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The development of highly potent inhibitors for porcupine.
Wang X, Moon J, Dodge ME, Pan X, Zhang L, Hanson JM, Tuladhar R, Ma Z, Shi H, Williams NS, Amatruda JF, Carroll TJ, Lum L, Chen C. Wang X, et al. Among authors: zhang l. J Med Chem. 2013 Mar 28;56(6):2700-4. doi: 10.1021/jm400159c. Epub 2013 Mar 19. J Med Chem. 2013. PMID: 23477365 Free PMC article.
Development of a triazole class of highly potent Porcn inhibitors.
You L, Zhang C, Yarravarapu N, Morlock L, Wang X, Zhang L, Williams NS, Lum L, Chen C. You L, et al. Among authors: zhang l, zhang c. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895. doi: 10.1016/j.bmcl.2016.11.012. Epub 2016 Nov 11. Bioorg Med Chem Lett. 2016. PMID: 27876319 Free PMC article.
Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.
Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L. Moon J, et al. Among authors: zhang ls, zhang s. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1649-1654. doi: 10.1073/pnas.1621346114. Epub 2017 Jan 31. Proc Natl Acad Sci U S A. 2017. PMID: 28143939 Free PMC article.
Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.
Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L. Wu X, et al. Among authors: zhang ls, zhang x. Nat Cell Biol. 2017 Oct;19(10):1226-1236. doi: 10.1038/ncb3616. Epub 2017 Sep 25. Nat Cell Biol. 2017. PMID: 28945232 Free PMC article.
Chemical Modulation of WNT Signaling in Cancer.
Zhang LS, Lum L. Zhang LS, et al. Prog Mol Biol Transl Sci. 2018 Jan;153:245-269. doi: 10.1016/bs.pmbts.2017.11.008. Epub 2018 Jan 8. Prog Mol Biol Transl Sci. 2018. PMID: 29389519 Review.
Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9.
Zhang LS, Kang X, Lu J, Zhang Y, Wu X, Wu G, Zheng J, Tuladhar R, Shi H, Wang Q, Morlock L, Yao H, Huang LJ, Maire P, Kim J, Williams N, Xu J, Chen C, Zhang CC, Lum L. Zhang LS, et al. Among authors: zhang cc, zhang y. EBioMedicine. 2019 Jan;39:145-158. doi: 10.1016/j.ebiom.2018.11.039. Epub 2018 Dec 6. EBioMedicine. 2019. PMID: 30528456 Free PMC article.
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