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RB depletion is required for the continuous growth of tumors initiated by loss of RB.
Doan A, Arand J, Gong D, Drainas AP, Shue YT, Lee MC, Zhang S, Walter DM, Chaikovsky AC, Feldser DM, Vogel H, Dow LE, Skotheim JM, Sage J. Doan A, et al. Among authors: zhang s. PLoS Genet. 2021 Dec 8;17(12):e1009941. doi: 10.1371/journal.pgen.1009941. eCollection 2021 Dec. PLoS Genet. 2021. PMID: 34879057 Free PMC article.
Increasing cell size remodels the proteome and promotes senescence.
Lanz MC, Zatulovskiy E, Swaffer MP, Zhang L, Ilerten I, Zhang S, You DS, Marinov G, McAlpine P, Elias JE, Skotheim JM. Lanz MC, et al. Among authors: zhang l, zhang s. Mol Cell. 2022 Sep 1;82(17):3255-3269.e8. doi: 10.1016/j.molcel.2022.07.017. Epub 2022 Aug 19. Mol Cell. 2022. PMID: 35987199 Free PMC article.
Delineation of proteome changes driven by cell size and growth rate.
Zatulovskiy E, Lanz MC, Zhang S, McCarthy F, Elias JE, Skotheim JM. Zatulovskiy E, et al. Among authors: zhang s. Front Cell Dev Biol. 2022 Sep 5;10:980721. doi: 10.3389/fcell.2022.980721. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36133920 Free PMC article.
Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells.
Lanz MC, Zhang S, Swaffer MP, Hernández Götz L, McCarty F, Ziv I, Jarosz DF, Elias JE, Skotheim JM. Lanz MC, et al. Among authors: zhang s. bioRxiv [Preprint]. 2023 Oct 26:2023.10.16.562558. doi: 10.1101/2023.10.16.562558. bioRxiv. 2023. Update in: Nat Struct Mol Biol. 2024 Dec;31(12):1859-1871. doi: 10.1038/s41594-024-01353-z. PMID: 37905015 Free PMC article. Updated. Preprint.
Cell size modulates ferroptosis susceptibility.
Zatulovskiy E, Murray MB, Zhang S, Dixon SJ, Skotheim JM. Zatulovskiy E, et al. Among authors: zhang s. bioRxiv [Preprint]. 2026 Mar 11:2025.10.25.684524. doi: 10.1101/2025.10.25.684524. bioRxiv. 2026. PMID: 41279670 Free PMC article. Preprint.
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