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42,081 results
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Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.
Zhang C, Browne A, Child D, Tanzi RE. Zhang C, et al. J Biol Chem. 2010 Sep 10;285(37):28472-80. doi: 10.1074/jbc.M110.133520. Epub 2010 Jul 9. J Biol Chem. 2010. PMID: 20622013 Free PMC article.
An emerging role for Ubiquilin 1 in regulating protein quality control system and in disease pathogenesis.
Zhang C, Saunders AJ. Zhang C, et al. Discov Med. 2009 Jun;8(40):18-22. Discov Med. 2009. PMID: 19772837 Free PMC article. Review.
Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein.
Zhang C, Browne A, Child D, Divito JR, Stevenson JA, Tanzi RE. Zhang C, et al. J Biol Chem. 2010 Mar 19;285(12):8515-26. doi: 10.1074/jbc.M109.079079. Epub 2010 Jan 22. J Biol Chem. 2010. PMID: 20097758 Free PMC article.
Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage.
Zhang C, Browne A, Kim DY, Tanzi RE. Zhang C, et al. Curr Alzheimer Res. 2010 Feb;7(1):21-6. doi: 10.2174/156720510790274428. Curr Alzheimer Res. 2010. PMID: 20205669 Free PMC article.
Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density.
Zhang C, Browne A, Divito JR, Stevenson JA, Romano D, Dong Y, Xie Z, Tanzi RE. Zhang C, et al. J Alzheimers Dis. 2010;22(2):683-984. doi: 10.3233/JAD-2010-100816. J Alzheimers Dis. 2010. PMID: 20847415 Free PMC article.
Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro.
Norstrom EM, Zhang C, Tanzi R, Sisodia SS. Norstrom EM, et al. Among authors: zhang c. J Neurosci. 2010 Nov 17;30(46):15677-85. doi: 10.1523/JNEUROSCI.4464-10.2010. J Neurosci. 2010. PMID: 21084623 Free PMC article.
Natural compounds that modulate BACE1-processing of amyloid-beta precursor protein in Alzheimer's disease.
Zhang C. Zhang C. Discov Med. 2012 Sep;14(76):189-97. Discov Med. 2012. PMID: 23021373 Review.
Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of β-amyloid by cells other than excitatory neurons.
Veeraraghavalu K, Zhang C, Zhang X, Tanzi RE, Sisodia SS. Veeraraghavalu K, et al. Among authors: zhang c, zhang x. J Neurosci. 2014 Mar 5;34(10):3668-73. doi: 10.1523/JNEUROSCI.5079-13.2014. J Neurosci. 2014. PMID: 24599465 Free PMC article.
A three-dimensional human neural cell culture model of Alzheimer's disease.
Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. Choi SH, et al. Among authors: zhang c. Nature. 2014 Nov 13;515(7526):274-8. doi: 10.1038/nature13800. Epub 2014 Oct 12. Nature. 2014. PMID: 25307057 Free PMC article.
Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments.
Wang H, Sang N, Zhang C, Raghupathi R, Tanzi RE, Saunders A. Wang H, et al. Among authors: zhang c. Biochemistry. 2015 May 12;54(18):2806-16. doi: 10.1021/acs.biochem.5b00329. Epub 2015 Apr 28. Biochemistry. 2015. PMID: 25910068 Free PMC article.
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