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The hERG potassium channel and hERG screening for drug-induced torsades de pointes.
Hancox JC, McPate MJ, El Harchi A, Zhang YH. Hancox JC, et al. Among authors: zhang yh. Pharmacol Ther. 2008 Aug;119(2):118-32. doi: 10.1016/j.pharmthera.2008.05.009. Epub 2008 Jun 18. Pharmacol Ther. 2008. PMID: 18616963 Review.
Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome.
El Harchi A, McPate MJ, Zhang Yh, Zhang H, Hancox JC. El Harchi A, et al. Among authors: zhang yh, zhang h. J Mol Cell Cardiol. 2009 Nov;47(5):743-7. doi: 10.1016/j.yjmcc.2009.02.027. Epub 2009 Mar 10. J Mol Cell Cardiol. 2009. PMID: 19285083 Free PMC article.
Acidosis impairs the protective role of hERG K(+) channels against premature stimulation.
Du CY, Adeniran I, Cheng H, Zhang YH, El Harchi A, McPate MJ, Zhang H, Orchard CH, Hancox JC. Du CY, et al. Among authors: zhang yh, zhang h. J Cardiovasc Electrophysiol. 2010 Oct;21(10):1160-9. doi: 10.1111/j.1540-8167.2010.01772.x. J Cardiovasc Electrophysiol. 2010. PMID: 20455975
Characterization of recombinant hERG K(+) channel inhibition by the active metabolite of amiodarone desethyl-amiodarone.
Zhang YH, Cheng H, Alexeenko VA, Dempsey CE, Hancox JC. Zhang YH, et al. J Electrocardiol. 2010 Sep-Oct;43(5):440-8. doi: 10.1016/j.jelectrocard.2010.04.007. Epub 2010 May 20. J Electrocardiol. 2010. PMID: 20493497
The hERG K(+) channel S4 domain L532P mutation: characterization at 37°C.
Zhang YH, Colenso CK, Sessions RB, Dempsey CE, Hancox JC. Zhang YH, et al. Biochim Biophys Acta. 2011 Oct;1808(10):2477-87. doi: 10.1016/j.bbamem.2011.07.001. Epub 2011 Jul 14. Biochim Biophys Acta. 2011. PMID: 21777565 Free PMC article.
High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943.
Cheng H, Zhang Y, Du C, Dempsey CE, Hancox JC. Cheng H, et al. Br J Pharmacol. 2012 Apr;165(7):2260-73. doi: 10.1111/j.1476-5381.2011.01688.x. Br J Pharmacol. 2012. PMID: 21950687 Free PMC article.
Molecular determinants of hERG potassium channel inhibition by disopyramide.
El Harchi A, Zhang YH, Hussein L, Dempsey CE, Hancox JC. El Harchi A, et al. Among authors: zhang yh. J Mol Cell Cardiol. 2012 Jan;52(1):185-95. doi: 10.1016/j.yjmcc.2011.09.021. Epub 2011 Sep 29. J Mol Cell Cardiol. 2012. PMID: 21989164
Action potential clamp and pharmacology of the variant 1 Short QT Syndrome T618I hERG K⁺ channel.
El Harchi A, Melgari D, Zhang YH, Zhang H, Hancox JC. El Harchi A, et al. Among authors: zhang yh, zhang h. PLoS One. 2012;7(12):e52451. doi: 10.1371/journal.pone.0052451. Epub 2012 Dec 26. PLoS One. 2012. PMID: 23300672 Free PMC article.
Interactions between voltage sensor and pore domains in a hERG K+ channel model from molecular simulations and the effects of a voltage sensor mutation.
Colenso CK, Sessions RB, Zhang YH, Hancox JC, Dempsey CE. Colenso CK, et al. Among authors: zhang yh. J Chem Inf Model. 2013 Jun 24;53(6):1358-70. doi: 10.1021/ci4000739. Epub 2013 May 24. J Chem Inf Model. 2013. PMID: 23672495
Ranolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants.
Du C, Zhang Y, El Harchi A, Dempsey CE, Hancox JC. Du C, et al. J Mol Cell Cardiol. 2014 Sep;74(100):220-30. doi: 10.1016/j.yjmcc.2014.05.013. Epub 2014 May 27. J Mol Cell Cardiol. 2014. PMID: 24877995 Free PMC article.
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