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A VH1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite.
Kumar S, Ju B, Shapero B, Lin X, Ren L, Zhang L, Li D, Zhou Z, Feng Y, Sou C, Mann CJ, Hao Y, Sarkar A, Hou J, Nunnally C, Hong K, Wang S, Ge X, Su B, Landais E, Sok D, Zwick MB, He L, Zhu J, Wilson IA, Shao Y. Kumar S, et al. Among authors: zhang l. Sci Adv. 2020 Sep 16;6(38):eabb1328. doi: 10.1126/sciadv.abb1328. Print 2020 Sep. Sci Adv. 2020. PMID: 32938661 Free PMC article.
An MPER antibody neutralizes HIV-1 using germline features shared among donors.
Zhang L, Irimia A, He L, Landais E, Rantalainen K, Leaman DP, Vollbrecht T, Stano A, Sands DI, Kim AS; IAVI Protocol G Investigators; Poignard P, Burton DR, Murrell B, Ward AB, Zhu J, Wilson IA, Zwick MB. Zhang L, et al. Nat Commun. 2019 Nov 26;10(1):5389. doi: 10.1038/s41467-019-12973-1. Nat Commun. 2019. PMID: 31772165 Free PMC article.
HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies.
Rantalainen K, Berndsen ZT, Antanasijevic A, Schiffner T, Zhang X, Lee WH, Torres JL, Zhang L, Irimia A, Copps J, Zhou KH, Kwon YD, Law WH, Schramm CA, Verardi R, Krebs SJ, Kwong PD, Doria-Rose NA, Wilson IA, Zwick MB, Yates JR 3rd, Schief WR, Ward AB. Rantalainen K, et al. Among authors: zhang l, zhang x. Cell Rep. 2020 Apr 28;31(4):107583. doi: 10.1016/j.celrep.2020.107583. Cell Rep. 2020. PMID: 32348769 Free PMC article.
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