Zhang X - Search Results

1

Biased multicomponent reactions to develop novel bromodomain inhibitors.

McKeown MR, Shaw DL, Fu H, Liu S, Xu X, Marineau JJ, Huang Y, Zhang X, Buckley DL, Kadam A, Zhang Z, Blacklow SC, Qi J, Zhang W, Bradner JE. McKeown MR, et al. Among authors: zhang w, zhang z, zhang x. J Med Chem. 2014 Nov 13;57(21):9019-27. doi: 10.1021/jm501120z. Epub 2014 Oct 31. J Med Chem. 2014. PMID: 25314271 Free PMC article.

2

HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib.

Yang G, Buhrlage SJ, Tan L, Liu X, Chen J, Xu L, Tsakmaklis N, Chen JG, Patterson CJ, Brown JR, Castillo JJ, Zhang W, Zhang X, Liu S, Cohen P, Hunter ZR, Gray N, Treon SP. Yang G, et al. Among authors: zhang w, zhang x. Blood. 2016 Jun 23;127(25):3237-52. doi: 10.1182/blood-2016-01-695098. Epub 2016 May 3. Blood. 2016. PMID: 27143257 Free article.

3

Organocatalytic One-Pot Asymmetric Synthesis of Thiolated Spiro-γ-lactam Oxindoles Bearing Three Stereocenters.

Huang X, Liu M, Pham K, Zhang X, Yi WB, Jasinski JP, Zhang W. Huang X, et al. Among authors: zhang w, zhang x. J Org Chem. 2016 Jul 1;81(13):5362-9. doi: 10.1021/acs.joc.6b00653. Epub 2016 Jun 14. J Org Chem. 2016. PMID: 27258150

4

Stereoselective synthesis of fused tetrahydroquinazolines through one-pot double [3 + 2] dipolar cycloadditions followed by [5 + 1] annulation.

Zhang X, Pham K, Liu S, Legris M, Muthengi A, Jasinski JP, Zhang W. Zhang X, et al. Among authors: zhang w. Beilstein J Org Chem. 2016 Oct 18;12:2204-2210. doi: 10.3762/bjoc.12.211. eCollection 2016. Beilstein J Org Chem. 2016. PMID: 27829928 Free PMC article.

5

A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association.

Huang H, Liu S, Jean M, Simpson S, Huang H, Merkley M, Hayashi T, Kong W, Rodríguez-Sánchez I, Zhang X, Yosief HO, Miao H, Que J, Kobie JJ, Bradner J, Santoso NG, Zhang W, Zhu J. Huang H, et al. Among authors: zhang w, zhang x. Front Microbiol. 2017 Jun 7;8:1035. doi: 10.3389/fmicb.2017.01035. eCollection 2017. Front Microbiol. 2017. PMID: 28638377 Free PMC article.

6

Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors.

Liu S, Yosief HO, Dai L, Huang H, Dhawan G, Zhang X, Muthengi AM, Roberts J, Buckley DL, Perry JA, Wu L, Bradner JE, Qi J, Zhang W. Liu S, et al. Among authors: zhang w, zhang x. J Med Chem. 2018 Sep 13;61(17):7785-7795. doi: 10.1021/acs.jmedchem.8b00765. Epub 2018 Aug 30. J Med Chem. 2018. PMID: 30125504 Free PMC article.

7

One-pot Fluorination and Organocatalytic Robinson Annulation for Asymmetric Synthesis of Mono- and Difluorinated Cyclohexenones.

Huang X, Zhao W, Zhang X, Liu M, Vasconcelos SNS, Zhang W. Huang X, et al. Among authors: zhang w, zhang x. Molecules. 2018 Sep 4;23(9):2251. doi: 10.3390/molecules23092251. Molecules. 2018. PMID: 30181479 Free PMC article.

8

One-Pot Double [3 + 2] Cycloadditions for Diastereoselective Synthesis of Pyrrolidine-Based Polycyclic Systems.

Zhang X, Qiu W, Ma X, Evans J, Kaur M, Jasinski JP, Zhang W. Zhang X, et al. Among authors: zhang w. J Org Chem. 2018 Nov 2;83(21):13536-13542. doi: 10.1021/acs.joc.8b02046. Epub 2018 Oct 18. J Org Chem. 2018. PMID: 30296831

9

One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions.

Ma X, Zhang X, Qiu W, Zhang W, Wan B, Evans J, Zhang W. Ma X, et al. Among authors: zhang w, zhang x. Molecules. 2019 Feb 8;24(3):601. doi: 10.3390/molecules24030601. Molecules. 2019. PMID: 30743991 Free PMC article.

10

Double 1,3-Dipolar Cycloadditions of Two Nonstabilized Azomethine Ylides for Polycyclic Pyrrolidines.

Zhang X, Qiu W, Evans J, Kaur M, Jasinski JP, Zhang W. Zhang X, et al. Among authors: zhang w. Org Lett. 2019 Apr 5;21(7):2176-2179. doi: 10.1021/acs.orglett.9b00487. Epub 2019 Mar 18. Org Lett. 2019. PMID: 30883128

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