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ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4PHAII mice.
Zhang C, Wang L, Su XT, Zhang J, Lin DH, Wang WH. Zhang C, et al. Among authors: zhang j. Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F682-F688. doi: 10.1152/ajprenal.00420.2016. Epub 2016 Nov 9. Am J Physiol Renal Physiol. 2017. PMID: 28365586 Free PMC article.
Potassium conservation is impaired in mice with reduced renal expression of Kir4.1.
Malik S, Lambert E, Zhang J, Wang T, Clark HL, Cypress M, Goldman BI, Porter GA Jr, Pena S, Nino W, Gray DA. Malik S, et al. Among authors: zhang j. Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1271-F1282. doi: 10.1152/ajprenal.00022.2018. Epub 2018 Aug 15. Am J Physiol Renal Physiol. 2018. PMID: 30110571 Free PMC article.
Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.
Castañeda-Bueno M, Arroyo JP, Zhang J, Puthumana J, Yarborough O 3rd, Shibata S, Rojas-Vega L, Gamba G, Rinehart J, Lifton RP. Castañeda-Bueno M, et al. Among authors: zhang j. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E879-E886. doi: 10.1073/pnas.1620315114. Epub 2017 Jan 17. Proc Natl Acad Sci U S A. 2017. PMID: 28096417 Free PMC article.
C-terminally truncated, kidney-specific variants of the WNK4 kinase lack several sites that regulate its activity.
Murillo-de-Ozores AR, Rodríguez-Gama A, Bazúa-Valenti S, Leyva-Ríos K, Vázquez N, Pacheco-Álvarez D, De La Rosa-Velázquez IA, Wengi A, Stone KL, Zhang J, Loffing J, Lifton RP, Yang CL, Ellison DH, Gamba G, Castañeda-Bueno M. Murillo-de-Ozores AR, et al. Among authors: zhang j. J Biol Chem. 2018 Aug 3;293(31):12209-12221. doi: 10.1074/jbc.RA118.003037. Epub 2018 Jun 19. J Biol Chem. 2018. PMID: 29921588 Free PMC article.
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