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Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation.
Zhang S, Liu H, Amarsingh GV, Cheung CC, Hogl S, Narayanan U, Zhang L, McHarg S, Xu J, Gong D, Kennedy J, Barry B, Choong YS, Phillips AR, Cooper GJ. Zhang S, et al. Among authors: zhang l. Cardiovasc Diabetol. 2014 Jun 14;13:100. doi: 10.1186/1475-2840-13-100. Cardiovasc Diabetol. 2014. PMID: 24927960 Free PMC article.
Diabetes-induced alterations in tissue collagen and carboxymethyllysine in rat kidneys: Association with increased collagen-degrading proteinases and amelioration by Cu(II)-selective chelation.
Brings S, Zhang S, Choong YS, Hogl S, Middleditch M, Kamalov M, Brimble MA, Gong D, Cooper GJ. Brings S, et al. Among authors: zhang s. Biochim Biophys Acta. 2015 Aug;1852(8):1610-8. doi: 10.1016/j.bbadis.2015.04.014. Epub 2015 Apr 18. Biochim Biophys Acta. 2015. PMID: 25900786 Free article.
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