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Aurora-A - a guardian of poles.
Marumoto T, Zhang D, Saya H. Marumoto T, et al. Nat Rev Cancer. 2005 Jan;5(1):42-50. doi: 10.1038/nrc1526. Nat Rev Cancer. 2005. PMID: 15630414 Review.
Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models.
Zhang D, Hirota T, Marumoto T, Shimizu M, Kunitoku N, Sasayama T, Arima Y, Feng L, Suzuki M, Takeya M, Saya H. Zhang D, et al. Oncogene. 2004 Nov 18;23(54):8720-30. doi: 10.1038/sj.onc.1208153. Oncogene. 2004. PMID: 15480417
PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin.
Feng L, Yunoue S, Tokuo H, Ozawa T, Zhang D, Patrakitkomjorn S, Ichimura T, Saya H, Araki N. Feng L, et al. FEBS Lett. 2004 Jan 16;557(1-3):275-82. doi: 10.1016/s0014-5793(03)01507-2. FEBS Lett. 2004. PMID: 14741381
CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function.
Kunitoku N, Sasayama T, Marumoto T, Zhang D, Honda S, Kobayashi O, Hatakeyama K, Ushio Y, Saya H, Hirota T. Kunitoku N, et al. Dev Cell. 2003 Dec;5(6):853-64. doi: 10.1016/s1534-5807(03)00364-2. Dev Cell. 2003. PMID: 14667408
Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells.
Marumoto T, Hirota T, Morisaki T, Kunitoku N, Zhang D, Ichikawa Y, Sasayama T, Kuninaka S, Mimori T, Tamaki N, Kimura M, Okano Y, Saya H. Marumoto T, et al. Genes Cells. 2002 Nov;7(11):1173-82. doi: 10.1046/j.1365-2443.2002.00592.x. Genes Cells. 2002. PMID: 12390251
NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment.
Mori D, Yano Y, Toyo-oka K, Yoshida N, Yamada M, Muramatsu M, Zhang D, Saya H, Toyoshima YY, Kinoshita K, Wynshaw-Boris A, Hirotsune S. Mori D, et al. Mol Cell Biol. 2007 Jan;27(1):352-67. doi: 10.1128/MCB.00878-06. Epub 2006 Oct 23. Mol Cell Biol. 2007. PMID: 17060449 Free PMC article.
Chfr is required for tumor suppression and Aurora A regulation.
Yu X, Minter-Dykhouse K, Malureanu L, Zhao WM, Zhang D, Merkle CJ, Ward IM, Saya H, Fang G, van Deursen J, Chen J. Yu X, et al. Nat Genet. 2005 Apr;37(4):401-6. doi: 10.1038/ng1538. Epub 2005 Mar 27. Nat Genet. 2005. PMID: 15793587
Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1.
Sasayama T, Marumoto T, Kunitoku N, Zhang D, Tamaki N, Kohmura E, Saya H, Hirota T. Sasayama T, et al. Genes Cells. 2005 Jul;10(7):627-38. doi: 10.1111/j.1365-2443.2005.00870.x. Genes Cells. 2005. PMID: 15966895
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