID: 23670558 Free PMC article.
CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System.
Drummond RA, Collar AL, Swamydas M, Rodriguez CA, Lim JK, Mendez LM, Fink DL, Hsu AP, Zhai B, Karauzum H, Mikelis CM, Rose SR, Ferre EM, Yockey L, Lemberg K, Kuehn HS, Rosenzweig SD, Lin X, Chittiboina P, Datta SK, Belhorn TH, Weimer ET, Hernandez ML, Hohl TM, Kuhns DB, Lionakis MS. Drummond RA, et al. Among authors: zhai b. PLoS Pathog. 2015 Dec 17;11(12):e1005293. doi: 10.1371/journal.ppat.1005293. eCollection 2015 Dec. PLoS Pathog. 2015. PMID: 26679537 Free PMC article.
[Elderly chronic lymphocytic leukemia combined with invasive aspergillosis infection in one case].
Li BL, Li SX, Wang TM, Zhu HL, Wang HT, Li J, Liu Y, Zhai B. Li BL, et al. Among authors: zhai b. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015 Feb;23(1):99-105. doi: 10.7534/j.issn.1009-2137.2015.01.019. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015. PMID: 25687054 Chinese.
RESULTS: at onset of disease, the patient was diagnosed as B-CLL, Rai stage is II. He was treated with a course of RF(fludarabine 50 mg×5, rituximab 600 mg×5) chemotherapy, and achived complete remission (CR) lasting for five years, then the patient was treated with multip …
RESULTS: at onset of disease, the patient was diagnosed as B-CLL, Rai stage is II. He was treated with a course of RF(fludarabine 50 …
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