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Discovery of EBI-907: A highly potent and orally active B-Raf(V600E) inhibitor for the treatment of melanoma and associated cancers.
Lu B, Cao H, Cao J, Huang S, Hu Q, Liu D, Shen R, Shen X, Tao W, Wan H, Wang D, Yan Y, Yang L, Zhang J, Zhang L, Zhang L, Zhang M. Lu B, et al. Among authors: zhang l, zhang m, zhang j. Bioorg Med Chem Lett. 2016 Feb 1;26(3):819-823. doi: 10.1016/j.bmcl.2015.12.086. Epub 2015 Dec 24. Bioorg Med Chem Lett. 2016. PMID: 26739779
Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.
Xu LL, Zhu JF, Xu XL, Zhu J, Li L, Xi MY, Jiang ZY, Zhang MY, Liu F, Lu MC, Bao QC, Li Q, Zhang C, Wei JL, Zhang XJ, Zhang LS, You QD, Sun HP. Xu LL, et al. Among authors: zhang ls, zhang c, zhang my, zhang xj. J Med Chem. 2015 Jul 23;58(14):5419-36. doi: 10.1021/acs.jmedchem.5b00170. Epub 2015 Jul 7. J Med Chem. 2015. PMID: 26111355
WITHDRAWN: Discovery of SHR1977: A highly potent and selective ROMK inhibitor.
Li X, Zhang Y, Chen Y, He W, Wan H, Zhang L, Hu Q, Feng J, Yuan J, Dong Q, Cao G, Zhang L, He F, Bai C, Tao W. Li X, et al. Among authors: zhang l, zhang y. Bioorg Med Chem Lett. 2016 Jun 27:S0960-894X(16)30683-7. doi: 10.1016/j.bmcl.2016.06.072. Online ahead of print. Bioorg Med Chem Lett. 2016. PMID: 27377326
Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.
Zhu Y, Li L, Zhang G, Wan H, Yang C, Diao X, Chen X, Zhang L, Zhong D. Zhu Y, et al. Among authors: zhang l, zhang g. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:117-127. doi: 10.1016/j.jchromb.2016.08.009. Epub 2016 Aug 7. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27541626 Clinical Trial.
Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin's Lymphoma.
Lu B, Shen X, Zhang L, Liu D, Zhang C, Cao J, Shen R, Zhang J, Wang D, Wan H, Xu Z, Ho MH, Zhang M, Zhang L, He F, Tao W. Lu B, et al. Among authors: zhang l, zhang m, zhang c, zhang j. ACS Med Chem Lett. 2018 Jan 29;9(2):98-102. doi: 10.1021/acsmedchemlett.7b00437. eCollection 2018 Feb 8. ACS Med Chem Lett. 2018. PMID: 29456795 Free PMC article.
123,615 results
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