Zhang W - Search Results

1

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.

Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D. Canny MD, et al. Among authors: zhang w. Nat Biotechnol. 2018 Jan;36(1):95-102. doi: 10.1038/nbt.4021. Epub 2017 Nov 27. Nat Biotechnol. 2018. PMID: 29176614 Free PMC article.

2

Drug development: Allosteric inhibitors hit USP7 hard.

Zhang W, Sidhu SS. Zhang W, et al. Nat Chem Biol. 2018 Jan 16;14(2):110-111. doi: 10.1038/nchembio.2557. Nat Chem Biol. 2018. PMID: 29337966 No abstract available.

3

De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks.

Zhang W, Durocher D. Zhang W, et al. Genes Dev. 2010 Mar 1;24(5):502-15. doi: 10.1101/gad.1869110. Genes Dev. 2010. PMID: 20194442 Free PMC article.

4

Engineering cell signaling modulators from native protein-protein interactions.

Zhang W, Ben-David M, Sidhu SS. Zhang W, et al. Curr Opin Struct Biol. 2017 Aug;45:25-35. doi: 10.1016/j.sbi.2016.11.002. Epub 2016 Nov 17. Curr Opin Struct Biol. 2017. PMID: 27866084 Review.

5

Generating Intracellular Modulators of E3 Ligases and Deubiquitinases from Phage-Displayed Ubiquitin Variant Libraries.

Zhang W, Sidhu SS. Zhang W, et al. Methods Mol Biol. 2018;1844:101-119. doi: 10.1007/978-1-4939-8706-1_8. Methods Mol Biol. 2018. PMID: 30242706

6

Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process.

Chung DK, Chan JN, Strecker J, Zhang W, Ebrahimi-Ardebili S, Lu T, Abraham KJ, Durocher D, Mekhail K. Chung DK, et al. Among authors: zhang w. Nat Commun. 2015 Jul 24;6:7742. doi: 10.1038/ncomms8742. Nat Commun. 2015. PMID: 26205667 Free article.

7

DNA damage signalling targets the kinetochore to promote chromatin mobility.

Strecker J, Gupta GD, Zhang W, Bashkurov M, Landry MC, Pelletier L, Durocher D. Strecker J, et al. Among authors: zhang w. Nat Cell Biol. 2016 Mar;18(3):281-90. doi: 10.1038/ncb3308. Epub 2016 Feb 1. Nat Cell Biol. 2016. PMID: 26829389

8

Dun1 counts on rad53 to be turned on.

Zhang W, Durocher D. Zhang W, et al. Mol Cell. 2008 Jul 11;31(1):1-2. doi: 10.1016/j.molcel.2008.06.009. Mol Cell. 2008. PMID: 18614039 Free article.

9

The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.

O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D. O'Donnell L, et al. Among authors: zhang w. Mol Cell. 2010 Nov 24;40(4):619-31. doi: 10.1016/j.molcel.2010.10.024. Epub 2010 Nov 4. Mol Cell. 2010. PMID: 21055983 Free PMC article.

10

A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.

Gabrielsen M, Buetow L, Nakasone MA, Ahmed SF, Sibbet GJ, Smith BO, Zhang W, Sidhu SS, Huang DT. Gabrielsen M, et al. Among authors: zhang w. Mol Cell. 2017 Oct 19;68(2):456-470.e10. doi: 10.1016/j.molcel.2017.09.027. Mol Cell. 2017. PMID: 29053960 Free PMC article.

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