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Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site.
Chen L, Wang ZG, Aleshin AE, Chen F, Chen J, Jiang F, Alitongbieke G, Zeng Z, Ma Y, Huang M, Zhou H, Cadwell G, Zheng JF, Huang PQ, Liddington RC, Zhang XK, Su Y. Chen L, et al. Among authors: zhang xk. Chem Biol. 2014 May 22;21(5):596-607. doi: 10.1016/j.chembiol.2014.02.017. Epub 2014 Apr 3. Chem Biol. 2014. PMID: 24704507 Free PMC article.
Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest.
Dawson MI, Harris DL, Liu G, Hobbs PD, Lange CW, Jong L, Bruey-Sedano N, James SY, Zhang XK, Peterson VJ, Leid M, Farhana L, Rishi AK, Fontana JA. Dawson MI, et al. Among authors: zhang xk. J Med Chem. 2004 Jul 1;47(14):3518-36. doi: 10.1021/jm030524k. J Med Chem. 2004. PMID: 15214780
Determinants of retinoid X receptor transcriptional antagonism.
Cavasotto CN, Liu G, James SY, Hobbs PD, Peterson VJ, Bhattacharya AA, Kolluri SK, Zhang XK, Leid M, Abagyan R, Liddington RC, Dawson MI. Cavasotto CN, et al. Among authors: zhang xk. J Med Chem. 2004 Aug 26;47(18):4360-72. doi: 10.1021/jm030651g. J Med Chem. 2004. PMID: 15317450
A structure-based approach to retinoid X receptor-alpha inhibition.
Stebbins JL, Jung D, Leone M, Zhang XK, Pellecchia M. Stebbins JL, et al. Among authors: zhang xk. J Biol Chem. 2006 Jun 16;281(24):16643-8. doi: 10.1074/jbc.M600318200. Epub 2006 Apr 10. J Biol Chem. 2006. PMID: 16606625 Free article.
An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.
Dawson MI, Xia Z, Liu G, Ye M, Fontana JA, Farhana L, Patel BB, Arumugarajah S, Bhuiyan M, Zhang XK, Han YH, Stallcup WB, Fukushi J, Mustelin T, Tautz L, Su Y, Harris DL, Waleh N, Hobbs PD, Jong L, Chao WR, Schiff LJ, Sani BP. Dawson MI, et al. Among authors: zhang xk. J Med Chem. 2007 May 31;50(11):2622-39. doi: 10.1021/jm0613323. Epub 2007 May 10. J Med Chem. 2007. PMID: 17489579 Free PMC article.
417 results